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Can early blood filtering help kids with septic shock?

NCT ID NCT07370753

Knowledge-focused Sponsor: National Children's Hospital, Vietnam Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 50 children with septic shock who receive early continuous renal replacement therapy (CRRT), a type of blood filtering. Researchers want to see if early CRRT helps stabilize blood pressure, reduce organ damage, and improve recovery. The goal is to gather information on how and when to best use this treatment in critically ill children.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
continuous renal replacement therapy (CRRT)
What this could lead to
If successful, this could point toward better timing for using CRRT in children with septic shock, potentially improving survival and recovery.
What could go wrong
This is a small observational study, not a randomized trial, so it cannot prove cause and effect. Results may not apply to all children with septic shock.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pediatric patients with septic shock admitted to the PICU and receiving early continuous renal replacement therapy as part of routine clinical care

Ages

1 month to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age from 1 month to \<18 years * Diagnosis of septic shock according to Phoenix Sepsis Criteria, defined as: * Phoenix Sepsis Score ≥ 2, and * Presence of circulatory dysfunction * Fulfillment of at least one of the following: * Acute kidney injury KDIGO stage 2 or higher * Requirement for vasoactive support with Vasoactive-Inotropic Score (VIS) ≥ 50 * Admission to a Pediatric Intensive Care Unit (PICU) * Written informed consent obtained from parent(s) or legal guardian(s) Exclusion Criteria: * Expected survival \<24 hours at time of screening o End-stage organ failure, including: End-stage renal disease requiring chronic dialysis or eGFR \<15 mL/min/1.73 m² * End-stage liver disease * End-stage heart failure * Known immunosuppression, including HIV infection or primary immunodeficiency disorders * Emergency indications for CRRT unrelated to septic shock (e.g., severe hyperkalemia, severe dysnatremia, symptomatic uremia, or fluid overload \>10%) * PICU length of stay \<24 hours * CRRT duration \<6 hours

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Conditions

The condition(s) this trial relates to.

multiple organ dysfunction syndrome toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pediatric sepsis-induced multiple organ dysfunction syndrome Septic shock

Contacts and locations

Locations

  • Vietnam National Children's Hospital

    Hanoi, Vietnam

More trials for these conditions

Other studies related to the condition(s) this trial covers.