WILMS TUMOR

This early-stage trial tests a new treatment for children and young adults with solid tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The m…

This study tests whether a precise type of radiation called proton beam can treat Wilms tumor while causing less damage to healthy growing tissues. About 260 children with newly diagnosed Wilms tumor who need abdominal radiation will take part. The goal is to see if this approach…

This study tests a drug called tegavivint in children, teens, and young adults (ages 1 to 30) whose solid tumors have returned or not responded to standard therapy. The drug works by blocking a key signal that tells cancer cells to grow. The trial aims to find the safest dose, un…

This study tests a mix of four drugs (vorinostat, vincristine, irinotecan, and temozolomide) in children, teens, and young adults up to age 30 whose solid tumors or brain cancers have returned or not responded to standard treatment. The main goal is to find the safest dose of vor…

This study tests a drug called selinexor in children and young adults whose Wilms tumor, rhabdoid tumor, or other solid tumors have come back or not responded to treatment. The goal is to see if the drug can shrink tumors. About 45 participants will take selinexor pills, and doct…

This early-phase trial tests a new type of immunotherapy for adults with solid tumors that have a protein called GPC3 on their surface. Researchers take a patient's own T cells, add genes to help them recognize and attack GPC3-positive cancer cells, and also include a safety swit…

This early-stage trial tests a new treatment using the body's own immune cells (T cells) that are specially trained to attack cancer. It is for children with certain cancers (rhabdomyosarcoma, Ewing sarcoma, neuroblastoma, or Wilms tumor) that have come back or not responded to s…

This early-phase trial tests a new treatment called CARE T cells for children whose solid tumors (like liver cancer or Wilms tumor) have returned or not responded to standard care. The treatment involves taking a patient's own immune cells, adding special genes to help them recog…

This early-stage trial tests a personalized cell therapy for children and young adults (up to age 21) with solid tumors that have come back or not responded to standard treatment. Doctors take the patient's own immune cells, modify them to recognize a protein called B7-H3 on tumo…

This study tests a special low-dose chemotherapy schedule (metronomic chemo) in children aged 1.5 to 17 years whose Wilms tumor has come back or not responded to standard treatments. The goal is to see if this approach can stop the tumor from growing after two treatment cycles. A…

This study tests a new drug called Becotatug Vedotin in children aged 2 to 18 with certain cancers (like head and neck, brain, or kidney tumors) that have come back or spread. The drug targets a protein called EGFR found on many cancer cells. The main goal is to see if the drug i…

This study is testing a precise type of radiation called proton therapy for children and young adults with kidney tumors like Wilms tumor. The goal is to see if it causes fewer short-term side effects than standard radiation. About 28 people under 30 who need radiation as part of…