Hepatic encephalopathy

Researchers test whether fecal microbiota transplantation delivered by oral capsules can help cirrhosis patients whose hepatic encephalopathy no longer responds to standard lactulose and rifaximin. The trial enrolls 33 adults with cirrhosis and persistent or recurrent hepatic enc…

This study tested whether nifuroxazide, a drug used for gut infections, can help treat hepatic encephalopathy—a condition where liver disease causes confusion and brain fog. Researchers gave the drug to 80 hospitalized patients with moderate to severe symptoms. The goal was to se…

Researchers are testing whether stopping proton pump inhibitors (PPIs) after a transjugular intrahepatic portosystemic shunt (TIPS) procedure can lower the risk of hepatic encephalopathy, a brain condition linked to liver disease. Adults already taking PPIs and scheduled for TIPS…

This clinical trial investigates whether two existing medications, allopurinol and atorvastatin, can help prevent serious complications in people with stable liver cirrhosis. The study will compare these drugs against a placebo to see if they reduce the number of acute decompensa…

This study tested a sleep medication called lemborexant in 82 adults with liver cirrhosis who had trouble sleeping. The drug works by blocking wakefulness signals in the brain. Researchers measured sleep quality and checked for side effects on the liver. The goal was to see if le…

This study looked at whether speech features—like how people sound and what they say—can help detect or predict confusion caused by liver disease (hepatic encephalopathy). Researchers recorded speech tasks from 251 participants with cirrhosis and tracked their thinking skills and…