SEPTIC SHOCK

This study tests a new blood-cleaning method called adaptive blood purification (ABP) for people with septic shock, a life-threatening condition. The goal is to see if ABP, added to standard care, can reduce deaths within 90 days. About 276 adults in intensive care will be random…

This study looks at the best time to add a second blood pressure medicine (vasopressin) for people with life-threatening infections causing very low blood pressure (septic shock). About 2,050 adults in hospital emergency or inpatient units will be treated using either an earlier …

This study tests whether adding a special blood filter (PMX cartridge) to usual care helps people with septic shock caused by endotoxins. About 150 adults with low blood pressure needing strong medications will be randomly assigned to get the filter plus standard care or standard…

This study tests a blood purification device in 15 critically ill adults with septic shock (a severe infection causing low blood pressure). The goal is to see if filtering the blood can help patients recover faster and leave the ICU sooner. The treatment is given alongside standa…

This study tests a drug called ivabradine in 429 adults with septic shock, a life-threatening infection that causes dangerously fast heart rates. Unlike standard treatments, ivabradine lowers heart rate without weakening the heart's pumping ability or dropping blood pressure. The…

This study compares a drug called Angiotensin II to the usual treatment for raising blood pressure in people with liver disease who have a dangerous drop in blood pressure (shock). The goal is to see if Angiotensin II helps the heart and blood vessels work together better. About …

This study looks at whether a blood test called Monocyte Distribution Width (MDW) can help doctors quickly identify patients with bloodstream infections (bacteremia) in the emergency department. Researchers will check how well MDW levels predict positive blood cultures in 50,000 …

This study looks at whether starting continuous kidney therapy (CRRT) early can help children with septic shock recover faster. Researchers will track 50 children in the ICU to see how their blood pressure, organ function, and inflammation levels change. The goal is to gather evi…

This study looks back at hospital records of over 31,000 people in Catalonia, Spain, who had septic shock between 2018 and 2023. Researchers want to find out how common it is, who gets it, and how many people die from it in the hospital. The goal is to help hospitals improve care…

This study looks at how sepsis, a severe infection, can damage the heart. Researchers will monitor about 330 adults with septic shock in the ICU, using heart scans, blood tests, and other measurements. The goal is to find patterns that help doctors better diagnose and predict out…

This study tests whether metformin, a common diabetes medicine, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers will enroll 80 intensive care patients to monitor side effects and see if the treatment can be given successfully. This is a…