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Precision proton beam takes aim at childhood brain tumors

NCT ID NCT02792582

Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a newer form of radiation called intensity-modulated proton therapy in children and young adults with craniopharyngioma, a rare brain tumor. The goal is to see if this precise radiation can better control the tumor while causing fewer side effects than older radiation methods. The trial includes 160 participants who either receive proton therapy after incomplete surgery or are simply observed after complete tumor removal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Proton therapy (a precise form of radiation)
What this could lead to
If successful, this could offer a more effective and less harmful radiation treatment for children with this rare brain tumor, potentially improving survival and quality of life.
What could go wrong
This is a phase II trial, so results are still preliminary. The therapy may not work better than standard radiation, and there are still risks of side effects from radiation exposure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

160 people

The number who actually took part.

Started

Jun 2016

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Up to 21 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Craniopharyngioma diagnosed by histology, cytology or neuroimaging or intra-operative assessment * Patients ages 0-21 years at the time of diagnosis Exclusion Criteria: * Prior history of fractionated radiation therapy * Prior treatment with intracystic P-32 or intracystic bleomycin * Pregnant females are excluded. Radiation has teratogenic or abortifacient effects

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Conditions

The condition(s) this trial relates to.

brain cancer craniopharyngioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Craniopharyngioma

Contacts and locations

Locations

  • St. Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.