New drug combo offers hope for kids with relapsed leukemia
NCT ID NCT04898894
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 25 times
Summary
This early-phase trial tests the safety and best dose of two drugs, selinexor and venetoclax, when added to standard chemotherapy for children and young adults whose acute myeloid leukemia (AML) has returned or not responded to treatment. The study involves 37 participants and aims to find a dose that is both safe and effective. While not a cure, the goal is to better control the disease and improve remission rates.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Childrens Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Memorial Sloan-Kettering Cancer Center
New York, New York, 10065, United States
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Rady Children's Hospital-San Diego
San Diego, California, 92123, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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UT Southwestern/Simmons Cancer Center
Dallas, Texas, 75390, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
Conditions
Explore the condition pages connected to this study.