St. Jude Children's Research Hospital

This study tests an experimental nasal vaccine made from a harmless virus (Sendai virus) that is similar to the one causing croup. The goal is to see if it is safe and helps children ages 1 to 5 build protection against croup. About 54 children will receive the vaccine as nose dr…

This study tests a gene therapy for infants with X-linked severe combined immunodeficiency (SCID-X1), a life-threatening condition where babies lack a working immune system. Researchers take the baby's own bone marrow stem cells, add a normal copy of the faulty gene using a lenti…

This study tests whether using a smaller radiation target area with proton therapy, after limited surgery, can control craniopharyngioma while reducing side effects in children and young adults. Some patients who had complete tumor removal are simply watched without radiation. Th…

This study tests different chemotherapy combinations based on a child's risk level for Hodgkin lymphoma. Low- and intermediate-risk patients receive a standard drug mix, while high-risk patients get a newer combination including brentuximab vedotin. The goal is to improve respons…

This clinical trial is testing whether adding two targeted drugs, venetoclax and navitoclax, to standard chemotherapy can help children whose acute lymphoblastic leukemia has returned or not responded to treatment. The study involves 35 participants and aims to find the best dose…

This phase 2 trial tests a personalized approach to treating medulloblastoma, a common childhood brain cancer. Instead of using a one-size-fits-all treatment, doctors assign therapy based on the tumor's molecular subtype (WNT, SHH, or other) and clinical risk (low to high). The g…

This study tests whether adding two adult cancer drugs, bortezomib and vorinostat, to standard chemotherapy is safe and effective for infants with acute lymphoblastic leukemia (ALL). About 50 newly diagnosed infants will receive the combination. The goal is to see if it reduces l…

This study tests a personalized approach for children aged 1-18 with newly diagnosed acute lymphoblastic leukemia or lymphoma. Using genetic information from each child's cancer, doctors add targeted drugs or immunotherapies to standard chemotherapy to improve cure rates and redu…

This study tests a drug called alisertib in children and young adults (up to age 22) with rare, aggressive tumors called atypical teratoid rhabdoid tumors (AT/RT) in the brain or malignant rhabdoid tumors (MRT) elsewhere in the body. For patients whose cancer has come back or not…

This phase 2 trial tests a shorter, intensive chemotherapy regimen (Stanford V) for children and young adults with favorable-risk Hodgkin lymphoma. Those who still have signs of cancer after 8 weeks of chemo also receive low-dose radiation to the affected areas. The goal is to se…

This clinical trial tests a risk-adapted approach for young children with newly diagnosed brain tumors. The treatment starts with chemotherapy to delay radiation, giving the brain more time to develop. Then, radiation is carefully targeted to the tumor area to reduce side effects…

This study tests a new treatment called SJCAR19 for children and young adults up to age 21 whose B-cell acute lymphoblastic leukemia (ALL) has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are collected, modified in a lab…

This study tests a treatment plan that adjusts medications based on how well a patient responds. It combines three drugs (ruxolitinib, dexamethasone, and etoposide) for children and young adults with a severe immune condition called HLH. The goal is to see if this approach is saf…

This study tests two drugs, selinexor and venetoclax, given together with standard chemotherapy for children and young adults whose acute myeloid leukemia (AML) has returned or not responded to treatment. The main goal is to find the safest dose and see how well the combination w…

This study tests whether giving a short course of DNA methylation drugs (azacitidine or decitabine) before standard chemotherapy is safe and can improve outcomes for children and young adults with newly diagnosed acute myeloid leukemia (AML). About 206 participants will receive o…

This study tests a personalized treatment plan for children with a rare muscle cancer called rhabdomyosarcoma. Depending on their risk level, patients receive a combination of proton beam radiation, surgery, and chemotherapy, with some getting extra maintenance therapy. The goal …

This study tests a new treatment for children and teens with high-risk Hodgkin lymphoma. It combines the targeted drug Adcetris with standard chemotherapy and, if needed, radiation. The goal is to see if this approach can shrink tumors faster and reduce the need for radiation the…

This study tests whether surgery followed by a second course of radiation can help children and young adults (ages 1-21) whose ependymoma has returned after initial treatment. The combined radiation dose is higher than standard. Researchers will track how long the tumor stays und…

This study tests whether adding the drug venetoclax to standard chemotherapy is safe and effective for children and young adults (up to age 22) with newly diagnosed acute myeloid leukemia (AML). The main goals are to see if the combination is tolerable and if it can clear tiny am…

This study tests a precise radiation technique called image-guided radiotherapy (IGRT) for children and young adults with bone or soft tissue tumors. By using CT, MRI, and PET scans to pinpoint the tumor, doctors aim to deliver radiation more accurately and reduce damage to healt…

This study tested a combination of two drugs, temozolomide and peginterferon, in children and young adults up to age 21 with advanced or recurrent melanoma that cannot be removed by surgery. The main goal was to see how well the tumors responded to treatment and to check for side…

This study is testing an investigational drug called CPX-351 in 25 people under age 22 who have secondary myeloid neoplasms (a type of blood cancer that develops after previous cancer treatment). The goal is to see if the drug can safely put the cancer into remission before a ste…

This study tests a newer form of proton therapy for people with craniopharyngioma, a rare brain tumor near the pituitary gland. The goal is to see if this precise radiation can control the tumor and cause fewer side effects than older radiation methods. The trial includes childre…

This study tests a new way to treat children and young adults with high-risk blood cancers like leukemia and lymphoma. Doctors take blood cells from a family donor, remove certain T cells that can cause a harmful immune reaction, and then transplant the modified cells. The goal i…

This study tests two short-term drug combinations (dasatinib plus quercetin, or fisetin alone) in 110 adult survivors of childhood cancer who are frail. The goal is to see if these treatments can improve walking speed and reduce markers of cell aging in the blood. The trial is a …

This study tests a new combination of drugs (temsirolimus, temozolomide, and irinotecan) for children and young adults with high-risk Ewing sarcoma or desmoplastic small round cell tumors. Participants are split into standard-risk and high-risk groups, with high-risk patients rec…

This study tests whether a special PET scan using a radioactive form of methionine (a natural amino acid) can help doctors see tumors in children and young adults with various cancers, including brain tumors and sarcomas. About 503 participants will be scanned to see if the metho…

This study tests a new radioactive tracer called 18F-DA for PET scans to see if it can find neuroblastoma and pheochromocytoma tumors more clearly than the current tracer. About 20 children and adults with known or suspected tumors will receive the tracer and be monitored for sid…

This study tests whether a combination of the diabetes drug metformin and a digital lifestyle program can safely prevent diabetes in adult survivors of childhood cancer who have prediabetes. About 96 participants will first try lifestyle changes alone for 12 weeks, then add metfo…

This study planned to see if wearing light therapy glasses could help reduce depression and tiredness in children and teens who had a stem cell transplant. Participants would have used the glasses for about four weeks while their mood and sleep were tracked. However, the study wa…

This study tests whether a special light therapy (transcranial photobiomodulation) used at home can help improve thinking and memory in adults who survived childhood leukemia or Hodgkin lymphoma. About 44 survivors will use a light device on their head while doing brain-training …

This study looks at how cancer treatment changes the social lives of adolescents and young adults aged 15 to 22. Researchers will survey patients on and off therapy about their friendships, loneliness, and family relationships. The goal is to understand their social needs and gui…

This study follows 1,000 children with cancer who are receiving proton therapy as part of their treatment at St. Jude Children's Research Hospital. The goal is to track and report any serious side effects caused by the radiation. This is not a treatment trial; instead, it observe…

This study looks at e-cigarette use among 500 teenage and young adult cancer survivors and tests a text-message based program to help them quit. Researchers will also interview patients and healthcare providers to find the best ways to offer this support in oncology clinics. The …

This study is developing a patient-reported survey to better capture symptoms in adults who survived childhood cancer. Researchers will work with 837 survivors to identify which symptoms matter most and create a validated tool. The goal is to improve long-term follow-up care by m…

This study looks at how cancer and its treatment affect social and emotional skills in children ages 4 to 6 who have finished therapy. Researchers will use questionnaires filled out by parents and the children themselves to track social thinking, play, and brain skills over time.…

This study looks at sleep problems in adults who had childhood cancer. About 200 survivors of leukemia, brain tumors, or solid tumors will fill out sleep surveys and wear a device to track their sleep at home. The goal is to find out how common sleep disorders are in this group.

This study looks at whether adult survivors of childhood cancer are willing to join two programs at once—exercise plus either brain training or mindfulness—over 12 weeks. The goal is to see if this combined approach is acceptable and can improve thinking and emotional well-being.…

This study looks at the biology of B-cell lymphoma in children and teens to better understand the disease and long-term effects of treatment. About 128 participants will provide tumor and blood samples for genetic analysis. The goal is not to test a new drug, but to gather knowle…

This study follows over 1,500 young adult survivors of childhood cancers like leukemia, brain tumors, and Hodgkin lymphoma to see how frailty (weakness, fatigue, low energy) develops over five years. Researchers want to find early signs of premature aging that can lead to serious…

This study is testing whether a new DNA-based test can predict bloodstream infections in children and young adults with cancer who are at high risk. The goal is to catch infections earlier, so doctors can treat them sooner and reduce the need for strong antibiotics. About 160 par…

This study aimed to see if adult survivors of childhood cancer could use wearable devices, surveys, and lab tests at home to monitor their heart health. It was designed for survivors who had certain cancer treatments. However, the study was withdrawn before enrolling any particip…

This study looks at whether a smartwatch ECG can predict heart muscle disease (cardiomyopathy) in adult survivors of childhood cancer as well as a standard clinic ECG does. About 1,300 survivors will have both a standard 12-lead ECG and a 30-second Apple Smartwatch ECG. The goal …

This study looks at whether a special electronic pill bottle (AdhereTech) can accurately track how often teens with sickle cell disease take their medication, hydroxyurea. About 36 teens aged 12 to 17 will use the bottle for two months. Researchers will compare the bottle's data …

This study looks at how children with cancer and their parents handle the emotional challenges of the disease. Instead of focusing only on negative effects like posttraumatic stress, researchers also explore positive changes, such as personal growth. The study compares these fami…

This study looks at whether people who survived Hodgkin lymphoma after chest radiation have a higher risk of obstructive sleep apnea (a condition where breathing stops during sleep). Researchers will compare 220 survivors to similar people without cancer. The goal is to find out …

This study looks at whether a daily mindfulness app can help adults who survived childhood leukemia or lymphoma handle stress better. About 50 participants will use the app for 30 days and wear a wrist device to track stress signs. The goal is to see if this approach is practical…

This study gathers imaging data from 367 children receiving proton therapy for cancer. Researchers will analyze daily scans to understand how patient positioning and movement affect treatment accuracy. The goal is to improve future radiation therapy by identifying factors that ca…

This study uses special PET scans to measure inflammation in the brain after radiation therapy in children with medulloblastoma. About 22 participants will be scanned multiple times over two years to see how inflammation changes. The goal is to better understand radiation's effec…

This study looks at whether it's possible to screen for long-term health problems in people who survived high-risk neuroblastoma. Researchers will evaluate survivors who finished treatment at least 2 years ago, using tests for heart, nerve, and other health issues. The goal is to…

This study asks childhood cancer survivors aged 18-39 who are not very active to review exercise videos and share their thoughts. The goal is to make the videos more relatable and useful for survivors. Researchers will use interviews and a questionnaire to understand what works b…

This study aimed to use wearable fitness trackers to measure heart rate and sleep patterns in adult survivors of childhood cancer. The goal was to understand how common heart-related nerve problems are in this group compared to their siblings. However, the study was withdrawn bef…

This study looks at whether data from smartphones and wearable devices can help predict future health problems in adults who survived childhood cancer. About 600 survivors will track symptoms, activity, sleep, and heart rate. The goal is to use this information to improve follow-…