Personalized antibiotic dosing could save lives in the ICU
NCT ID NCT07085624
First seen Jun 27, 2026 · Last updated Sep 17, 2026 · Updated 2 times
Summary
This study aims to find the best way to dose the antibiotic ceftazidime for patients in intensive care with serious infections. Many ICU patients don't get enough of the drug because their bodies process it differently. The researchers will test a personalized dosing plan to keep antibiotic levels effective but safe. About 128 adults will take part.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 128 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusionn criteria: * Patient hospitalized in intensive care unit for an expected duration of at least 72 hours, with an infection for which initiation of ceftazidime therapy is being considered. * Patient with an arterial catheter for blood sampling. * Patients affiliated to or entitled under a social security scheme. Exclusion Criteria: * Pregnant woman, parturient, nursing mother; * Person deprived of liberty, hospitalized without consent, * Adults under legal protection (guardianship-curatorship) * Patients undergoing extra-renal purification or whose CKD-EPI at the start of treatment is less than 15 ml/min.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
8 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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CHU GRENOBLE, Médecine intensive
Grenoble, 38043, France
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CHU Nord, Médecine intensive et réanimation
Marseille, 13915, France
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CHU ST-ETIENNE - Médeine Intensive Réanimation
Saint-Etienne, 42055, France
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CHU ST-ETIENNE, Médecine intensive Réanimation B
Saint-Etienne, 42055, France
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CHU ST-ETIENNE, Réanimation Néphrologie
Saint-Etienne, 42055, France
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HCL Croix Rousse, Médecine intensive réanimation
Lyon, 69004, France
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HCL Hôpital Edouard Herriot, Médecine intensive et réanimation
Lyon, 69437, France
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HCL Hôpital Lyon Sud, Médecine intensive réanimation
Pierre-Bénite, 69495, France
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