St. Jude Children's Research Hospital
Clinical trials sponsored by St. Jude Children's Research Hospital, explained in plain language.
Upcoming readouts
Trials from this sponsor expected to report results within the next 12 months.
- Scientists dive deep into DNA of Kids' cancers to unlock secrets Results expected Sep 2026 (estimated)
- New hope for kids with blood cancer: tailored treatments aim to boost cure rates and cut side effects Results expected Sep 2026 (estimated)
- New hope for kids with relapsed leukemia: experimental drug combo enters safety trial Results expected Oct 2026 (estimated)
- Can a summer program help kids with sickle cell disease thrive in school? Results expected Oct 2026 (estimated)
- Can VR goggles tame sickle cell pain? new trial aims to find out Results expected Nov 2026 (estimated)
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Can a Weight-Loss pill help young cancer survivors?
Disease control Not yet recruitingThis trial tests whether a weight-loss medication called phentermine/topiramate, combined with healthy lifestyle counseling, can safely reduce obesity in adolescents and young adults who have survived leukemia or lymphoma. Participants are randomly assigned to receive either the …
Phase 2 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Can a simple screening test at birth save thousands of children with sickle cell disease?
Diagnosis Not yet recruitingThis study tests whether combining point-of-care screening with community-based strategies can help identify infants with sickle cell disease early and connect them to care. Researchers will screen up to 6,750 newborns in Mozambique and track their health outcomes. The goal is to…
Sponsor: St. Jude Children's Research Hospital • Aim: Diagnosis
Last updated Jul 24, 2026 00:00 UTC
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Scientists to examine liver tissue after gene therapy for hemophilia
Knowledge-focused Not yet recruitingThis observational study will take small liver samples from 8 adults with hemophilia A or B who had gene therapy at least 6 months ago. Researchers want to see how the gene therapy affected liver cells, including how many cells still carry the therapy and whether there is any liv…
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Sep 19, 2026 00:00 UTC
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New study tracks hidden dangers of common leukemia drug
Knowledge-focused Not yet recruitingThis study will follow 200 children with acute lymphoblastic leukemia or lymphoma to learn more about the short- and long-term side effects of asparaginase drugs. Researchers will track how often serious toxicities occur during standard treatment and a newer therapy called SJALL2…
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Sep 19, 2026 00:00 UTC
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Can a light cap boost brain power in kids with sickle cell?
Knowledge-focused Not yet recruitingThis study tests whether shining a special light on the head (transcranial photobiomodulation) can improve oxygen use and thinking skills in children with sickle cell disease. The brain needs steady oxygen, but sickle cell can reduce blood flow. Researchers will randomly assign 6…
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Childhood cancer Survivors' hearts under the microscope
Knowledge-focused Not yet recruitingThis study will use heart scans and blood tests to check for early signs of heart disease in 650 adult survivors of childhood cancer. The goal is to better understand who is at highest risk due to past cancer treatments like radiation or chemotherapy. Results will be compared to …
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Sep 06, 2026 00:00 UTC
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Can a new PET tracer reveal the Body's hidden stress?
Knowledge-focused Not yet recruitingThis first-in-human study tests the safety of a new PET imaging tracer called [18F]fluoroedaravone in healthy adults. Participants receive one injection of the tracer and undergo several PET/CT scans over about three hours. Researchers collect blood and urine samples, check vital…
Early phase 1 • Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Sep 05, 2026 00:00 UTC
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Stem cell harvest trial aims to unlock gene therapy for rare blood disorders
Knowledge-focused Not yet recruitingThis early-phase study at St. Jude Children's Research Hospital will test whether it is safe and possible to collect blood stem cells from 12 young adults with inherited bone marrow failure syndromes. Participants will receive two drugs (filgrastim and plerixafor) to move stem ce…
Phase 1 • Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC