St. Jude Children's Research Hospital

This study is testing a new type of CAR T-cell therapy for children and young adults (up to age 21) whose blood cancers have come back or haven't responded to standard treatments. The main goal is to find the safest and most effective dose of these specially engineered immune cel…

This study is testing a new drug called mirdametinib for children and young adults with low-grade glioma, a type of brain tumor. The goal is to find the safest and most effective dose and to see if the drug can shrink or control the tumor. The drug is designed to reach the brain …

This study is testing whether special infection-fighting cells from a donor can safely treat stubborn cytomegalovirus (CMV) and adenovirus infections in patients who have had a bone marrow transplant. Researchers will collect these virus-specific immune cells from a partially mat…

This study tests whether a specialized form of radiation called proton therapy can be precisely aimed to avoid damaging memory centers in the brain while treating low-grade brain tumors in children and young adults. Researchers want to see if this 'hippocampal avoidance' techniqu…

This study is testing a new type of immunotherapy for children and young adults (up to age 21) whose solid tumors have come back or haven't responded to standard treatments. Doctors take a patient's own immune cells (T cells), modify them in a lab to better target a protein calle…

This study is testing how well the drug entrectinib works as the first treatment for children under 3 years old who have brain tumors with specific genetic changes (NTRK or ROS1 fusions). The goal is to see if the drug shrinks the tumors and helps children live longer without the…

This study is testing whether a new drug called CM4620 can safely reduce the severity of a serious pancreas inflammation (acute pancreatitis) that sometimes occurs in children and young adults receiving a specific chemotherapy drug (asparaginase) for leukemia. Researchers will gi…

This study is testing a treatment called CAR T-cell therapy for children and young adults (up to age 21) whose CD19-positive leukemia has come back or hasn't responded to other treatments. Doctors collect a patient's own immune cells, modify them in a lab to better target cancer,…

This study is testing a new type of treatment called CD123-CAR T-cell therapy for children and young adults (up to age 21) whose blood cancers have come back or haven't responded to other treatments. Doctors take a patient's own immune cells, modify them in a lab to better target…

This study is testing whether adding an experimental immune-boosting drug called N-803 to a standard chemoimmunotherapy regimen works better for treating neuroblastoma that has returned or is not responding to prior therapy. It will involve about 54 children and young adults unde…

This is a first-in-human study to test the safety and find the right dose of a new type of CAR T-cell therapy for children and young adults (up to age 21) whose CD19-positive leukemia has come back or hasn't responded to other treatments. The therapy uses immune cells (T-cells) f…

This early-stage trial is testing the safety of a new combination treatment for children and young adults (up to age 21) whose bone or soft tissue cancers (sarcomas) have come back or haven't responded to standard treatments. The approach combines a short, intense course of radia…

This early-stage study is checking if a fecal microbiota transplant (FMT) is safe and practical for children who develop severe gut problems after a lifesaving bone marrow transplant. The procedure transfers healthy gut bacteria from a screened donor to try to restore normal dige…

This early-stage trial is testing the safety of a new type of blood cell transplant for children and young adults (up to age 21) with high-risk blood cancers. The treatment uses specially processed cells from a partially matched family donor, followed by an infusion of immune cel…

This early-stage study is testing if a drug called motixafortide is safe for adults with severe sickle cell disease. Researchers want to see if the drug helps the body release more stem cells into the bloodstream so they can be collected. These collected cells could potentially b…

This study is testing a new two-step treatment for children and young adults with a specific type of leukemia or lymphoma that has come back or hasn't responded to other treatments. First, patients receive a stem cell transplant from a partially matched family donor. Then, they r…

This early-stage study is testing the safety of a new type of CAR T-cell therapy for children and young adults (up to age 21) whose acute lymphoblastic leukemia has come back or hasn't responded to other treatments. The therapy uses the patient's own modified immune cells designe…

This trial is testing whether adding two targeted immunotherapies, inotuzumab and blinatumomab, to standard chemotherapy can better control leukemia in children and young adults. It aims to see if this combination helps more patients achieve deep remission with minimal detectable…

This study is testing a combination of chemotherapy drugs (ifosfamide, doxorubicin), a targeted drug (pazopanib), and sometimes a newer drug (selinexor) and radiation therapy for young patients (up to age 30) with rare soft tissue cancers. The goal is to see if this approach can …

This study is testing personalized chemotherapy plans for children under 5 years old who have a type of brain cancer called medulloblastoma. Doctors will assign different treatment combinations based on the child's specific tumor type and age, aiming to control the cancer while t…

This study aims to help young cancer survivors quit vaping by understanding their habits and testing a phone app support program. Researchers will work with 500 survivors aged 13-24 to learn about their vaping behaviors and interest in quitting. They will then develop and test th…

This study is testing a more targeted form of radiation called proton beam therapy for children with a kidney cancer called Wilms tumor. The main goal is to see if using protons on a smaller area can control the cancer just as well as standard radiation while allowing the child's…

This study is testing whether adding a new drug called revumenib to two standard chemotherapy drugs is safe and effective for children and young adults with acute myeloid leukemia (AML) that has come back or hasn't responded to previous treatment. The main goal is to find the saf…

This study is testing a new combination of four medicines for children and young adults (under 30) whose solid tumors have come back or haven't responded to standard treatments. The first part checks if the drug mix is safe and finds the right dose. The second part sees how well …

This early-stage study is testing a new type of personalized immune therapy called B7-H3-CAR T cells for children and young adults (up to age 21) with brain tumors that have come back or haven't responded to standard treatments. The therapy involves collecting a patient's own imm…

This early-stage study is testing the safety of a new gene editing treatment for severe sickle cell disease. Researchers will collect a patient's own blood stem cells, edit them in the lab using CRISPR technology to boost protective fetal hemoglobin, and then infuse them back. Th…

This study is testing whether adding one of two targeted drugs, dasatinib or venetoclax, to standard chemotherapy can help children and young adults with newly diagnosed T-cell leukemia or lymphoma. The goal is to see if these additions lead to better early results and improve su…

This study is testing two different drug combinations to find safe doses and see if they can help control cancer in children and young adults whose solid tumors have come back or haven't responded to treatment. In the first part, participants will be assigned to receive either On…

This study is testing if a wrist-worn sensor and a symptom questionnaire can accurately detect heart nerve problems in childhood cancer survivors from their homes. Researchers want to see if these remote methods work as well as a longer, in-person clinic test. If successful, this…

This study is testing whether a special fluorescent dye can help surgeons see and remove pediatric solid tumors more completely during surgery. Children and teens with solid tumors who need surgery will receive an injection of the dye, which makes tumors glow under a special came…

This study is testing if a special dye called Indocyanine Green (ICG) is safe and useful for helping surgeons see and remove lymph nodes during cancer surgery in children. The dye is injected during the operation to make the lymph nodes that drain from the tumor easier to identif…

This program offers a special type of PET scan to children and young adults with known or suspected cancers in the brain, spine, or head/neck area. The scan uses a small, safe amount of a radioactive tracer that may help doctors see the cancer more clearly. The goal is to provide…

This study is testing an online educational program designed to encourage adult survivors of childhood cancer to get a recommended heart screening test. Survivors who had certain cancer treatments are at higher risk for future heart problems. Researchers want to see if interactiv…

This study is testing whether a long-acting antibiotic called dalbavancin, given every 28 days, can prevent serious bloodstream infections in children and young adults with high-risk leukemia who are receiving intense chemotherapy. The trial will enroll up to 29 participants to s…

This study is testing whether using virtual reality (VR) for brain training exercises is practical and helpful for children and young adults (ages 8-22) who are getting radiation treatment for brain tumors. Researchers will compare VR-based training to training on an iPad to see …

This study is testing if a daily ADHD medication called methylphenidate is safe and practical for children with sickle cell disease who have trouble with focus, memory, and schoolwork. Over 4 weeks, 30 children will take the medication once a day to see if they can stick with it …

This study is testing whether a creative writing activity can help teenagers and young adults with cancer. Researchers want to see if patients are willing to participate and find it helpful. Participants will write about their cancer experiences with optional guidance from a writ…

This study is testing whether a simple, non-invasive earbud device can help adult survivors of childhood leukemia who struggle with insomnia. The device gently stimulates a nerve in the ear. Researchers will see if using it nightly improves sleep quality, reduces stress, and help…

This study is testing whether adding virtual reality (VR) to standard pain treatment helps children and young adults with sickle cell disease during painful crises. Participants receive either standard care alone or standard care plus a 15-minute VR session designed to distract f…

This study is testing a virtual summer program designed to help preschool children with sickle cell disease get ready for school. Researchers want to see if an 8-week online program for parents and children improves school readiness skills like early math, reading, and self-contr…

This study is testing if a special cooling cap can safely prevent hair loss in children and young adults receiving chemotherapy. It aims to see if kids can comfortably wear the cap during treatment and if it helps them keep their hair. The goal is to improve quality of life by re…

This study is testing whether a specially adapted phone app that teaches pain management skills is more helpful than standard pain education for reducing chronic pain in teen survivors of childhood cancer. It will involve 204 participants (teens and their caregivers) across four …

This study aims to understand the factors that influence parents' decisions about enrolling their children in cancer treatment trials. Researchers will survey and interview 400 parents of newly diagnosed pediatric cancer patients to learn about their experiences, concerns, and de…

This study aims to understand how young adults with an inherited higher risk of cancer manage their health care after they graduate from their pediatric hospital. Researchers will follow 56 participants for up to 8 years to see if they successfully find adult doctors and continue…

This study aims to understand the long-term health effects of childhood cancer treatments like chemotherapy and radiation. Researchers are following 50,000 survivors and 10,000 of their siblings to track health outcomes over decades. The goal is to identify risks for heart proble…

This study aims to collect blood, saliva, and health information from people with blood diseases and their family members to build a research library. The goal is to discover unknown genetic causes and understand why disease severity varies between people. This is a research-only…

This is a long-term observational study that will follow 10,000 people with sickle cell disease from birth through their entire lives. The goal is to collect detailed health information over time to understand how the disease progresses, how it damages organs, and how treatments …

This study aims to understand how a child's unique genetic makeup influences how their body processes and responds to medications, especially those used to treat cancer and other catastrophic illnesses. Researchers at St. Jude Children's Research Hospital will collect genetic inf…

This study aims to create a long-term health database for 10,000 adults who survived childhood cancer. Researchers will track participants over their lifetime to understand the long-term health effects of childhood cancer treatments. The goal is to identify risks and develop bett…

This study is testing a new way to help teenagers and young adults with serious cancer, and their parents, have better conversations with their doctors about the future. It involves a 'communication preferences companion' who helps families figure out how they want to discuss pro…

This study aims to understand if sickle cell disease affects ovarian health in young females. Researchers will compare hormone levels in 440 girls with sickle cell to healthy peers of the same age and puberty stage. The goal is to learn how the disease and its treatments might in…

This study aims to understand how parents communicate with their children and young adults about inherited genetic risks for cancer. Researchers will observe family conversations and conduct interviews to identify what helps or hinders these important discussions. The goal is to …

This study aims to learn how existing spinal muscular atrophy (SMA) medications affect patients' muscles and nerve cells over time. Researchers will observe 24 children and young adults (ages 5-20) with SMA types 2 and 3 who are already taking drugs like Spinraza, Zolgensma, or E…

This study aims to learn more about melanoma in children and adolescents by analyzing leftover tumor tissue and blood samples. Researchers will look for genetic changes in the cancer cells to understand how these tumors develop and respond to treatment. The study does not test ne…

This study aims to understand how young adult survivors of childhood leukemia feel about exercise. Researchers will test 125 inactive survivors using computer tasks and questionnaires before and after physical activity. The goal is to learn about emotional barriers to exercise an…

This study follows childhood medulloblastoma survivors to understand the long-term health effects of their cancer treatments. Researchers will monitor 184 survivors who received radiation therapy at least five years ago, checking for issues like thinking problems, hearing loss, a…

This study aims to understand the perspectives of patients, families, and medical professionals on the ethical challenges of creating personalized treatments for rare and severe childhood neurological disorders. Researchers will conduct interviews and surveys with about 385 parti…

This study aims to understand how past Hodgkin lymphoma treatments affect brain and heart function long-term. Researchers will compare 100 survivors who received specific treatments with healthy volunteers, measuring brain blood flow and heart/lung performance during exercise. Th…

This study aims to understand why survivors of childhood acute lymphoblastic leukemia (ALL) often experience muscle weakness. Researchers will compare 60 survivors with healthy volunteers using MRI scans, blood tests, and muscle biopsies to examine how cancer treatment affects mu…

This study aims to learn about the long-term side effects of CAR-T cell therapy in children and young adults with cancer. Researchers will follow 100 participants for up to two years to track how often they get serious infections, have slow blood count recovery, or experience las…

This study aims to understand how sleep and breathing problems might affect brain function, mood, and pain in teenagers with sickle cell disease. Researchers will mail sleep-monitoring devices to 65 participants (ages 12-18) to use at home for three nights. Later, participants wi…

This study aims to understand the long-term health of children and young adults who survived high-risk neuroblastoma after receiving modern treatments. Researchers will check participants' heart, nerve, and organ function to see if any late health problems develop. The goal is to…

This study collects long-term health information from childhood cancer survivors treated at St. Jude Children's Research Hospital. It aims to understand the late effects of cancer treatments by tracking 30,000 survivors for at least 10 years after their diagnosis. The goal is to …

This study aims to discover new genes that cause cancer to run in families, especially those affecting children. Researchers will collect health information, blood, and sometimes leftover tumor samples from families where multiple members have had cancer. The goal is to build a l…

This study aims to understand the long-term health of young people who survived B-cell acute lymphoblastic leukemia (B-ALL) after receiving CAR T-cell therapy. Researchers will follow 80 survivors who are at least two years past their treatment to check for any late-developing he…

This study aims to understand how common sleep problems are among adults who survived childhood cancer. Researchers will measure sleep patterns, fatigue, and thinking skills in 120 survivors using at-home sleep monitors and questionnaires. The goal is to identify connections betw…

This study aims to understand why people with sickle cell disease often develop heart problems. Researchers will compare how blood flows to the heart during stress in three groups: young adults with sickle cell and heart stiffness, those with sickle cell without stiffness, and he…

This is a very early safety study for a new substance used in PET scans, a type of medical imaging. Researchers are testing it in 10 healthy adults to see how it moves through the body and to check for any side effects. The goal is to gather basic safety information so that in th…

This study aims to deeply understand the genetic and molecular changes that occur in several aggressive childhood solid tumors, including neuroblastoma and osteosarcoma. Researchers will collect tumor samples from up to 1,000 patients to analyze their DNA, RNA, and cell structure…

This study is creating a worldwide registry to gather information about a very rare childhood cancer called adrenocortical tumor. Researchers will collect medical and family history from patients under 21, their parents, and relatives to better understand this disease's patterns,…

This study aims to understand how well the seasonal flu vaccine protects children being treated for blood cancers like leukemia. Researchers will follow 150 young patients for a year, taking small blood samples to measure their immune response after vaccination. The goal is to se…

This study aims to learn more about how COVID-19 affects children and young adults, particularly those with cancer. Researchers will collect samples from participants who have tested positive for the virus to understand their symptoms, how their immune system responds, and how lo…

This study aims to understand how children with advanced cancer and their parents experience hope while participating in early-stage treatment trials. Researchers will ask 100 participants to share photos and stories about their hopes over time. The goal is to use these insights …

This study aims to understand the genetic causes of childhood cancers by analyzing the complete DNA (genome) of 2500 children with tumors. Researchers will compare DNA from a child's tumor with their normal DNA to find inherited and tumor-specific changes. The goal is to gather k…

This study aims to collect bone marrow samples that are normally thrown away during orthopedic surgery. Researchers will use these samples to learn how to better use gene therapy and gene editing techniques to treat serious inherited blood disorders like sickle cell disease and t…

This study aims to create and test two simple questionnaires. The goal is to better identify and measure the feelings of stigma experienced by children with cancer and their parents or caregivers. Researchers will work with families in the United States, Guatemala, and Jordan to …

This study aims to understand the attitudes and concerns of parents and adolescents with sickle cell disease regarding genetic research and clinical trials. Researchers will conduct interviews and surveys with families to learn about their knowledge, trust in healthcare providers…

This study aims to understand what patients and families think and need to know when considering gene therapy for rare diseases like sickle cell. Researchers will interview patients, parents, and healthcare workers about their experiences and concerns. Using what they learn, the …

This study aims to collect the detailed information doctors need to choose the most appropriate treatment plan for children newly diagnosed with certain types of acute leukemia. Children aged 1-18 will receive 7 days of initial chemotherapy while their cancer cells are tested. Th…