ACUTE RESPIRATORY DISTRESS SYNDROME

This study tests whether injecting stem cells from donated umbilical cords is safe for people with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 36 adults who haven't improved with standard care will receive the stem cells. The mai…

This study compares two ways of positioning patients with severe lung failure (ARDS) who are on a breathing machine: lying face-down for more than 48 hours straight versus 16-24 hours daily. The goal is to see which approach reduces deaths and causes fewer complications. About 78…

This study tests an investigational drug called AV-001 in people hospitalized with pneumonia caused by COVID-19 or other respiratory infections. The goal is to see if AV-001 is safe and helps patients recover faster when added to standard care. About 120 participants will receive…

This study looks at whether keeping patients with severe lung failure (ARDS) lying on their stomach for 40 hours at a time, instead of the usual 16 hours, can lower the chance of death. About 800 adults on breathing machines will be randomly assigned to one of the two positions. …

This study compares standard mechanical ventilation to a personalized, lung-stress oriented strategy in 1,100 adults with acute respiratory distress syndrome (ARDS). The goal is to see if tailoring the breathing machine settings to each patient can improve survival. Participants …

This study tests an experimental drug called paridiprubart in adults hospitalized with moderate-to-severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival…

This study tests whether adding umbilical cord stem cells (and their secretions) to standard care can help people with severe lung injury from pneumonia-related sepsis recover faster and lower the risk of death. About 15 adults aged 40 and older with severe ARDS will be randomly …

This study tests whether a drug called bevacizumab can help adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 200 participants will receive either the drug or a placebo, and researchers will track survival rates and oxygen levels.…

This study tests several experimental treatments for adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 600 participants will receive either an active drug or a placebo to see if the treatments improve survival and are safe. The ma…

This study compares two types of breathing support (high-frequency oscillation vs. conventional ventilation) in very premature infants with acute respiratory distress syndrome. The goal is to see which method better reduces the risk of chronic lung disease (bronchopulmonary dyspl…

This study tests a new approach for people with severe lung failure (ARDS) who are on a life-support machine called ECMO. Instead of giving small breaths, doctors will temporarily stop all breathing support to let the lungs rest completely. The goal is to see if this reduces lung…

This study tests a device called PrismaLung+ that removes carbon dioxide from the blood of critically ill patients who are on breathing machines. The goal is to see if adding this device to standard care helps improve blood gas levels and reduce complications. About 99 adults wit…

This Phase 3 trial tests whether a treatment called ExoFlo, made from stem cell particles, can help hospitalized adults with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), a serious lung condition. About 970 participants will receive either ExoFlo or a placebo thr…

This study tests whether adding a new drug (recombinant human plasma gelsolin) to standard care can help people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive either the drug o…

This study tests a drug called vilobelimab in adults hospitalized with severe lung failure (ARDS). About 200 participants will receive either the drug or a placebo. The main goal is to see if the drug reduces deaths within 28 days.

This study looks at whether sitting ARDS patients upright in bed can improve their breathing while on a ventilator. Researchers will compare upright positioning to standard care in 40 adults. The goal is to see if this simple change can make a difference in how well the lungs wor…

This study looks at whether safely sitting up patients with severe lung injury (ARDS) can improve oxygen levels as well as the standard face-down position does. Researchers will test this in 32 adults who are already on a breathing machine. The goal is to see if the sitting-up me…

This study looks at whether a simple blood test can help predict if a person with Acute Respiratory Distress Syndrome (ARDS) will develop a dangerous blood clot in the lungs (pulmonary embolism). Researchers will measure certain markers in the blood of 170 adults in the intensive…

This study looks at how a specific part of the breathing cycle (the time it takes for the lungs to empty) affects how air and blood flow are matched in the lungs of patients with ARDS. Researchers will use a special imaging technique (EIT) to measure these changes in 60 adults on…

This study watches 1,000 adults in intensive care with severe lung failure (ARDS) who are placed face down to help them breathe. Researchers want to learn who benefits most, whether it is safe for patients with brain injuries, and when to stop. The goal is to create better guidel…

This study follows 100 adults who needed a machine called ECMO to support their heart and lungs after a severe failure. Researchers want to understand how muscle wasting and weakness affect patients' recovery and quality of life. The goal is to find better ways to help people reg…

This study looks at how certain white blood cells (macrophages) in the lungs react to inflammation in people with Acute Respiratory Distress Syndrome (ARDS). Researchers will collect lung fluid, blood, and nose samples from 56 ICU patients on breathing machines. The goal is to un…

This study looks at a phenomenon called 'avalanche' in the lungs of people with acute respiratory distress syndrome (ARDS) who are on breathing machines. Researchers want to see how small airways open unevenly during inflation, which might cause lung damage. By studying 50 adults…

This study watches how the heart changes in adults with severe lung injury (ARDS) who need a breathing machine. Doctors will use heart ultrasounds and track medications to see how often right heart failure occurs and how it evolves. The goal is to learn more, not to test a new tr…

This study looks at 500 adults with a severe lung condition called ARDS to see if they can be grouped into two types based on inflammation. The goal is to find out if knowing a patient's subtype helps doctors choose better treatments, like fluids or steroids. This research does n…

This study involves 20 adults with severe lung failure (ARDS) who are on a breathing machine. Researchers will use a non-invasive imaging method called electrical impedance tomography (EIT) to see how the lungs respond to different ventilator pressure settings, both when lying on…

This study follows 550 children who needed a machine called ECMO to breathe after a sudden lung failure. Researchers want to learn how these children recover over the next year, including their thinking, movement, and quality of life. They will also compare two different ways of …

This study looks at 30 adults recovering from acute respiratory distress syndrome (ARDS) who are on a breathing machine. Researchers want to see if increasing the pressure in the lungs (called PEEP) can reduce the effort needed to breathe, which may prevent further lung damage. T…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…