St. Jude Children's Research Hospital

This study tests whether a special type of immune cell, called B7-H3-CAR T cell, can help prevent bone cancer from coming back in children with high-risk osteosarcoma. About 41 children who have finished standard chemotherapy will receive these cells. The goal is to see if this a…

This study tests if shining a special light on the head (transcranial photobiomodulation) can improve thinking skills in children with sickle cell disease. The brain needs steady oxygen, which is often reduced in sickle cell disease, leading to learning problems. About 60 childre…

This study involves 100 children receiving proton therapy for solid tumors or Hodgkin lymphoma. During treatment, the body can change, affecting how well the radiation hits the tumor. Researchers will use weekly or bi-weekly CT and MRI scans to check if the treatment plan needs u…

This study looks at the short- and long-term side effects of asparaginase, a drug used to treat acute lymphoblastic leukemia and lymphoma in children. Researchers will track 200 participants to see how often serious side effects occur during standard treatment. The goal is to bet…

This study will take small liver samples from adults with hemophilia A or B who already received gene therapy. Researchers want to see how the gene therapy affected liver cells over time. The goal is to learn more about safety and long-term effects, not to provide a new treatment…

This study aims to understand why childhood cancer survivors often lose muscle mass and strength earlier than normal. Researchers will use advanced imaging and tests to compare muscle health in survivors and people without cancer. The goal is to find different types of muscle pro…