New drug combo offers hope for kids with tough leukemia
NCT ID NCT04898894
First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 23 times
Summary
This early-stage study tests the safety and best dose of two drugs, selinexor and venetoclax, when given with standard chemotherapy to children and young adults whose acute myeloid leukemia (AML) has returned or not responded to treatment. About 37 participants will receive the combination to see if it can help achieve remission. The goal is to find a tolerable dose and measure how well the treatment works.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Childrens Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Memorial Sloan-Kettering Cancer Center
New York, New York, 10065, United States
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Rady Children's Hospital-San Diego
San Diego, California, 92123, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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UT Southwestern/Simmons Cancer Center
Dallas, Texas, 75390, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
Conditions
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