St. Jude Children's Research Hospital

This early-phase study tests whether fecal microbiota transplantation (FMT) is safe and feasible for children under 22 who have gut problems after a stem cell transplant. Ten participants will receive FMT via colonoscopy or a nasal tube. The main goal is to check for serious side…

This early-phase trial tests a new type of immune therapy called CD70-CAR T cells in children and young adults up to age 21 with blood cancers that have come back or not responded to treatment. The therapy involves taking the patient's own immune cells, engineering them to recogn…

This study tests the drug entrectinib in children under 3 with certain brain tumors (NTRK or ROS1 gene fusions). The goal is to see if the drug can shrink tumors and delay the need for chemotherapy. About 52 children will take entrectinib by mouth, and doctors will monitor tumor …

This study tests a new way to do a stem cell transplant for children with a hard-to-treat type of leukemia (ALL). Doctors will use special immune cells (CAR T cells) after the transplant to try to kill any remaining cancer cells. The goal is to see if this approach is safe and wo…

This study tests whether adding an experimental immune-boosting drug (N-803) to standard chemoimmunotherapy can help children and young adults whose neuroblastoma has returned or not responded to treatment. About 54 participants will receive the combination to see if it is safe a…

This early-stage study tests a new treatment for children and young adults up to age 21 with sarcomas that have come back or not responded to standard therapy. The treatment combines a special type of immune cell (B7-H3-CAR T cells) with targeted radiation and chemotherapy to see…

This study tests a drug called mirdametinib, which is designed to reach the brain and target a key growth signal in low-grade glioma cells. It is for children, adolescents, and young adults (ages 2 to 24) whose tumor has come back or is growing. The goal is to find the best dose …

This early-stage trial tests a new immunotherapy for children and young adults up to age 21 with solid tumors that have come back or not responded to standard treatment. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein…

This early-stage trial tests a new type of cell therapy for children and young adults up to age 21 with a form of leukemia (CD19-positive) that has returned or not responded to treatment. The therapy uses immune cells from a family donor that are engineered in a lab to recognize …

This study is for children and young adults (ages 1 to 30) whose solid tumors have come back or not gone away with standard treatment. It tests two different drug pairs: one combines Onivyde with talazoparib, the other Onivyde with temozolomide. Both work by damaging cancer cell …

This early-phase study tests a new way to give immune cells (T-cells) after a stem cell transplant in children with high-risk blood cancers. The goal is to see if giving special memory T-cells early can help fight cancer while reducing dangerous side effects like graft-versus-hos…

This study is for children and young adults (up to age 30) with a rare type of soft tissue cancer called non-rhabdomyosarcoma. It tests whether adding the drugs pazopanib and selinexor to standard chemotherapy can improve outcomes. Participants receive treatment tailored to their…

This study tests a personalized treatment plan for children under 5 with a type of brain cancer called medulloblastoma. Doctors use the tumor's genetic makeup and the child's age to choose the best mix of chemotherapy and, if needed, radiation. The goal is to improve survival whi…

This early-stage study tests whether adding a new drug called revumenib to two standard chemotherapy drugs is safe for children and young adults whose acute myeloid leukemia (AML) has not responded to treatment or has returned. The study involves 24 participants and aims to find …

This study tests a special cell therapy (CAR T) for children and young adults whose leukemia has not responded to standard treatments or has returned. About 25 participants will receive modified immune cells designed to attack cancer cells, along with chemotherapy to prepare the …

This early-phase study tests a new type of immune cell therapy (CAR T cells) that targets two proteins, CD19 and CD22, on leukemia cells. It is for children and young adults up to age 21 whose leukemia has returned or not responded to standard treatments. The main goal is to find…

This early-phase study tests the safety of a one-time gene-edited stem cell treatment for people with severe sickle cell disease. The therapy uses CRISPR technology to boost fetal hemoglobin, which may reduce painful crises and other complications. Up to 25 participants aged 18 t…

This early-stage trial tests a new treatment for children and young adults up to age 21 with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a pro…

This study tests whether adding dasatinib or venetoclax to standard chemotherapy can help more children with T-cell acute lymphoblastic leukemia or lymphoma achieve a deep remission. About 100 children and young adults aged 1 to 18 will receive one of these targeted drugs alongsi…

This early-phase trial tests a new treatment called CD123-CAR T cells for children and young adults (up to age 21) with certain types of leukemia or related blood cancers that have come back or not responded to standard therapy. The treatment involves collecting the patient's own…

This study tests a drug called CM4620 in children and young adults who develop pancreatitis (inflammation of the pancreas) from a chemotherapy drug called asparaginase. The goal is to see if CM4620 is safe and can prevent severe complications like pancreatic cysts or tissue death…

This study tests whether giving two targeted immunotherapy drugs (inotuzumab and blinatumomab) together at the start of treatment can eliminate leukemia cells more effectively than standard chemotherapy in children and young adults (ages 1-18) with newly diagnosed B-cell acute ly…

This study tests if a long-acting antibiotic called dalbavancin can prevent serious bloodstream infections in children and young adults with high-risk leukemia who are receiving strong chemotherapy. About 29 participants will receive the drug every 28 days. The goal is to see if …

This study tests whether specially selected immune cells from a donor can safely treat cytomegalovirus (CMV) and adenovirus (ADV) infections in children who have had a stem cell transplant. About 42 participants will receive these virus-fighting cells and be monitored for viral l…

This study tests a new way to give proton radiation to children with low-grade glioma, a common brain tumor. The goal is to avoid the hippocampus, a brain area key for memory, to reduce long-term memory loss. About 74 children will receive this targeted radiation, and researchers…

This study tests the safety and effectiveness of combining four drugs (cyclophosphamide, sorafenib, bevacizumab, and atezolizumab) in children and young adults up to age 30 with solid tumors that have come back or not responded to treatment. The trial has two parts: first, findin…

This study tests whether a precise type of radiation called proton beam therapy can treat Wilms tumor while causing less damage to healthy tissue. About 260 children with newly diagnosed Wilms tumor who need abdominal radiation will take part. The goal is to see if this approach …

This study tests whether a special type of immune cell, called B7-H3-CAR T cell, can help prevent bone cancer from returning in children with high-risk osteosarcoma. Participants receive the cells after completing standard chemotherapy. The goal is to see if this approach improve…

This study tests a weight loss program for adult survivors of childhood acute lymphoblastic leukemia (ALL) who are overweight or have obesity. Participants receive a weekly injection of tirzepatide plus remote, supervised resistance exercise three times a week for 28 weeks. The g…

This study looks at whether a wearable device and a questionnaire can spot autonomic dysfunction—a condition affecting automatic body functions like heart rate—in survivors of childhood leukemia and lymphoma. Researchers will compare these remote methods to standard in-person tes…

This program offers a special PET scan using a radioactive tracer called methionine to help doctors better see and manage central nervous system (brain, spine) and head/neck tumors in children and young adults. The scan provides extra information that can guide treatment decision…

This study tests whether a mobile app that teaches cognitive behavioral therapy (CBT) can reduce chronic pain and improve daily functioning in adolescent survivors of childhood cancer. Researchers will compare the app to standard pain education in 228 participants (teens and thei…

This pilot study at St. Jude Children's Research Hospital explores whether a guided writing exercise can help teenagers and young adults (ages 15-25) cope with their cancer experience. Participants will write about their experiences and then share their thoughts in an interview. …

This study tests whether children with sickle cell disease (SCD) who have trouble paying attention or thinking clearly can safely take a daily stimulant called methylphenidate for 4 weeks. The goal is to see if the medicine is easy to take, works well, and has few side effects. A…

This study looks at whether a 12-week high intensity interval training (HIIT) program is doable for young people who finished treatment for Hodgkin lymphoma within the last two years. About 20 survivors aged 10 to 25 will try the program to see if it helps improve their heart and…

This study tests a special cooling cap (Paxman scalp cooling device) to see if it can safely prevent hair loss in children and young adults receiving chemotherapy for non-cancerous conditions or solid tumors. About 40 participants will wear the cap during treatment. The goal is t…

This study tests whether virtual reality can make cognitive training more engaging and effective for children aged 8-22 who are receiving radiation for brain tumors. About 45 participants will be randomly assigned to do brain exercises on an iPad or in virtual reality. Researcher…

This study tests a small, non-invasive earbud that gently stimulates a nerve in the ear to help adult survivors of childhood leukemia who have trouble sleeping. About 40 participants will use either the active device or an inactive one nightly for up to 8 weeks. Researchers will …

This study looks at whether using virtual reality (VR) can help reduce pain in children and young adults with sickle cell disease who are having a painful crisis. About 76 participants, ages 6 to 25, will either get standard pain treatment alone or standard treatment plus VR. Res…

This study collects tumor samples from 500 children and teens with melanoma or related skin growths to analyze their genetic makeup. Researchers aim to learn more about what drives these rare childhood cancers. No new treatments are being tested; instead, the focus is on gatherin…

This study watches how spinal muscular atrophy (SMA) drugs change muscles and nerves in 24 children aged 5 to 20. Using MRI scans, strength tests, and blood samples, researchers track changes over a year. The goal is not to test a new treatment but to better understand how existi…

This study follows 80 children and young adults who received CAR T-cell therapy for B-cell acute lymphoblastic leukemia (B-ALL) at least two years ago. Researchers want to see how feasible it is to track their long-term health, including any new or lasting side effects, brain fun…

This study gathers opinions from patients, families, healthcare providers, and researchers about the ethical challenges of small-scale, personalized treatments for rare neurological diseases. Researchers will interview 385 participants to identify key concerns and best practices.…

This study looks at how serious walking problems are for children with bone or soft tissue cancer who had leg surgery. Researchers will use 3D cameras and sensors to measure movement and compare results to healthy kids of the same age. The goal is to understand how walking change…

This study collects health information from up to 30,000 children and adults who have or had childhood cancer at St. Jude Children's Research Hospital. The goal is to track their long-term outcomes and any late side effects from treatment. No new treatments are tested—this is pur…

This study looks at how parents and children (ages 10-24) talk about the child's genetic risk for cancer. Researchers want to find what helps or hinders these conversations, so they can create better education and support for families. About 125 participants will be observed and …

This study tests if a dye called Indocyanine Green (ICG) can help surgeons find lymph nodes that may contain cancer in children with solid tumors in the belly. About 25 children under 21 with Wilms tumor or a type of muscle cancer will get the dye during surgery. The goal is to s…

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a regist…

This study follows about 50,000 people who survived childhood cancer (diagnosed before age 21 between 1970 and 1999) and 10,000 of their siblings. Researchers want to learn how cancer treatments like radiation, chemotherapy, and surgery affect health years later. The goal is to b…

This study collects bone marrow that is normally thrown away during surgery from people with and without blood disorders like sickle cell disease. Researchers will use these samples in the lab to learn how to better manipulate stem cells for gene therapy and to study cell health.…

This study uses non-invasive MRI and MRS scans to measure how well muscle cells produce energy in adults who survived childhood acute lymphoblastic leukemia (ALL). Researchers will compare 60 survivors with low muscle mass to healthy volunteers. The goal is to understand why many…

This early-phase study tests a new radioactive tracer called [18F]-fluoromannitol in 10 healthy adults. The goal is to see if it is safe and how it spreads through the body during a PET scan. If all goes well, this tracer might one day help doctors find infections in people with …

This study follows 500 patients who have received genetically modified cell therapies at St. Jude Children's Research Hospital. The goal is to monitor for any delayed side effects or medical events over 15 years. Participants will have regular check-ins to track their health. Thi…

This study looks at how children with cancer (ages 12-25) and their families experience hope while taking part in early-phase clinical trials. Researchers will use photos and interviews to understand their hopes and challenges. The goal is to design better ways to support familie…

This study explores whether a short substance use questionnaire and brief counseling session can be easily added to regular check-ups for adult survivors of childhood cancer. About 30 participants will fill out a screening tool and, if needed, receive supportive counseling during…

This study looks at whether girls with sickle cell disease have lower levels of a hormone called AMH, which is linked to egg supply, compared to healthy girls of the same age and puberty stage. Researchers will also check how treatments and pain crises affect these levels. About …

This study is a worldwide registry that collects medical information, family cancer history, and tumor samples from children and teens with adrenocortical tumors. Researchers hope to better understand how these rare tumors develop, what treatments work best, and the role of the T…

This study talks to patients and parents of children with rare diseases like sickle cell disease to learn what they think and want to know about gene therapy. Researchers will use these conversations to build an online tool with clear information and decision aids. The goal is to…

This study aims to see if a communication skills training program designed for rehabilitation professionals (like physical and speech therapists) is practical and helpful. About 25 staff members at St. Jude Children's Research Hospital will take part. The goal is to boost their c…

This study tests a school readiness program for children aged 3.5 to 6.5 years with sickle cell disease. The program is designed to help prepare them for school. Researchers will check if the program is easy to use and if it helps improve school readiness skills compared to usual…

This study looks at why the heart gets damaged in people with sickle cell disease. Researchers will use special PET scans to measure blood flow to the heart during rest and stress. They will compare results from 40 young adults—some with sickle cell disease and some without—to se…

This study looks at how sleep problems affect memory and thinking in teens (ages 12-18) with sickle cell disease. Participants will use a home sleep monitor and complete thinking tests during a clinic visit. The goal is to understand the link between nighttime oxygen levels and b…

This study looks at how a child's genes influence the way their body processes medicines. Researchers will analyze DNA from up to 8,800 participants, including children with serious illnesses, their family members, and healthy volunteers. The goal is to understand why some childr…

This study collects and stores samples of tissue and body fluids from patients, their relatives, and healthy volunteers at St. Jude Children's Research Hospital. The goal is to create a large, organized bank of samples and related health information that researchers can use to be…

This study follows 10,000 childhood cancer survivors over their lifetime to understand long-term health effects from cancer treatments. Participants must be at least five years past diagnosis. Researchers will track medical, social, and behavioral factors to improve screening and…

This study follows 100 children and young adults who received CAR T cell therapy to understand short- and long-term side effects like infections, slow blood cell recovery, and nerve problems. Researchers will check participants at 3, 6, 12, and 24 months after treatment. The goal…

This early-stage study tests whether the drug motixafortide is safe for people with sickle cell disease and whether it can increase the number of stem cells that can be collected from their blood. These stem cells could be used in future gene therapies or transplants. The study i…

This study collects information directly from people (ages 8 and older) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) about their symptoms and quality of life. Participants will fill out surveys over time to help researchers understand how the disease and its treat…

This study looks at Hodgkin lymphoma survivors who had chest radiation and bleomycin treatment as children. Researchers want to understand how these treatments affect blood flow to the brain and heart-lung function during exercise. About 100 survivors and healthy volunteers will …

This study is testing whether a green dye called ICG can help surgeons see tumors more clearly during surgery in children and teens with solid tumors. The dye is injected before surgery and makes tumor tissue glow under a special camera. The goal is to see if this technique helps…

This study aims to understand how well the seasonal flu vaccine works in children with blood cancers like leukemia. Researchers will measure the immune response in up to 150 children at St. Jude Children's Research Hospital. The goal is to see if the vaccine triggers enough prote…

This study follows 56 adolescents and young adults who have a genetic condition that raises their cancer risk. Researchers want to see if these patients find adult doctors and continue getting regular cancer screenings after they leave pediatric care at St. Jude Children's Resear…

Childhood cancer survivors who had certain treatments are at higher risk for heart problems. This study tests an online education program to encourage them to get a recommended heart screening test. Researchers will compare the program to standard care in 350 survivors to see if …

This study talks to parents and teens with sickle cell disease to learn what they think about genetic research and gene therapy. Researchers will use surveys and interviews to understand concerns and expectations. The goal is to create better educational tools and build trust bet…

This study aims to learn more about the genetic and immune characteristics of several types of solid tumors in children, including neuroblastoma, osteosarcoma, and Ewing sarcoma. Researchers will collect tumor and blood samples from up to 1,000 participants to analyze genes, prot…

This study is testing a new way to help teenagers with hard-to-treat cancers, their parents, and their doctors have better conversations about what the future may hold. Researchers want to see if this approach is practical and helpful for everyone involved. About 85 people will t…

This study follows 184 people who survived medulloblastoma (a type of brain tumor) after receiving radiation therapy. Researchers want to learn about long-term health problems like memory issues, hearing loss, heart and hormone problems, and physical fitness. The goal is to find …

This study collects blood, bone marrow, and other samples from up to 1,716 people with non-cancerous blood diseases and their family members. Researchers will analyze genes to find causes of these diseases and why some people get sicker than others. The goal is to improve future …

This study follows up to 10,000 people with sickle cell disease over many years, starting in childhood and continuing into adulthood. Researchers collect health data and blood samples during regular clinic visits to learn how treatments like hydroxyurea affect long-term organ fun…

This study looks at the reasons parents consider when deciding whether to enroll their child in a cancer clinical trial. Researchers will survey and interview 400 parents of children newly diagnosed with cancer. The goal is to understand how social factors, personal preferences, …

This study is collecting and analyzing the complete genetic information (genomes) of up to 2,500 children with cancer. The goal is to learn how gene changes cause different tumors and affect treatment outcomes. This is a non-therapeutic study, meaning it does not test a new treat…

This study looks at how young adult survivors of childhood leukemia feel about exercise, using a special computer test and interviews. About 125 survivors who are not very active will take part. The goal is to see if this test can help understand their emotions and thoughts about…

This study enrolls children and teens (ages 1-18) newly diagnosed with certain types of leukemia or lymphoma. The main goal is to gather enough information from their tumor samples to figure out their risk of the cancer coming back, so they can be placed into the right treatment …