HEPATIC ENCEPHALOPATHY

This study tests whether adding a blood thinner (apixaban) to a standard heart drug (carvedilol) can prevent serious complications like internal bleeding, fluid buildup, and liver failure in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable …

This study tests whether taking a protein supplement (Ensure Enlive) in the late evening and early morning can reduce hospital readmissions for people with hepatic encephalopathy, a brain condition caused by severe liver disease. About 40 adults with cirrhosis who have been hospi…

This study tests whether two drugs that calm the immune system—high-dose steroids or a medicine called anti-thymocyte globulin—can help children with sudden, severe liver failure survive without needing a liver transplant. About 163 children aged 1 to 17 will be randomly assigned…

This study tests whether weekly infusions of albumin (a protein) can improve thinking and quality of life in people with cirrhosis who have had episodes of hepatic encephalopathy (brain fog). Thirty participants will receive both saline (placebo) and albumin infusions over 8 week…

This study looks at whether a special potato starch supplement can change gut bacteria in people with cirrhosis who have had episodes of confusion (hepatic encephalopathy). Eleven participants will take the starch for 4 weeks, and researchers will measure changes in stool and thi…

This study follows 10,000 people with advanced chronic liver disease to see how their condition changes over time. Researchers collect medical data and samples like blood, urine, and tissue to better understand cirrhosis and its complications. The goal is to learn more about the …

This study aims to create and test a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness and trouble focusing, which are often missed in regular checkups. About 230 participants will fill out th…