Heart MRI may reveal hidden damage in young cancer survivors after sepsis
NCT ID NCT05930418
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested whether a heart MRI could be done safely and effectively in children with cancer who recently had sepsis. The goal was to see if the MRI could find hidden heart inflammation or weakness that standard tests might miss. Only 7 children took part, and the focus was on whether the scan was possible, not on treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to better ways to detect and manage heart issues in children with cancer after severe infections.
- What could go wrong
- This is a very small pilot study (only 7 participants) focused on feasibility, so results may not apply broadly. It does not test a treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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7 people
The number who actually took part.
- Started
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May 2023
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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9 to 25 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Between 9 and 25 years of age at time of study enrollment * Currently receiving care for cancer at St. Jude * Diagnosed with sepsis according to Phoenix score Exclusion Criteria: * Participant has been diagnosed with clinically significant left ventricular dysfunction (EF \< 55%) prior to the onset of sepsis * Participant has any condition that would, in the opinion of the investigator, place the subject at an unacceptable risk of injury or render the subject unable to meet the requirements of the protocol. * Participant is pregnant * Estimated glomerular filtration rate \< 45 ml/minute/1.73m2 * Does not meet MRI safety screening criteria.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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