Hidden sleep danger for hodgkin survivors: study investigates
NCT ID NCT03361020
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study examines how common obstructive sleep apnea (OSA) is in adult survivors of Hodgkin lymphoma who received chest radiation. Researchers will compare 220 survivors to matched controls using sleep tests, brain scans, and heart assessments. The goal is to understand links between sleep apnea, heart problems, and brain health in this high-risk group.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors better screen for and manage sleep apnea in Hodgkin lymphoma survivors, potentially reducing heart and brain complications.
- What could go wrong
- This is an observational study, not a treatment trial. It will not test any new therapy, and results may not apply to all survivors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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434 people
The number who actually took part.
- Started
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Jan 2018
- Expected to finish
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Jul 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants will be survivors of Hodgkin Lymphoma (HL) who were treated with thoracic radiation during the course of their HL, who meet eligibility criteria, and who consent to this study. The Comparison or control group members will be recruited from healthy parents, sibling, relative or friends who accompany the participant for follow-up at SJCRH and who meet eligibility criteria.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
HODGKIN LYMPHOMA SURVIVOR ELIGIBILITY CRITERIA Inclusion Criteria (Hodgkin Lymphoma Survivor): * Current participant in the SJLIFE clinical trial ongoing at St. Jude Children's Research Hospital (SJCRH) and was treated with thoracic radiation for Hodgkin lymphoma * Currently ≥ 18 years of age * ≥ 5 years from original diagnosis Exclusion Criteria (Hodgkin Lymphoma Survivor): * History of cranial or total-body radiation therapy * History of intrathecal Methotrexate, high-dose Methotrexate, or high-dose Cytarabine. * History of head injury or diagnosis of a genetic disorder associated with neurocognitive impairment * History of a neurodevelopmental disorder or birth complication associated with neurocognitive impairment * History of congenital heart disease reported in the literature to be associated with neurocognitive status as determined by the PIs * Currently pregnant * Secondary central nervous system (CNS) neoplasm COMPARISON GROUP (CONTROL) ELIGIBILITY CRITERIA Inclusion Criteria (Comparison Group): * Research participant is a sibling, parent, relative or friend of a current or former St. Jude patient * Research participant must be at least 18 years of age at the time of the scheduled evaluation Exclusion Criteria (Comparison Group): * History of cranial, total-body or thoracic radiation therapy * History of intrathecal Methotrexate, high-dose Methotrexate, or high-dose Cytarabine. * History of head injury or diagnosis of a genetic disorder associated with neurocognitive impairment * History of a neurodevelopmental disorder or birth complication associated with neurocognitive impairment * History of congenital heart disease reported in the literature to be associated with neurocognitive status as determined by the PIs * Currently pregnant * History of cancer * 1st degree relative of a survivor included in the current study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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