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Engineered immune cells take aim at childhood cancers

NCT ID NCT04897321

First seen Nov 01, 2025 · Last updated Jun 18, 2026 · Updated 30 times

Summary

This early-stage trial tests a new immunotherapy for children and young adults up to age 21 with solid tumors that have come back or not responded to standard treatment. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein called B7-H3 found on many solid tumors. The main goal is to find the safest dose and see if the treatment can shrink tumors.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • St. Jude Children's Research Hospital

    RECRUITING

    Memphis, Tennessee, 38105, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

adrenal cortex carcinoma adrenal cortex neoplasm carcinoma childhood neoplasm clear cell sarcoma desmoplastic small round cell tumor Ewing sarcoma germ cell tumor hepatoblastoma malignant peripheral nerve sheath tumor melanoma Neoplasms, Germ Cell and Embryonal neuroblastoma neurofibrosarcoma osteosarcoma rhabdoid tumor rhabdomyosarcoma sarcoma soft tissue sarcoma Wilms tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.