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Scientists probe hidden fluid to unlock septic shock mysteries

NCT ID NCT05039151

Knowledge-focused Sponsor: Centre Hospitalier Universitaire Dijon Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the fluid between cells (interstitial fluid) in 26 intensive care patients with septic or non-septic shock. Researchers aimed to understand how this fluid changes during severe infections, which could help explain why swelling occurs and how to better manage fluids in the future. No new treatments were tested; the goal was simply to gather knowledge.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

26 people

The number who actually took part.

Started

Jan 2021

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

ligible patients will be identified among patients admitted to Intensive Care Medicine

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: COMMON INCLUSION CRITERIA * Patient under mechanical ventilation and sedation * Patient and/or trusted person (health care proxy) or close relative who has given their oral consent after being informed, * Age ≥ 18 years old, INCLUSION CRITERIA FOR THE SEPTIC SHOCK GROUP * Diagnosis within 24 hours of admission of septic shock as defined by : * A probable or confirmed infection * And a SOFA score ≥ 2 * And the need to introduce vasopressors to obtain a MAP ≥ 65 mmHg despite adequate vascular filling * And an arterial lactate \> 2 mmol/l * Norepinephrine dose greater than 0.1 μg/kg/min * Septic shock present for less than 48 hours INCLUSION CRITERIA FOR THE CONTROL GROUP \- Absence of sepsis and shock from any cause within 2 months prior to inclusion Exclusion Criteria: * Disseminated intravascular coagulation (DIC) with haemorrhagic syndrome * Acute condition that can mimic sepsis : * Acute pancreatitis without signs of superinfection * Metformin Intoxication * Patient with an unfavourable prognosis within 24 hours * Patient under legal protection (safeguard of justice, guardianship or tutelage) * Pregnant or breastfeeding women * Patient not affiliated to national health insurance

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Conditions

The condition(s) this trial relates to.

toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Interstitial liquid Septic shock

Contacts and locations

Locations

  • Chu Dijon Bourgogne

    Dijon, 21000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.