St. Jude Children's Research Hospital

This study tests a new nasal vaccine to prevent croup, a common childhood illness that can cause breathing problems. The vaccine uses a harmless virus (Sendai virus) that is similar to the croup virus. Researchers want to see if it is safe and helps children build immunity. About…

This study tests a personalized approach for children and young adults with medulloblastoma, a type of brain tumor. Treatment is customized based on the tumor's molecular subtype and how much cancer remains after surgery. The goal is to improve survival while reducing long-term s…

This study tests a combination of three drugs (ruxolitinib, dexamethasone, and etoposide) for hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The treatment is adjusted based on how well each patient responds. The trial includes up to 10 chil…

This study tests whether adding venetoclax to standard chemotherapy is safe and effective for children and young adults (up to age 22) with newly diagnosed acute myeloid leukemia (AML). The main goal is to see if the combination can clear even tiny amounts of cancer cells (called…

This study looks at a new way to treat craniopharyngioma, a rare brain tumor in children and young adults. Instead of removing the whole tumor, doctors do a smaller surgery and then use a precise type of radiation called proton therapy. The goal is to control the tumor while caus…

This study tests whether adding a targeted drug (brentuximab vedotin) to standard chemotherapy and radiation can better treat children and teens with high-risk Hodgkin lymphoma. About 77 participants with stage IIB, IIIB, or IV disease will receive the new combination. The goal i…

This study looks at whether a newer, more precise type of proton therapy can effectively treat craniopharyngioma, a rare brain tumor, while causing fewer side effects than older radiation methods. The trial includes children and young adults (ages 0-21) whose tumor was not comple…

This study tests a new way to do stem cell transplants for children and young adults with high-risk blood cancers like leukemia and lymphoma. Donor cells are treated in a lab to remove certain T cells that can cause a serious side effect called graft-versus-host disease. After th…

This study tests whether adding two adult cancer drugs, bortezomib and vorinostat, to standard chemotherapy can better treat infants with acute lymphoblastic leukemia (ALL). About 50 infants under one year old with newly diagnosed ALL will receive the combination. The goal is to …

This study tests an investigational drug called CPX-351 in 25 children and young adults (ages 1 to 21) who have developed a secondary blood cancer after previous cancer treatment. The goal is to see if the drug can put the cancer into remission so they can receive a stem cell tra…

This study tests a new treatment approach for patients with Ewing sarcoma or desmoplastic small round cell tumors, especially those at high risk of the cancer coming back. Participants are split into two groups: standard-risk patients get standard therapy, while high-risk patient…

This study tests a drug called alisertib in children and young adults under 22 with rare, aggressive tumors of the brain (AT/RT) or kidney (MRT). For those whose cancer has returned, alisertib is given alone. For newly diagnosed patients, it is combined with chemotherapy and some…

This study tests a new treatment called SJCAR19 for children and young adults up to age 21 whose leukemia has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to better find and kill cancer cells. The s…

This study tests a treatment plan for young children with certain brain tumors. The approach uses chemotherapy first to delay radiation, giving the brain more time to develop. Then, radiation is carefully aimed only at the tumor area to reduce learning and thinking problems. The …

This early-phase study tests a radioactive tracer called 18F-DA to see if it can create clearer PET scan images of neuroblastoma and pheochromocytoma tumors in children. The standard tracer often misses very small areas of disease. About 20 participants will receive the tracer an…

This study tests whether a combination of metformin (a diabetes drug) and a digital lifestyle program can safely prevent diabetes in adult survivors of childhood cancer who have prediabetes. About 96 participants will take part. The goal is to see if this approach is feasible and…

This study looks at whether a daily mindfulness app can help adult survivors of childhood cancer manage stress. About 50 survivors of leukemia or lymphoma will use the app for 30 days and wear a wrist device that tracks stress signs like heart rate and skin temperature. The goal …

This study tests a new approach to help childhood cancer survivors who struggle with memory, attention, and thinking speed. Participants use a special light device at home (called transcranial photobiomodulation) while doing computer-based brain training. The goal is to see if th…

This study follows 1,000 children with tumors who are receiving proton therapy as part of their regular care at St. Jude Children's Research Hospital. Researchers are not testing a new treatment but are carefully tracking serious side effects to better understand the safety of th…

This study looks at how children with cancer and their parents cope emotionally, focusing on both stress and positive growth. Researchers will compare their experiences to those of healthy children and their parents. The goal is to better understand what helps families thrive aft…

This study looks at how common obstructive sleep apnea (OSA) is in adult survivors of Hodgkin lymphoma who received chest radiation. Researchers will compare 220 survivors to a matched group of healthy people using sleep tests, brain scans, and neck muscle measurements. The goal …

This study looks at children with a type of cancer called mature B-cell lymphoma. The goal is to learn more about the tumor's biology and the long-term side effects of treatment. Researchers will analyze genes and other factors to improve future care. About 128 participants will …

This study follows over 1,500 young adult survivors of childhood cancers like leukemia, brain tumors, and Hodgkin lymphoma to measure frailty—a condition of increased vulnerability usually seen in older adults. Researchers aim to see how frailty changes over five years and whethe…

This study looks at whether a heart MRI can find hidden heart problems in children with cancer who have recently had sepsis. The goal is to better understand how sepsis affects the heart in these patients and help doctors decide on the best treatments. The study involves 7 partic…

This study asks childhood cancer survivors aged 18-39 to review and give feedback on exercise videos originally made for older adults. The goal is to make the videos more relatable and useful for young survivors. Ten participants will share their thoughts through interviews and a…

This study was designed to see if adult survivors of childhood cancer could use wearable devices and home tests to monitor their heart health remotely. It aimed to measure how many people would join and stick with the 12-week program. However, the study was withdrawn before any p…

This study gathers images from children receiving proton therapy for cancer to help doctors better understand and reduce positioning errors during treatment. By analyzing daily scans, researchers hope to make radiation more precise and safer. The study does not test a new treatme…

This study looks at whether adult survivors of childhood cancer are willing to take part in two behavioral programs at the same time. Participants will either do exercise plus cognitive training or exercise plus mindfulness practice for 12 weeks. The goal is to see how many peopl…

This study looks at how cancer affects the social experiences of teenagers and young adults, both during and after treatment. Researchers will interview about 121 participants aged 15-22 to understand their friendships, feelings of loneliness, and social support needs. The goal i…

This study looks at how having cancer as a young child (ages 4-6) affects their social development. Many children miss normal social activities like preschool and playgrounds. Researchers will follow 119 children who finished cancer treatment 6-12 months ago to see how their soci…

This study involves 837 adult survivors of childhood cancer. Researchers are developing and testing a questionnaire that lets survivors report their own symptoms, such as pain or fatigue, to help doctors better manage long-term side effects. The goal is to create a reliable tool …

This study looks at whether a special electronic pill bottle (AdhereTech) can accurately track how often teens with sickle cell disease take their medication, hydroxyurea. About 36 teens aged 12-17 will use the bottle for two months. The goal is to see if this device gives a bett…

This study looks at whether a special PET scan using a radioactive form of methionine (an amino acid) can help doctors see tumors in children and young adults with various cancers, including brain tumors and sarcomas. About 500 participants will be scanned to see how well the met…

This study looks at whether a new DNA-based test can predict bloodstream infections in children and teens with cancer who are at high risk. Current methods often detect infections too late, leading to serious illness or death. The researchers will compare the DNA test results wit…