ACUTE RESPIRATORY DISTRESS SYNDROME

This study looked at whether using sevoflurane gas for sedation, instead of the usual propofol, could help people with severe lung injury (ARDS) survive and spend less time on a breathing machine. About 700 adults in the hospital took part. The goal was to see if the gas sedation…

This study tested whether using a special antiseptic dressing (with chlorhexidine) on the tubes that connect patients to an ECMO machine can reduce serious infections. ECMO is a life-support machine for people with severe heart or lung failure. The trial involved 270 patients and…

This small pilot study tested a non-invasive device that stimulates the vagus nerve (a key nerve in the neck) in people hospitalized with mild-to-moderate traumatic brain injury. The goal was to see if adding this stimulation to standard care could reduce severe breathing problem…

This study tested whether a breathing machine strategy guided by lung pressure could better protect the heart in patients with acute respiratory distress syndrome (ARDS). Forty adults on ventilators were included. The approach aimed to reduce strain on the right side of the heart…

This study tested whether having COVID-19 patients with serious breathing problems lie face down (prone position) while using a high-flow oxygen mask could reduce the need for breathing tubes and lower death risk. About 405 adults with COVID-19 pneumonia and low oxygen levels too…

This study tested a drug called sivelestat sodium in 324 adults with acute respiratory distress syndrome (ARDS) and systemic inflammation. The drug works by blocking a harmful enzyme that damages lung tissue. Researchers measured whether it improved oxygen levels and reduced time…

This study tested if placing patients with severe acute respiratory distress syndrome (ARDS) on their stomachs (prone position) for at least 16 hours a day could lower the chance of dying. 474 adults on breathing machines were randomly assigned to lie face down or stay on their b…

This study tested a one-time infusion of stem cells (mesenchymal stromal cells) in 20 adults with severe lung failure caused by COVID-19. The goal was to see if the treatment improved oxygen levels within a week compared to a placebo. The trial is complete, but results are not ye…

This study tested a new way of using breathing machines for COVID-19 patients with severe lung injury. The goal was to see if using very small breaths (ultraprotective ventilation) could reduce lung damage and improve survival compared to standard care. About 220 adults on ventil…

This study looked at whether giving a gas called sevoflurane (used for sleep during surgery) for 48 hours can improve oxygen levels and reduce inflammation in people with acute respiratory distress syndrome (ARDS), a severe lung condition. Fifty adults with moderate to severe ARD…

This study tested if lying face down (prone positioning) helps hospitalized COVID-19 patients with low oxygen levels who are not candidates for breathing machines. About 600 adults took part. The goal was to see if this simple position change reduces deaths or the need for hospic…

This study looked at 10 adults with moderate-to-severe acute respiratory distress syndrome (ARDS) who were on breathing machines. Researchers used a non-invasive imaging technique called electrical impedance tomography (EIT) to find the best ventilator pressure settings that mini…

This study looked at 94 adults with severe lung failure (ARDS) who needed a breathing tube and were placed on their stomachs (prone position) to help them breathe. Researchers used a special imaging technique called electrical impedance tomography (EIT) to see how air and blood f…

This study tested a simple technique—pressing on the front of the chest—in 20 adults with severe lung injury (ARDS). The goal was to see if this pressure could improve how air and blood mix in the lungs and help the heart pump more effectively. Researchers used special imaging to…

This study tested whether a miniaturized ultrasound probe placed in the esophagus could help predict outcomes in 50 patients with severe lung failure (ARDS). The researchers measured how much the main vein collapses during breathing, which may indicate heart strain. The goal was …

This study examined 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers looked at immune cells and virus levels in fluid from the lungs to understand why some people get so sick. The goal was to find better ways to treat severe flu and prevent lu…

This study looked at 11 adults with acute respiratory distress syndrome (ARDS) to see if their body position (lying flat at 0° or slightly raised at 30°) changes the esophageal pressure reading used to set ventilators. Researchers measured pressure at both angles to find out if p…

This study looked at 60 adults with severe lung injury (ARDS) on breathing machines. It compared two ventilation methods—APRV and low tidal volume—to see which one better protects the right side of the heart from failing. The goal was to find out if one method is safer for the he…

This study looked at 25 adults in the intensive care unit with moderate to severe acute respiratory distress syndrome (ARDS). Researchers tested a new, simple way to measure if the small airways in the lungs close during normal breathing. The goal was to better understand how the…

This study looked at ways to improve the care, daily routines, and sleep of children in the pediatric intensive care unit (PICU). Researchers observed 56 children with acute respiratory distress syndrome to see how changes in light, sound, and daily activities could support their…

This study looked at 32 adults with severe lung failure (ARDS) who were on breathing machines. Researchers measured pressure inside the lungs when patients were lying on their back and then on their stomach (prone position). The goal was to see if stomach-lying changes lung press…

This study looked at how the pressure used to inflate the lungs during mechanical ventilation affects the right side of the heart in people with Acute Respiratory Distress Syndrome (ARDS). Researchers measured lung pressure and heart function in 50 adults and children. The goal w…

This study observed over 4,000 ICU patients in China who needed breathing support for acute respiratory failure. Researchers collected data on treatments, outcomes, and costs to better understand the disease burden. The goal was to gather current information, not to test a new tr…

This study looked at whether an AI system could help doctors make better decisions about ventilator settings for children (ages 1 month to 18 years) in the pediatric intensive care unit (PICU). The goal was to see if AI-guided care could increase the number of days children spend…

This study followed 38 children who survived acute respiratory distress syndrome (ARDS) to see how their lungs were doing one year later. Researchers measured lung stiffness, breathing symptoms like cough and wheeze, and looked at CT scans for any lasting damage. The goal was to …

This study involved 513 children with a severe lung condition called ARDS who were on breathing machines. Researchers took blood samples to look for different patterns of illness, called subtypes, that might need different treatments. The goal was not to test a new drug, but to b…

This study looked at stored blood samples from about 300 adults hospitalized with COVID-19 to see if a protein called suPAR could predict who would develop severe breathing failure needing a ventilator. Researchers measured suPAR levels and checked medical records for outcomes. T…

This study looked at how COVID-19 causes organ failure in intensive care patients. Researchers tracked 380 adults with suspected or confirmed COVID-19 in the ICU, measuring kidney injury, breathing problems, and survival rates. The goal was to better understand the disease, not t…