St. Jude Children's Research Hospital

This study tested different treatments tailored to each child's eye cancer (retinoblastoma). It included 107 children with cancer in one or both eyes. The goal was to cure the cancer, save the child's life, and preserve as much vision as possible using chemotherapy, focal treatme…

This pilot study tested whether memantine, a drug used for dementia in adults, could help prevent memory and thinking problems in children receiving brain radiation for tumors like glioma or craniopharyngioma. 41 children aged 6-21 took either memantine or a placebo during radiat…

This early-phase study tested a new way to do stem cell transplants in 23 children whose solid tumors or lymphomas had come back. The method uses a special filter to remove certain immune cells from the donor's stem cells, aiming to help the child's body recover faster. The main …

This study looked at whether keeping blood pressure very well controlled (lower than usual) could reduce the risk of a painful bone condition called osteonecrosis in children and young adults being treated for leukemia or lymphoma. 51 participants were randomly assigned to either…

This study tested a new gene therapy for adults with severe hemophilia B, a bleeding disorder caused by a faulty gene. The treatment uses a harmless virus to deliver a working copy of the factor IX gene, aiming to reduce bleeding episodes. Fourteen participants received one of fo…

This study tested a drug called avelumab in 19 children and young adults (ages 12-49) whose osteosarcoma (a type of bone cancer) had come back or was not responding to standard treatments. The goal was to see if avelumab could shrink tumors or stop the cancer from growing for at …

This study tested a new antibody (hu14.18K322A) added to standard chemotherapy for 153 children with high-risk neuroblastoma, a serious nerve tissue cancer. The goal was to see if the combination improves tumor shrinkage and delays the cancer from coming back. While the treatment…

This study tested a personalized exercise plan delivered at home via telehealth for childhood cancer survivors who have trouble exercising due to past treatment. 181 survivors took part to see if the program could improve their exercise capacity, heart and lung function, and qual…

This study looked at whether a mobile cognitive behavioral therapy (CBT) program, combined with a gentle brain stimulation technique called tDCS, could help teens who survived bone cancer manage chronic pain. Researchers first adapted the program for Black and Hispanic teens, the…

This study tested an internet-based program to help adult survivors of childhood cancer who have trouble sleeping. Over 1,500 participants used an online insomnia treatment designed to improve sleep and thinking skills. The goal was to see if better sleep could also boost memory,…

This pilot study tested whether a heart MRI could be done safely and effectively in children with cancer who recently had sepsis. The goal was to see if the MRI could find hidden heart inflammation or weakness that standard tests might miss. Only 7 children took part, and the foc…

This study looked at how well COVID-19 vaccines work in 21 children and young adults (under 24) with cancer or who had a transplant or cellular therapy. Researchers measured antibody and T-cell responses after vaccination. The goal was to understand vaccine effectiveness in these…

This study looked at whether health questionnaires filled out by childhood cancer survivors and their parents match what doctors find during check-ups. About 300 survivors aged 8 to 18 took part, completing surveys over three years. The goal is to make these questionnaires more a…

This study looked at the tiny organisms (bacteria and fungi) living in the mouth and nose of children with leukemia or those getting a bone marrow transplant. Researchers wanted to see how these germ communities change during chemotherapy. The goal was to learn more, not to test …

This study interviewed 150 people with hemophilia B, their caregivers, and healthcare workers from around the world to learn what they know and how they feel about gene therapy. The goal is to create better educational materials and improve the consent process, especially in coun…

This study looked at how children who survived brain tumors interact with others. Researchers tested their thinking and social skills to see what helps or hurts their friendships. The goal was to learn more, not to test a new treatment.

This study looked at children and young adults under 24 who had COVID-19, including those with cancer. Researchers collected samples and medical information to learn about symptoms, risk factors, and how the virus spreads. The goal was to better understand the disease in younger …

This study followed 94 young people with sickle cell disease as they moved from pediatric to adult medical care. Researchers tracked hospital visits, medication use, and quality of life to find out what makes this transition successful. The goal is to improve programs that help p…

This study looked at whether a special MRI (DW-MRI) that uses no radiation can work as well as standard scans like CT and PET-CT for children with bone or soft-tissue sarcomas. About 98 children participated to see if the MRI can accurately detect tumors and show how well treatme…

This study aimed to understand how stigma affects children with cancer and their caregivers. Researchers developed two new tools to identify and measure stigma in pediatric cancer patients and their guardians. The tools were tested in the United States, Guatemala, and Jordan with…

This pilot study looked at whether a commercial wrist monitor (WHOOP) can reliably measure resting heart rate and heart rate variability in adult survivors of childhood Hodgkin lymphoma who had chest radiation. About 34 participants wore the device at home and also had in-office …

This study involved 20 parents whose children received hospice care at St. Jude. Parents took or selected photos that represented hope during that difficult time, then discussed them in interviews. The goal was to better understand parents' emotions and experiences, not to test a…