Hepatic encephalopathy

This study tests a refined procedure for people who develop severe, recurring hepatic encephalopathy after a TIPS procedure, a shunt placed to relieve pressure in the liver. The technique uses a coil and a smaller covered stent to narrow the shunt and reduce blood flow, aiming to…

This study looks at whether adding L-carnitine, a natural substance, to standard care can improve outcomes for critically ill adults with liver disease in the ICU. About 58 participants with conditions like liver failure or severe infections will be enrolled. Researchers will tra…

This study tests whether fecal microbiota transplantation (FMT) — transferring stool from healthy donors into the gut — can help prevent repeated episodes of hepatic encephalopathy (a serious brain condition) in people who have had TIPS surgery for liver problems. The trial enrol…

This study tests whether adding the blood thinner apixaban to the heart drug carvedilol can prevent complications like bleeding, fluid buildup, and confusion in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will take either api…

This study tests whether taking a protein supplement (Ensure Enlive) in the late evening and early morning can reduce hospital readmissions for people with hepatic encephalopathy, a brain condition caused by liver disease. The trial enrolls 40 adults with cirrhosis who have been …

This pilot study tests whether taking melatonin at night can increase REM sleep and improve cognitive function in people with cirrhosis who have a complication called hepatic encephalopathy (HE). Participants take melatonin for one month and a control supplement (thiamine) for an…

This study is creating and testing a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness or trouble focusing, which are often missed. About 230 participants will fill out the questionnaire and t…

This pilot study at Mayo Clinic is testing whether a dietary supplement called resistant potato starch can change gut bacteria in people with cirrhosis who have had episodes of confusion (hepatic encephalopathy). Eleven participants will take 20 grams of potato starch twice daily…

This study follows 10,000 people with advanced chronic liver disease at Vienna General Hospital. Researchers will track their health over time, collect blood, urine, and tissue samples, and record complications like bleeding or liver failure. The goal is to better understand how …