SEPTIC SHOCK

This study compares two intravenous fluids—sodium lactate and saline—in adults with septic shock. The goal is to see which one better supports heart function and helps maintain healthy acid levels in the blood. About 40 participants will receive one of the fluids in a blinded man…

This study looks at whether giving hydrocortisone (a steroid) to children with septic shock can prevent new or worsening organ failure and improve survival and quality of life. About 500 children in intensive care will receive either hydrocortisone or a placebo, and researchers w…

This study compares two medicines, adrenaline and dopamine, to see which works better for children with a severe type of septic shock that doesn't improve with fluids. About 90 children aged 1 month to 12 years will take part. Doctors will check things like blood pressure, heart …

This study looks at whether a machine called ECMO can help children with severe septic shock who are not getting better with standard care. ECMO acts like an artificial heart and lungs to support the body. The study will include 60 children and track how many survive after leavin…

This study tests whether using a bedside heart ultrasound (POCUS) to guide fluid and medication decisions improves outcomes for 140 adults with liver cirrhosis and severe sepsis or septic shock, compared to standard guideline-based care. The goal is to give just enough fluids to …

This study tests if a medicine called methylene blue can improve blood flow in patients with septic shock, a severe infection that causes dangerously low blood pressure. The trial will include 50 adults who are not getting better with standard fluids and medications. The main goa…

This study looks at whether a special filter called oXiris helps people with septic shock and acute kidney injury who need blood filtering. The filter aims to remove harmful toxins and calm inflammation. Researchers will compare survival and recovery in 360 adults who received ei…

This early study tests whether draining lymph fluid from a chest tube can lower harmful inflammation in people with septic shock. Ten adults in the surgical ICU will receive the drainage for up to 7 days. The goal is to see if the procedure is safe and can reduce inflammatory pro…

This study tests whether giving a blood-pressure-raising drug (norepinephrine) early and adjusting the dose quickly can help adults with septic shock survive longer. Researchers will compare this approach to standard care in 600 patients. The goal is to see if early treatment red…

This study tests a new, non-invasive treatment for septic shock, a life-threatening condition where the body's response to infection causes dangerous inflammation. The treatment uses focused ultrasound waves to stimulate the spleen, which may help reduce levels of inflammatory ch…

This pilot study tests whether giving angiotensin II early in the emergency department can help stabilize blood pressure in adults with septic shock. Twenty participants who need a standard blood pressure medication will receive angiotensin II through a vein. The main goal is to …

This study compares a strategy that limits non-resuscitation fluids to usual care in adults with septic shock. The goal is to see if a restrictive approach reduces death and serious complications. About 1,850 participants will be enrolled in ICUs across multiple centers.

This study compares two ways of using blood pressure medicines in people with septic shock, a severe infection that causes dangerously low blood pressure. About 2,800 ICU patients will either get vasopressin early or only as a rescue add-on to standard norepinephrine. The goal is…

This study looks at 300 adults with septic shock in the ICU. It uses a computer tool to randomly assign patients to get vasopressin either early or later, based on their norepinephrine dose. The goal is to see if the timing affects how much norepinephrine they need and if the too…

This study follows 200 adults with sepsis or septic shock who are receiving ARTICE® therapy in the ICU. Researchers will track changes in organ function, lab results, and recovery times to better understand how well the treatment works and who benefits most. The goal is to improv…

This study tests whether a program that includes guidelines, feedback, and education can help doctors use less vancomycin (a strong antibiotic) in children with suspected sepsis in intensive care units. The goal is to reduce side effects like kidney damage while still treating in…

This study tests whether giving two steroids (hydrocortisone and fludrocortisone) together can lower the risk of death in adults with septic shock, a life-threatening condition. About 336 patients will be randomly assigned to receive the combo or standard care. The main goal is t…

This study tests whether a personalized treatment with Pentaglobin (a mix of antibodies) can improve recovery in people with severe abdominal infection (peritonitis) that has led to sepsis or septic shock. About 200 adults will receive either standard care or standard care plus P…

This study looks at 240 adults in septic shock who develop a new irregular heartbeat. It compares three approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors without antiarrhythmi…

This study looks at whether a protein called vasorin can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Researchers will measure vasorin levels in 144 intensive care patients and compare the…

This study tests whether using a device that measures blood flow to the skin (called the peripheral perfusion index) can help doctors give fluids more precisely to elderly ICU patients with sepsis or shock. The goal is to prevent acute skin failure, a serious condition where the …

This study compares a combination of two sedatives (propofol and ketamine) against propofol alone in elderly ICU patients who need a breathing tube. The goal is to see if the combo reduces dangerous drops in blood pressure. About 41 patients aged 65 and older with heart disease a…

This study looks at whether a computer program can analyze data already collected in hospitals to help diagnose sepsis and septic shock more quickly. Researchers will study the records of 10,000 ICU patients to see if the program can speed up diagnosis and improve outcomes. The g…

This study looks at whether a new blood gas measurement (PvCO2-PaCO2/CaO2-CvO2 ratio) can help predict survival in people with septic shock. Researchers will compare this ratio to the standard lactate test in 30 adults. The goal is to find a more accurate way to assess patient ri…

This study observes 120 adults with septic shock in the ICU to see how their metabolism changes after a fluid challenge. Researchers measure oxygen use and organ function over several days. The goal is to better understand which patients benefit from fluids, not to test a new tre…

This study tests whether a gentle electrical stimulation of a nerve in the ear can reduce inflammation and improve heart rate balance in people with septic shock, a life-threatening condition. 34 participants will receive either active or sham stimulation alongside standard care.…

This study looks at how giving vasopressin early to adults with septic shock in the ICU might affect survival and kidney health. Researchers will track 1,200 patients who receive vasopressin along with standard treatment. The goal is to see if starting it sooner improves outcomes…

This study aims to see if a new scoring tool called SOFA-2 can better predict which ICU patients are at risk of dying within 30 days compared to the current standard. Researchers will also measure how common sepsis is in Turkish intensive care units. About 2,500 adult ICU patient…

This study looks at patients with a severe condition called mixed cardiogenic-vasoplegic shock, where the heart fails to pump and blood vessels widen too much. Researchers will review medical records from 2,500 adults in French hospitals to learn more about who survives and why. …

This study is observing 183 adults in the ICU with sepsis or septic shock to see if their cortisol levels can predict who is at higher risk of dying. Researchers will measure cortisol and track deaths in the ICU, at 28 days, and at 90 days. No treatments are given—the goal is to …

This study looks at whether adding specific nutrients to cells from septic shock patients can improve how their mitochondria (the cell's power plants) work. Septic shock is a severe infection that causes organ failure and has a high death rate. Researchers will take blood samples…

This study looks at how much antibiotic is removed when ICU patients with septic shock and kidney failure receive blood-cleaning treatments. Twenty adults will have their antibiotic levels measured before and after the blood passes through the cleaning cartridges. The goal is to …

This study looks at how well two different software programs measure heart function in people with septic shock, a life-threatening infection. Researchers will compare measurements from 60 adult patients to see if the software gives consistent results. The goal is to improve how …

This study aims to find biological markers that can predict whether a patient with sepsis will develop a more severe form called septic shock. Researchers will compare epigenetic markers in the blood of 25 male patients aged 45-75 who have sepsis after major digestive cancer surg…

This study looks at whether being frail before getting sick affects the chance of dying for adults aged 18 to 65 who are in the intensive care unit (ICU) with a severe infection called septic shock. Researchers will measure frailty using a simple scale and track survival for up t…

This study looks at 60 people with septic shock (a severe infection causing very low blood pressure) to see which method better predicts how much fluid they need: a heart monitor called cardiometry or an ultrasound check of a large vein. The goal is to help doctors give the right…

This study compares two ultrasound techniques—heart ultrasound and carotid artery ultrasound—to see which better predicts whether a septic shock patient will benefit from additional fluids. About 40 adults with septic shock will be enrolled. The goal is to improve how doctors dec…

This study looks at the best way to stop vasopressin, a drug used to raise blood pressure in people with septic shock. Researchers will compare slowly reducing the dose versus stopping it all at once. The goal is to see which method causes fewer dangerous drops in blood pressure.…

This study compares two methods for guiding early treatment of septic shock: the standard approach using lactate levels versus a newer method using the CO2 gap, which measures carbon dioxide in the blood. Researchers want to see if the CO2 gap method can better identify when tiss…

This study looks at how long the Oxiris hemofilter can effectively remove harmful toxins from the blood in adults with septic shock in the ICU. Researchers will take blood samples before and after the filter to measure its cleaning power over 24 hours. The goal is to find the bes…

This study observes about 1,950 emergency patients with suspected sepsis to see how well certain blood markers (like calprotectin) and rapid DNA tests can detect infections. The goal is to improve diagnosis and tailor treatment to each patient. Participants are adults admitted to…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…

This study is looking for new ways to quickly diagnose sepsis, a life-threatening reaction to infection, in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve early …