St. Jude Children's Research Hospital

This study is for children, teens, and young adults with a type of leukemia that has not responded to standard treatments. It uses a special therapy where a patient's own immune cells are collected, modified to recognize and attack cancer cells, and then given back. The main goal…

This study is for children and young adults (up to age 30) with a rare type of soft tissue cancer called non-rhabdomyosarcoma. It tests whether adding the targeted drug pazopanib (and another drug, selinexor, for high-risk patients) to standard chemotherapy and radiation can impr…

This study tests a drug called CM4620 in children and young adults who develop pancreatitis (inflammation of the pancreas) after receiving a chemotherapy drug called asparaginase. The goal is to see if CM4620 is safe and can reduce the severity of pancreatitis, preventing serious…

This study is for children who have had a stem cell transplant and still have a cytomegalovirus or adenovirus infection that won't go away with standard treatment. Researchers want to see if giving special infection-fighting cells from the original donor can safely lower the amou…

This early study is testing whether fecal microbiota transplantation (FMT) is safe and doable for children who have ongoing gut issues after a stem cell transplant. The researchers will give FMT to 10 children and watch for side effects and symptom improvement. The goal is to see…

This study tests whether tailoring treatment based on the tumor's genetic makeup can improve outcomes for children under 5 with medulloblastoma. About 130 participants will receive different combinations of chemotherapy and, in some cases, radiation. The goal is to increase survi…

This early-stage study tests a drug called motixafortide in 15 adults with sickle cell disease. The goal is to see if it is safe and helps the body release more stem cells into the blood for collection. These stem cells could be used for future transplants or gene therapy to cont…

This early-stage study tests whether adding a new drug called revumenib to two standard chemotherapy drugs is safe for children and young adults whose acute myeloid leukemia (AML) has not responded to treatment or has returned. About 24 participants will receive the three-drug co…

This early-stage study tests whether a new treatment combining radiation and specially engineered immune cells (B7-H3-CAR T cells) is safe for children and young adults up to age 21 with sarcomas that have returned or not responded to standard therapy. The treatment aims to help …

This early-stage study tests whether a single infusion of a patient's own gene-edited stem cells is safe for young adults with severe sickle cell disease. The editing aims to boost fetal hemoglobin, which may reduce painful crises and other complications. Up to 25 participants ag…

This study tests a new treatment called CD70-CAR T cells for children and young adults up to age 21 with blood cancers like leukemia, lymphoma, or MDS that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to…

This early-stage trial tests a treatment made from a child's own immune cells, modified to target a protein called B7-H3 found on many brain tumors. The cells are delivered directly into the brain through a small tube. The study includes up to 48 children and young adults with ce…

This early-stage study tests a treatment where a child's own immune cells are collected, modified to better recognize and attack certain solid tumors, and then given back as a one-time infusion. The main goal is to find the safest dose and see if it can shrink tumors. The study i…

This study tests a new treatment approach for children and young adults (ages 1-18) with newly diagnosed B-cell acute lymphoblastic leukemia or lymphoma. The treatment uses two targeted drugs, inotuzumab and blinatumomab, during the first phase of therapy to try to achieve a deep…

This study tests a new way to do stem cell transplants for children with a high-risk type of leukemia (CD19+ ALL) that has come back or not responded to treatment. Doctors will use a special type of donor cells (from a partially matched family member) and then give the child an e…

This study tests a combination of four drugs (cyclophosphamide, sorafenib, bevacizumab, and atezolizumab) in children and young adults up to age 30 whose solid tumors have come back or not responded to standard therapy. The goal is to find safe doses and see if the combination ca…

This study tests a new treatment for children and young adults (up to age 21) with a type of leukemia (CD19-positive) that has returned or not responded to standard therapy. The treatment uses specially engineered immune cells from a family donor to attack the cancer. The main go…

This study tests a monthly antibiotic called dalbavancin to prevent serious bloodstream infections in children and young adults with high-risk leukemia who are receiving strong chemotherapy. About 29 participants will receive the drug every 28 days for up to 12 weeks. The goal is…

This study looks at whether a wearable device and a questionnaire can accurately detect autonomic dysfunction (a nerve problem affecting heart rate and digestion) in survivors of childhood leukemia and lymphoma. Researchers will compare these remote methods to standard in-person …

This program gives children and young adults with known or suspected cancer in the brain, head, neck, or spine access to a special PET scan using a tracer called methionine. The scan helps doctors get more detailed images to guide treatment decisions. There is no age limit, and a…

This study tests whether using virtual reality (VR) alongside standard pain medicine can reduce pain during a sickle cell crisis in children and young adults aged 6 to 25. Participants will either receive standard care alone or standard care plus VR therapy. Researchers will meas…

This study looks at whether a creative writing exercise can improve well-being for teenagers and young adults (ages 15-25) who are currently being treated for cancer. Researchers at St. Jude Children's Research Hospital want to see if participants find the writing activity valuab…

This study tests whether children with sickle cell disease can safely take a daily stimulant (methylphenidate) for 4 weeks to improve attention, thinking, and school performance. About 72 children aged 8 to 17 will participate. The goal is to see if the treatment is practical and…

This study tests whether a mobile app (WebMAP Onc) that teaches coping skills can reduce chronic pain and improve daily life in teens who survived childhood cancer. About 228 participants (teens and their caregivers) will be randomly assigned to use the app or receive standard pa…

This study is testing whether a 12-week high-intensity interval training (HIIT) program is doable for young people who finished treatment for Hodgkin lymphoma within the last two years. About 20 survivors aged 10 to 25 will take part. The goal is to see if they can stick with the…

This study tests a new way to give proton radiation to children with low-grade glioma, a common brain tumor. The goal is to avoid the hippocampus, a brain area key for memory, to reduce long-term memory problems. About 74 children will receive this targeted radiation, and researc…

This study follows about 50,000 people who survived childhood cancer (diagnosed before age 21 between 1970 and 1999) to learn about their long-term health. Researchers compare them with 10,000 siblings to see how treatments like radiation, chemotherapy, and surgery affect health …

This study talks to parents and teens with sickle cell disease to learn their thoughts on genetic research and gene therapy. Researchers will use surveys and interviews to understand concerns and expectations. The goal is to create a web tool that helps families and doctors discu…

This study is for children with blood cancer who are getting the seasonal flu vaccine. Researchers want to see how their immune system responds to the vaccine and how long that protection lasts. Up to 150 children will take part at St. Jude Children's Research Hospital. The goal …

This study looks at how a child's genes influence their response to medications for serious illnesses like cancer. Researchers will analyze DNA from up to 8,800 participants, including patients, their families, and volunteers. The goal is to understand why some children have diff…

This study collects blood, bone marrow, and other samples from people with non-cancerous blood diseases and their family members. Researchers will analyze the genetic information to find new genes linked to these conditions and understand why some people get sicker than others. T…

This study follows 184 people who survived medulloblastoma after receiving radiation therapy to the brain and spine. Researchers want to learn about long-term side effects like memory problems, hearing loss, heart and hormone issues, and physical fitness. The goal is to figure ou…

This study tests whether a communication skills training program designed for rehabilitation professionals (like physical and speech therapists) is practical and helpful. About 25 staff at St. Jude will take part, and researchers will measure how well the training works and how i…

This study looks at the long-term health and quality of life of children and young adults who received CAR T-cell therapy for B-cell acute lymphoblastic leukemia. Researchers will track participants for at least two years after treatment to understand late side effects, brain fun…

This study tests a new substance called [18F]-fluoromannitol, used in PET scans to help detect infections. Ten healthy adults will receive the tracer to see if it is safe and how it spreads in the body. The goal is to gather safety data so this tracer can later be used in people …

This study aims to learn more about the genetic and immune characteristics of several types of childhood solid tumors, including neuroblastoma and sarcomas. Researchers will collect tumor and blood samples from up to 1,000 children to analyze genes, proteins, and immune cells. Th…

This study follows up to 10,000 people with sickle cell disease over many years, collecting health data and blood samples during regular clinic visits. The goal is to learn how the disease damages organs over time and how treatments like hydroxyurea affect long-term health. Parti…

This study looks at the genetic information in tumor samples from children and teens diagnosed with melanoma or related skin growths. It does not provide any treatment—instead, it collects data to better understand these rare cancers. Up to 500 participants will have their stored…

This study looks at Hodgkin lymphoma survivors who had chest radiation and bleomycin treatment as children. Researchers want to see if these treatments affect brain blood flow and lung function during exercise. About 100 survivors and healthy volunteers will take part. The goal i…

This study tests a school readiness program for children aged 3.5 to 6.5 years with sickle cell disease. The goal is to see if the program is practical and helpful for improving learning skills. About 36 children and their caregivers will take part.

This study looks at whether sickle cell disease affects the ovaries of girls aged 10 to 18. Researchers will measure a hormone called AMH in blood samples and compare it to healthy girls of the same age and stage of puberty. They also want to see if pain crises or treatments for …

Childhood cancer survivors who had certain treatments are at higher risk for heart problems later in life. This study tests an online education program to encourage them to get a recommended heart screening test. Researchers will compare the program to standard care in 350 adult …

This study enrolls children aged 1 to 18 who are newly diagnosed with certain types of leukemia or lymphoma. Its main goal is to collect enough information about each child's cancer to determine their risk level and match them to the right treatment study. The study does not test…

This study watches how spinal muscular atrophy (SMA) drugs affect muscles and nerves in 24 children and teens aged 5 to 20 with SMA types 2 and 3. Researchers use MRI scans, blood tests, and muscle function tests to track changes over 12 months. The goal is to better understand h…

This study is creating a worldwide registry to collect medical information, family history, and tumor samples from children and teens with adrenocortical tumors. Researchers hope to better understand how these rare tumors develop, what treatments work best, and what role genetics…

This study looks at the reasons parents consider when deciding whether to enroll their child in a cancer clinical trial. Researchers will survey and interview 400 parents of children newly diagnosed with cancer. The goal is to learn how social factors and personal preferences aff…

This study tests a new way to help teens with serious cancer, their parents, and doctors have better conversations about what the future may hold. Researchers want to see if this personalized approach is practical and helpful for everyone involved. The goal is to improve how fami…

This study follows 100 children and young adults who received CAR T-cell therapy to learn about side effects like infections, slow blood cell recovery, and nerve problems. Researchers want to understand how often these issues happen and how long they last. The goal is to improve …

This study collects bone marrow that is normally thrown away during orthopedic surgery. Researchers will use these samples to learn how to better perform gene therapy and gene editing for blood disorders like sickle cell disease and thalassemia. Up to 50 participants of any age w…

This study talks to patients and parents of children with sickle cell disease to learn what they think and want to know about gene therapy. Researchers will use these insights to create an online tool that helps families make informed choices. No treatment is given—this is purely…

This study collects information directly from patients (ages 8 and up) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) about their symptoms and quality of life. Researchers will use surveys to track how patients feel over time and during treatment. The goal is to bui…

This study interviews patients, families, healthcare providers, and researchers to learn their views on the ethical challenges of small-scale, personalized treatments for rare neurological diseases. About 385 participants will share their opinions through interviews and surveys. …

This study looks at whether it's possible to regularly check for long-term health problems in people who survived high-risk neuroblastoma. Researchers will invite 45 survivors treated at St. Jude at least 2 years ago to undergo a series of health tests. The goal is to see if enou…