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Heart pumping problems linked to worse outcomes in septic shock

NCT ID NCT02918214

Knowledge-focused Sponsor: University Hospital, Limoges Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 440 ICU patients with septic shock to see how their heart's pumping and relaxation abilities affected survival. Researchers measured heart function using ultrasound and tracked fluid balance. The goal was to better understand which heart problems are linked to higher risk of death, so doctors can improve care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better predict outcomes and manage fluid levels in septic shock patients.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly lead to new therapies. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

440 people

The number who actually took part.

Started

Jan 2017

Finished

Oct 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients will be recruited in the ICU but also in Emergency Departments if they present with septic shock before ICU admission

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient hospitalized in ICU for septic shock: * Documented or highly suspected infection (clinically or microbiologically) * Causing an organ failure defined as an acute change in total SOFA score ≥ 2 points (baseline SOFA score can be assumed to be zero in the absence of pre-existing organ dysfunction) * And low blood pressure (sBP \< 90 mmHg or a decrease of more than 40 mmHg compared to baseline, or mBP \< 65 mmHg) despite a fluid loading of 30 mL/kg (except if clinical or radiological sign of pulmonary fluid overload) requiring vasopressor infusion to maintain mBP \> 65 mmHg * And lactate level \> 2 mmol/L * Patient older than 18 years old affiliated to the French Social Security * Non-opposition of the patient (or of its next-of-kin) to participate in the study Exclusion Criteria: * Ongoing dobutamine or epinephrine infusion * Severe left valvular disease (severe stenosis, severe regurgitation ≥ grade 3) * Constrictive pericarditis (invalidate the mitral tissue Doppler imaging) * Pregnant women * Patient with estimated life expectancy \< 24h.

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Conditions

The condition(s) this trial relates to.

Hyperkinesis toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diastolic dysfunction Echocardiography Hyperkinesia Septic shock

Contacts and locations

Locations

  • Aphp - Ambroise Paré

    Paris, 75010, France

  • CH d'Orleans

    Orléans, 45000, France

  • CHU de Nancy

    Nancy, 54511, France

  • CHU de Poitiers

    Poitiers, 86021, France

  • Felix Guyon Hospital

    Saint-Denis, 97405, France

  • University Hospital

    Amiens, 80000, France

  • University Hospital

    Brest, 29200, France

  • University Hospital

    Limoges, 87042, France

  • University Hospital

    Toulouse, 31000, France

  • University Hospital

    Tours, 37000, France

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