SEPTIC SHOCK

This study tests whether a standard set of emergency steps—like quick blood tests, fluids, and antibiotics—can improve survival for adults with sepsis or septic shock. Researchers will compare results from 74 patients treated before the new protocol to 46 patients treated after i…

This study tests a drug called sivelestat in 120 adults with septic shock and blood clotting problems. The drug aims to restore the body's ability to break down small clots, which may reduce organ damage. Participants will receive either the drug or a placebo for 24 hours, and do…

This pilot study tests whether using ultrasound to guide beta-blocker therapy is feasible in 100 adults with septic shock, a life-threatening infection causing low blood pressure and rapid heart rate. Participants will receive either the beta-blocker esmolol or standard care to s…

This study looks at whether giving hydrocortisone early can help children with septic shock survive and recover faster. About 122 children aged 2 months to 12 years will take part. Researchers will track deaths within 28 days and how long kids need ICU care and blood pressure sup…

This study compares two blood pressure medications—Angiotensin II and norepinephrine—in adults with septic shock, a life-threatening condition with up to 40% death rate. Researchers will enroll 78 participants to see which drug better restores normal blood pressure and reduces sh…

This pilot study tests whether adding fludrocortisone to usual hydrocortisone treatment helps control septic shock in 32 critically ill adults. Septic shock is a life-threatening condition where the body's response to infection causes dangerously low blood pressure. The main goal…

This study tests a blood purification treatment called Oxiris in 62 adults with septic shock (a severe infection causing organ failure). Participants will receive the filter for up to 3 days in the ICU, and researchers will check if it lowers the risk of death or organ problems w…

This study tests whether adding an experimental drug (NAI) to standard care can help critically ill sepsis patients with persistently low lymphocyte counts (a sign of immune weakness) survive longer. About 50 adults in the ICU will be randomly assigned to receive either NAI injec…

This study looks at two methods of giving a common type of antibiotic (beta-lactam) to adults with sepsis or septic shock in the ICU. One method gives the drug continuously over time, while the other gives it in short bursts. The goal is to see which approach helps more patients …

This study looks at whether giving extra human albumin—a natural protein in blood—along with usual treatments can help people with surgical septic shock survive longer. Septic shock is a life-threatening condition from severe infection that often requires surgery. The trial will …

This study looks at whether giving fluids and a blood pressure medication early can prevent kidney injury in adults with septic shock, a life-threatening infection. About 100 participants will receive a standard treatment plan. Researchers will measure kidney function and blood p…

This study tests whether dapagliflozin, a drug usually used for diabetes, can help people with septic shock—a life-threatening condition where blood flow to small blood vessels fails. About 568 adults in intensive care will receive either dapagliflozin or a placebo, alongside sta…

This study tests whether giving a calming drug called dexmedetomidine early can help people with septic shock. The drug aims to calm an overactive nervous system, reduce organ damage, and improve survival. About 168 adults will receive either the drug or a placebo for 48 hours, a…

This study checks whether a blood gas measurement (the difference in carbon dioxide between central veins and arteries) can accurately detect low cardiac output in 74 patients with septic shock from severe skin infections who are receiving hyperbaric oxygen therapy. The goal is t…

This study will compare two noninvasive methods—electrical cardiometry and echocardiography—for measuring how well the heart pumps blood in 100 adults with septic shock. The goal is to see if electrical cardiometry can be a reliable, easier-to-use alternative for monitoring these…

This study looks at whether the urea-to-creatinine ratio, a simple blood test, can help doctors understand the metabolic state of patients with septic shock. The goal is to see if this ratio can replace indirect calorimetry, a complex machine not always available in ICUs. Researc…

This study looks at how the thyroid and adrenal glands work in 200 ICU patients with septic shock, a life-threatening infection that causes organ failure. Researchers will measure hormone levels in the blood to see if these glands are affected. No new treatments are tested—the go…

This study looks at whether a special blood test measuring neutrophil fluorescence can help doctors quickly identify which emergency patients with infections are at risk for severe sepsis, septic shock, or organ failure. Researchers will compare the test results to standard metho…

This study will observe 400 adults with sepsis (a severe infection) who need medication to keep their blood pressure up. Researchers will check their heart function and blood vessel health within 72 hours of hospital admission. The goal is to see if certain patterns of heart and …

This study watches how the heart responds to two common treatments for septic shock: extra fluids or blood-pressure-raising medications. Researchers will use heart ultrasounds before and after treatment in 180 adults. The goal is to learn which approach works better for improving…

This study tests whether a Chinese herbal medicine called Shenfu Injection can improve blood flow in patients with septic shock, a life-threatening condition. Twenty adults in the ICU will receive the injection, and doctors will measure changes in their circulation and oxygen lev…

This study aims to create a predictive model that helps doctors quickly identify which sepsis patients in the emergency department are likely to have drug-resistant infections. By analyzing data from 10,000 adults, researchers hope to improve antibiotic selection, reduce the spre…

This study looks at a new device that can measure a substance called nucleosomes in the blood right at the patient's bedside. Researchers want to see if these levels can help predict which critically ill patients will survive for 30 days. The study will include 130 adults in the …

This study will observe 5,000 adults in intensive care with septic shock to see how doctors actually treat them. It aims to understand if hospitals follow published guidelines and what factors influence care. No new treatments are tested; instead, researchers will collect data to…

This study looks at small molecules called microRNA in the blood of 56 adults with septic shock. The goal is to learn how these molecules relate to immune system problems that can lead to more infections or death. It does not test a new treatment, but aims to gather knowledge for…

This study looks at whether muscle measurements from a CT scan taken when a patient enters the ICU can help predict who will survive for 3 months after leaving the ICU. Researchers will study 196 adults with septic shock. The goal is to see if muscle size and quality are linked t…

This study aims to find the best way to dose the antibiotic ceftazidime for patients in intensive care with serious infections. Standard dosing often leads to levels that are too low or too high. Researchers will test a personalized dosing plan based on each patient's kidney func…