SEPTIC SHOCK

This early-stage study tested whether a procedure called therapeutic plasma exchange (TPE) is safe for adults with septic shock, a life-threatening infection that causes organ failure. Seventeen patients received TPE within 24 hours of diagnosis, where their blood plasma was remo…

This study tested whether giving very high doses of vitamin C to people with sepsis (a severe infection that can cause organ failure) could lower the chance of dying within 28 days. Over 200 adults in intensive care were randomly given either vitamin C or a placebo for up to 4 da…

This pilot study tested whether adding methylene blue to usual care is feasible for adults in the ICU with septic shock. The trial enrolled 50 patients and measured recruitment, consent, and treatment adherence. It was designed to see if a larger trial is possible, not to prove t…

This study tested a structured plan to manage fluids in patients with septic shock, a life-threatening condition. The goal was to see if actively removing excess fluid early could reduce fluid buildup and improve outcomes. 170 ICU patients were randomly assigned to either the new…

This study tested two ways to guide fluid treatment in 60 emergency department patients with septic shock: critical care ultrasound and noninvasive cardiac output monitoring. Both groups also received standard sepsis care. The goal was to see which method helps doctors give the r…

This study tested a technique called remote ischemic conditioning in 180 adults with septic shock. The treatment involves briefly inflating a blood pressure cuff on the arm to protect organs from damage. The goal was to see if this simple, non-drug approach could limit the severi…

This study looked at 400 critically ill patients with septic shock and acute kidney injury who needed dialysis. Researchers compared those who used a special filter called Oxiris, which removes toxins and inflammation, to those who used standard filters. The goal was to see if th…

This study tested whether a special donor plasma product (OctaplasLG) can help treat blood clotting problems in people with septic shock. The trial included 60 adults with septic shock and clotting issues. Researchers measured how quickly treatment was given and looked at surviva…

This study tested whether a personalized approach to giving fluids, using small 'mini-fluid challenges' to guide decisions, could reduce organ failure in people with septic shock. Over 500 ICU patients took part. The goal was to avoid both too little and too much fluid, which can…

This study tested whether a drug called GM-CSF can reduce new infections in ICU patients whose immune system is weakened after severe sepsis or septic shock. 166 adults were randomly given either GM-CSF or a placebo. The goal was to see if the drug could lower the number of hospi…

This study tested whether giving a concentrated protein solution (albumin) along with standard fluids is possible in patients with septic shock. 47 adults with severe infection and low blood pressure were enrolled. The main goal was to see if enough people could be recruited to r…

This pilot study tested whether giving a sodium lactate solution to people with septic shock could help manage their fluid balance. Septic shock is a life-threatening condition where blood pressure drops dangerously due to infection. The study involved 59 participants and compare…

This study tested whether adding a medication called methylene blue to standard care helps adults with septic shock recover faster. Researchers randomly assigned 88 patients to receive either methylene blue or a placebo to see if it could reverse shock and improve survival. The m…

This study tested whether a gentle massage technique called manual lymphatic drainage is safe and practical for patients recovering from septic shock. The goal was to see if it could help improve organ function and reduce complications. The trial involved 24 adults in the intensi…

This study looked at 60 adults with septic shock in the ICU to see how often bacteria leak from the gut into the blood. Researchers measured specific markers in blood samples taken over the first week. The goal was to understand this process better, not to test a new treatment.

This study looked at how the immune system becomes weakened after severe infections, injuries, burns, or major surgeries. Researchers measured immune function in 552 adults to understand when and why patients become more vulnerable to new infections. The goal is to develop better…

This study looked at 30 intensive care patients with septic shock to see how a drug called norepinephrine affects both large and tiny blood vessels. Doctors already use a measure called ScvO2 to check large blood vessels, but they wanted to see if a new tool measuring tissue oxyg…

This study examined whether the initial diagnosis given to patients when they enter the ICU can help predict their risk of dying. Researchers reviewed records of over 1,200 adults admitted to a mixed ICU in 2025. They focused on common critical conditions like sepsis, ARDS, and o…

This study looked at 145 people with septic shock to see if the timing of checking fluid effectiveness changes results. Patients received 500 ml of fluid over 10 minutes, and doctors checked if they responded right away and again 20 minutes later. The goal was to see how many pat…

This study tested a handheld microscope to look at tiny blood vessels in 68 adults with sepsis or septic shock. The goal was to understand how these vessels break down during severe infection, which could help doctors design better treatments in the future. Participants were moni…

This study looked back at 200 ICU patients with septic shock to see if using a bedside ultrasound (POCUS) as part of routine care improved their outcomes. Researchers compared patients treated before and after the ultrasound program started. The goal was to see if ultrasound help…

This study looked at 80 adults in the ICU with septic shock to see if increasing their blood pressure from 65 mmHg to 85 mmHg helps protect their kidneys. Researchers measured kidney blood flow and checked for kidney injury. The goal was to learn if a higher blood pressure target…

This study looked at two blood markers—nCD64 and mHLA-DR—in 76 adults with septic shock, a life-threatening infection that can cause organ failure. Researchers took blood samples on day 1 and day 8 to see how these markers changed over time and whether they could tell apart survi…

This study looked at how platelets (small blood cells that help with clotting) become activated in people with septic shock, a severe infection that can cause organ failure. Researchers measured specific markers on platelets and platelet-white blood cell clumps in 27 patients. Th…

This study looked at 40 adults with septic shock (a severe infection causing very low blood pressure) to see if two blood markers, renin and DPP3, can predict who will respond better to a drug called angiotensin II versus standard blood-pressure-raising medicines. The goal was no…

This study looked at 80 adults with septic shock to see if a simple finger sensor (peripheral perfusion index) can accurately predict blood flow to tissues when different doses of the drug norepinephrine are used. The goal was to find out if the sensor's accuracy changes with dru…

This study looked at 150 adults with sepsis to see if a score called EASIX (based on routine blood tests) could predict who would die or have serious complications within 28 days. Researchers measured the score at the time of diagnosis and tracked outcomes like septic shock and k…

This study looked at 945 adults with septic shock in the ICU to see if giving blood pressure medicine based on body weight works better than a standard dose. The goal was to find out which method leads to better survival and fewer side effects. Results will help hospitals choose …

This study observed how fluids are given to nearly 5,000 critically ill adults in ICUs worldwide. It aimed to understand current fluid-giving practices and whether they affect patient outcomes. No new treatments were tested; instead, researchers gathered data to improve future ca…

This study examined how the heart's ability to pump and relax affects survival in people with septic shock, a life-threatening infection that causes organ failure. Researchers followed 440 intensive care patients, measuring heart function with ultrasound and tracking daily fluid …

This completed study involved 103 adults with septic shock, a life-threatening condition. Researchers measured levels of a protein called VEGF-A and tracked how much fluid patients retained. The goal was to see if higher VEGF-A levels are linked to more fluid buildup, which can w…

This study looked at whether a blood-filtering device called Efferon LPS removes antibiotics from the blood of people with sepsis. Sepsis is a severe infection that can lead to organ failure, and doctors sometimes use filters to help clean the blood. The goal was to measure how m…

This study looked at 52 adults with septic shock to understand why they lose muscle mass. Researchers measured a protein called PTP1B and a gut barrier marker called zonulin, linking them to muscle changes seen on ultrasound. The goal was to gather knowledge, not to test a new tr…

This study looked at the fluid between cells (interstitial fluid) in 26 intensive care patients with septic shock or other types of shock. The goal was to understand how this fluid changes during sepsis, which may explain why severe swelling occurs. Researchers measured component…

This study looked at how the body processes antifungal drugs (echinocandins) in 24 adults with septic shock caused by a serious abdominal infection (peritonitis). The goal was to measure drug levels in the blood to help doctors choose the right dose. It did not test a new treatme…

This study tested whether carefully limiting fluids given for maintenance, drug dilution, and nutrition (not for emergency resuscitation) could reduce fluid overload in intensive care patients with septic shock. Fifty adults participated, and researchers measured their fluid bala…

This study looked at 196 adults with septic shock in intensive care to see if a blood test measuring immature platelets could predict their risk of death or organ failure at 28 days. The goal was to find a cheap, routine test to identify high-risk patients early. The study did no…

This study looked at 124 people with septic shock to see if the difference between carbon dioxide levels in veins and arteries could predict who would get worse. Researchers monitored patients closely for three days and tracked organ failure and survival at 28 days. The goal was …

This study looked at how COVID-19 causes organ failure in intensive care patients. Researchers tracked 380 adults with suspected or confirmed COVID-19 in the ICU, measuring kidney injury, breathing problems, and survival rates. The goal was to better understand the disease, not t…