CARDIOGENIC SHOCK

This study tests whether giving a special life-support machine (ECMO) at the scene of a cardiac arrest helps more people survive than waiting until they reach the hospital. About 90 adults under 70 who have a witnessed heart attack and receive bystander CPR will be included. The …

This study looks at whether using less of the drug noradrenaline by aiming for a lower blood pressure (≥55 mmHg) can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults who have had a heart attack and are in sh…

This study tests whether setting a personalized blood pressure goal based on vein pressure improves outcomes for adults in cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 406 participants will receive either standard care or a tailor…

This study tests whether using a heart-lung machine (ECMO) before a complex valve replacement can prevent death, cardiac arrest, or emergency surgery in high-risk patients with severe aortic stenosis. About 30 adults who are unstable or have tricky heart anatomy will receive this…

This study tests a heart-lung support device (Cardiohelp) in 50 children with severe heart failure to see if it is safe and effective for up to 30 days. It also compares two blood thinners (heparin vs. bivalirudin) to find which causes fewer bleeding or clotting problems. The goa…

This study tests a temporary heart pump (iVAC 2L) in 100 people with severe coronary artery disease who need high-risk angioplasty. The pump helps keep blood flowing during the procedure, which may reduce the chance of death, heart attack, or stroke. The goal is to see if the dev…

This study tests whether a special heart monitor can help prevent serious problems in people who have survived a severe form of heart failure called cardiogenic shock. The monitor tracks pressure in the artery leading to the lungs. The goal is to see if this monitoring reduces de…

This study tests whether using a special heart monitor (pulmonary artery catheter) early in people with cardiogenic shock from heart failure lowers the risk of dying in the hospital. About 400 adults will be randomly assigned to get the monitor or standard care. The goal is to se…

This study tests a temporary heart pump (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The pump is inserted through the skin to help the left ventricle work better. The goal is to see if it's safe and c…

This study tests whether starting kidney dialysis earlier, rather than waiting, helps people with severe heart shock who are on a heart-lung machine (ECMO). About 408 adults with both heart and kidney failure will be randomly assigned to early or standard dialysis. The main goal …

This study looks at whether adding a special balloon pump (IABP) to standard ECMO support helps people with severe heart failure recover more quickly. About 430 adults in cardiogenic shock will be randomly assigned to get ECMO alone or ECMO plus the pump. The main goal is to see …

This study looks at adults hospitalized with severe heart failure or cardiogenic shock. Researchers will collect information from routine care, plus blood and urine samples, to see if they can better identify different types of heart failure and predict who is at higher risk of d…

This study is for people with cardiogenic shock, a serious condition where the heart suddenly can't pump enough blood. Researchers want to understand why some people respond differently to treatment by looking at their genes and immune system. They will collect blood samples and …

This study follows 350 people who survived cardiogenic shock (a severe heart condition) after leaving the hospital. Researchers want to learn about their long-term health, including risks of death or readmission. The goal is to build a support network to help survivors return saf…

This study is for adults in cardiogenic shock who need a temporary heart pump called an intra-aortic balloon pump (IABC). Researchers want to see if the stiffness of a person's arteries affects how well the pump works. They will measure blood flow and other vital signs before, du…

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify patterns. The goal is to improve care for future patients, not to test a new tre…

This study is not testing a new drug or device. Instead, it will track 500 people with cardiogenic shock (a life-threatening condition where the heart suddenly can't pump enough blood) at four specialized hospitals. Researchers will collect detailed information on treatments and …

This study looks back at medical records of 3,000 people who had cardiogenic shock—a life-threatening condition where the heart suddenly can't pump enough blood. Researchers want to see if survival rates improved after a special shock team started working at the hospital in 2017.…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…