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Hidden sleep danger for hodgkin survivors: study investigates

NCT ID NCT03361020

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study examines how common obstructive sleep apnea (OSA) is in adult survivors of Hodgkin lymphoma who received chest radiation. Researchers will compare 220 survivors to matched controls using sleep tests, brain scans, and heart assessments. The goal is to understand links between sleep apnea, heart problems, and brain health in this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better screen for and manage sleep apnea in Hodgkin lymphoma survivors, potentially reducing heart and brain complications.
What could go wrong
This is an observational study, not a treatment trial. It will not test any new therapy, and results may not apply to all survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

434 people

The number who actually took part.

Started

Jan 2018

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be survivors of Hodgkin Lymphoma (HL) who were treated with thoracic radiation during the course of their HL, who meet eligibility criteria, and who consent to this study. The Comparison or control group members will be recruited from healthy parents, sibling, relative or friends who accompany the participant for follow-up at SJCRH and who meet eligibility criteria.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

HODGKIN LYMPHOMA SURVIVOR ELIGIBILITY CRITERIA Inclusion Criteria (Hodgkin Lymphoma Survivor): * Current participant in the SJLIFE clinical trial ongoing at St. Jude Children's Research Hospital (SJCRH) and was treated with thoracic radiation for Hodgkin lymphoma * Currently ≥ 18 years of age * ≥ 5 years from original diagnosis Exclusion Criteria (Hodgkin Lymphoma Survivor): * History of cranial or total-body radiation therapy * History of intrathecal Methotrexate, high-dose Methotrexate, or high-dose Cytarabine. * History of head injury or diagnosis of a genetic disorder associated with neurocognitive impairment * History of a neurodevelopmental disorder or birth complication associated with neurocognitive impairment * History of congenital heart disease reported in the literature to be associated with neurocognitive status as determined by the PIs * Currently pregnant * Secondary central nervous system (CNS) neoplasm COMPARISON GROUP (CONTROL) ELIGIBILITY CRITERIA Inclusion Criteria (Comparison Group): * Research participant is a sibling, parent, relative or friend of a current or former St. Jude patient * Research participant must be at least 18 years of age at the time of the scheduled evaluation Exclusion Criteria (Comparison Group): * History of cranial, total-body or thoracic radiation therapy * History of intrathecal Methotrexate, high-dose Methotrexate, or high-dose Cytarabine. * History of head injury or diagnosis of a genetic disorder associated with neurocognitive impairment * History of a neurodevelopmental disorder or birth complication associated with neurocognitive impairment * History of congenital heart disease reported in the literature to be associated with neurocognitive status as determined by the PIs * Currently pregnant * History of cancer * 1st degree relative of a survivor included in the current study.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • St. Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

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