SOFT TISSUE SARCOMA

This early-phase trial tests a custom-made RNA vaccine designed to help the immune system recognize and attack tumors in people with advanced melanoma or soft tissue sarcoma whose cancer has worsened despite standard immunotherapy. Up to 18 adults will receive three doses of the …

This phase 3 trial tests whether adding ADI-PEG 20 to standard chemotherapy (gemcitabine and docetaxel) can help people with advanced leiomyosarcoma that has already been treated. About 300 participants will receive either the study drug or a placebo, plus chemo. The main goal is…

This study tests two chemotherapy drugs, trabectedin and gemcitabine, in 100 people with advanced leiomyosarcoma that has spread or cannot be removed. Participants have already tried one prior treatment. The goal is to see which drug better delays tumor growth. The study also inc…

This study tests an experimental drug called MT-4561 in people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have tried at least one prior therapy. The main goals are to find a safe dose and check for early signs of tumor shrinkage. About 27 adults will…

This study tests a drug called tigilanol tiglate, which is injected directly into tumors, for people with advanced or metastatic soft tissue sarcoma that has spread to the arms, legs, or body wall. About 40 adults will receive the treatment to see if it can shrink or destroy the …

This study tests whether adding 4 cycles of chemotherapy around the time of surgery can help prevent the spread of soft tissue sarcoma in people whose tumors are considered high-risk based on a genetic test. About 600 adults with resectable sarcoma will be screened, and 250 high-…

This study tests a new drug called envafolimab, given as a shot under the skin, combined with standard chemotherapy (doxorubicin and ifosfamide) for people with advanced soft tissue sarcoma who haven't had treatment before. The goal is to see if the combo works better than chemo …

This study tests a daily pill called AL3818 (anlotinib) for people with a rare cancer called alveolar soft part sarcoma (ASPS) that has spread. The goal is to see if the drug can shrink tumors or slow the cancer. About 325 adults with ASPS are being enrolled. Participants take th…

This study tests whether a shorter course (2-3 weeks) of proton or carbon ion radiation before surgery for soft tissue sarcoma is safe and reduces wound healing problems compared to the standard 5-week treatment. About 42 adults with resectable sarcoma in an arm or leg will parti…

This study tests a non-invasive treatment called high intensity focused ultrasound (HIFU) for soft tissue sarcoma and small desmoid tumors. HIFU uses sound waves to destroy tumor cells without surgery or needles, with the goal of fewer side effects and faster recovery. About 10 t…

This study tests whether a special vacuum dressing placed on the surgical wound can reduce complications like infection and slow healing after lower-limb sarcoma surgery. About 291 adults who had radiation before surgery will be randomly assigned to get either the vacuum dressing…

This early-phase study tests a technique called in vivo lung perfusion (IVLP) that delivers chemotherapy directly into the lung during surgery to remove sarcoma tumors that have spread to the lungs. The goal is to kill any microscopic cancer cells left behind, which standard surg…

This early-stage trial tests a new drug, AVA6000, designed to deliver chemotherapy directly to tumor cells while reducing harm to healthy tissue. It is for people with advanced solid tumors (like breast, ovarian, or salivary gland cancer) that have not responded to standard treat…

This early-phase study tests a new treatment called DIT309, which uses a patient's own immune cells engineered to fight cancer. It is for people with advanced bone or soft tissue sarcoma who have not responded to standard treatments. The main goals are to check safety, find the b…

This study tests whether a 5-day course of radiation before surgery is safe and effective for adults with soft tissue sarcoma. Standard radiation takes 25 days. The goal is to see if the shorter course leads to fewer complications while still controlling the cancer. About 75 part…

This study tests a shorter, 5-day radiation treatment before surgery for soft tissue sarcoma in the arms or legs. The goal is to protect healthy tissue while still treating the cancer and preventing its spread. About 40 adults will take part to see if this approach is safe and ef…

This study tests whether two drugs, zanzalintinib and pembrolizumab, can help control advanced or metastatic soft-tissue sarcoma. About 20 adults with specific sarcoma types will receive the combination. The main goal is to check safety and side effects.

This early-stage study is testing whether a new type of immune cell therapy, called HER2-CAR T cells, combined with drugs that boost the immune system (pembrolizumab or nivolumab), is safe for people with advanced sarcoma. About 25 participants will receive chemotherapy before th…

This early-stage trial tests a personalized cell therapy for children and young adults (up to age 21) with solid tumors that have come back or not responded to standard treatment. Doctors take the patient's own immune cells, modify them to recognize a protein called B7-H3 on tumo…

This early-stage study tests a new drug (177Lu-DFC413) that delivers radiation directly to cancer cells in adults with advanced solid tumors, including pancreatic, lung, breast, colorectal, and soft tissue cancers. The main goals are to check safety, find the right dose, and see …

This study tests whether adding an experimental immune-boosting drug (retifanlimab) to standard chemotherapy (gemcitabine and docetaxel) can help control advanced soft tissue sarcoma that has spread or cannot be removed by surgery. About 98 adults with this rare cancer will recei…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control tumors for at least 12 months. About 28 adults who have not responded to standard treatments will take part.

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy, radiation, and surgery can delay the return of high-risk soft tissue sarcoma in the arms, legs, or trunk. About 50 adults with certain aggressive sarcoma types will receive atezolizumab …

This study is testing a new way of giving radiation before surgery for a rare type of cancer called retroperitoneal sarcoma. The goal is to see if this approach is safe and reduces complications during and after surgery. About 50 adults with this cancer will receive focused radia…

This study tests whether combining two drugs—cadonilimab and anlotinib—can help people with advanced or metastatic soft tissue sarcoma whose cancer worsened after standard first-line therapy. The trial enrolls 27 adults with various sarcoma subtypes. The main goal is to see how l…

This study compares a shorter, higher-dose radiation schedule (hypofractionated) to the standard longer schedule before surgery for soft tissue sarcoma. The goal is to see if the shorter approach is safe and effective at killing tumor cells. 30 adults with sarcoma in an arm, leg,…

This study tests if a short course of proton therapy (5 sessions) before surgery for soft tissue sarcoma in the arms, legs, or trunk is safe and effective. About 40 adults will receive the therapy and then have standard surgery. Researchers will track wound healing problems and q…

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if their tumors shrink or stop growing for at least 24 weeks. The goal is to fi…

This early-phase trial tests a new treatment called attIL12 T-cell therapy for people with advanced soft tissue or bone sarcoma that has spread. The therapy uses the patient's own immune cells, modified to attack the cancer. The main goal is to find a safe dose and see if it can …

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This study tests whether the immunotherapy drug dostarlimab works better than standard chemotherapy as the first treatment for people with advanced cancers that have specific genetic markers (dMMR/MSI). The cancers studied are rare types like pancreatic, stomach, and small bowel …

This study is testing whether a special type of PET/CT scan, using a radioactive tracer called 68Ga-DOTATATE, can produce clearer images of soft tissue sarcomas. The goal is to see if this scan can help doctors decide if a patient might benefit from a specific type of radiation t…

This study tests whether a dye injected during surgery can help doctors see if any cancer cells remain after removing a sarcoma. About 50 adults with bone or soft tissue sarcoma will take part. The dye's accuracy will be compared to standard lab results.

This study looks at whether offering mental healthcare early during sarcoma treatment can help reduce depression and anxiety and improve quality of life. About 60 adults with bone or soft tissue sarcoma who are scheduled for surgery will take part. Researchers will check how many…

This study looks at whether a pre-treatment exercise program can improve arm or leg function and reduce wound problems in people with soft tissue sarcoma. About 24 adults who will receive radiation therapy followed by surgery are being recruited. Researchers will track wound comp…

This study tests if a personalized exercise program before surgery helps people with soft tissue sarcoma recover faster and with less disability. About 30 adults will either follow the exercise plan during standard radiotherapy or receive usual care. The goal is to see if pre-sur…

This study is for people with aggressive soft-tissue sarcoma (grade 2 or 3, larger than 5 cm). Researchers want to see if special MRI scans and blood tests can predict whether the cancer will spread to other parts of the body. The goal is to find better ways to personalize treatm…

This study looks at how people who had limb-saving surgery for sarcoma (a rare cancer) in their leg move and feel in daily life. Researchers will measure walking patterns, physical function, and quality of life in 60 adults who are at least one year past surgery. The goal is to l…

This early study is testing whether contrast-enhanced ultrasound (CEUS) can help doctors see how soft tissue sarcomas respond to radiation therapy before surgery. Ten adults scheduled for radiation will get three CEUS scans to measure tumor blood flow and pressure. The goal is to…

This study looks at how removing soft tissue sarcoma from the arms or legs affects a person's body image, quality of life, and physical abilities like walking and joint movement. Researchers will ask 150 patients who had surgery between 2010 and 2021 to fill out questionnaires an…

This study aims to learn more about the immune system's role in rare types of sarcoma, a group of cancers. Researchers will collect medical information and tissue samples from 500 patients with these rare sarcomas. The goal is to find patterns that could lead to better treatments…