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Scientists track hidden body changes during sepsis after surgery

NCT ID NCT07442552

Knowledge-focused Sponsor: Carol Davila University of Medicine and Pharmacy Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how sepsis (a severe infection) changes the body's inflammation, blood clotting, heart function, and certain genetic markers in 40 adults after major abdominal surgery. Researchers compare patients who develop sepsis with those who do not, using blood tests and heart scans before and within 24 hours after surgery. The goal is to better understand these changes and find early warning signs of sepsis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population includes adult patients (≥18 years) undergoing elective or emergency major abdominal surgery at a single academic university hospital. Eligible patients must be hemodynamically stable in the preoperative period, able to provide written informed consent, and have biological samples available both before surgery and within 24 hours postoperatively. A total of 40 patients are prospectively enrolled and followed during the perioperative period only. The patients are devided into septic or non-septic.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Undergoing major abdominal surgery (elective or emergency) * Ability to provide written informed consent * Availability of biological samples in the preoperative period and within 24 hours postoperatively * Preoperative hemodynamic stability Exclusion Criteria: * Surgical reintervention within 3 months after the index procedure * Multiple surgical procedures during the same hospitalization * Active chronic infections (HIV, active viral hepatitis, tuberculosis) * Autoimmune or systemic inflammatory diseases * Chronic immunosuppressive therapy or long-term corticosteroid use * Severe hepatic failure (Child-Pugh class C) * End-stage renal disease requiring dialysis * Severe pre-existing cardiac disease (NYHA class III-IV heart failure) * Pregnancy * Refusal or inability to provide informed consent

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Intraabdominal Infections

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sepsis abdominal

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Institutul Clinic Fundeni

    RECRUITING

    Bucharest, Sector 2, 022328, Romania

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