EWING SARCOMA

This early-phase study tests an experimental oral drug called ST-01156 in people with advanced solid tumors (including Ewing sarcoma, liver cancer, and bile duct cancer) that have not responded to standard treatments. The drug works by breaking down a protein (RBM39) that cancer …

This study tests a mix of four drugs (vorinostat, vincristine, irinotecan, and temozolomide) in children, teens, and young adults up to age 30 whose solid tumors or brain cancers have returned or not responded to standard treatment. The main goal is to find the safest dose of vor…

This early-phase study tests a new drug called INBRX-109 in people with advanced solid tumors, including Ewing sarcoma and colorectal cancer. The drug is a lab-made antibody designed to target and kill cancer cells. The main goals are to check safety and see if tumors shrink. Abo…

This early-phase study tests whether a new treatment combining radiation and specially engineered immune cells (B7-H3-CAR T cells) is safe for children and young adults up to age 21 with sarcomas that have come back or not responded to standard therapy. About 42 participants will…

This study tests a combination of two drugs, pembrolizumab and cabozantinib, in people with advanced sarcomas that have not responded to standard treatments. The goal is to see if this combo can stop or shrink tumors for at least 6 months. About 119 adults with specific sarcoma t…

This study tests a stem cell transplant that removes certain immune cells (alpha/beta T cells and CD19+ B cells) and adds a drug called zoledronic acid to help the donor cells fight solid tumors that have come back or not responded to treatment. It includes children and young adu…

This early-stage trial tests a new treatment using the body's own immune cells (T cells) that are specially trained to attack cancer. It is for children with certain cancers (rhabdomyosarcoma, Ewing sarcoma, neuroblastoma, or Wilms tumor) that have come back or not responded to s…

This study is for children, teens, and young adults (up to age 39) with sarcoma that has spread to a few other places in the body. The goal is to see if giving radiation to those spread spots, along with standard treatment, can help them live longer without the cancer getting wor…

This study is for people with bone sarcomas who have finished their first round of treatment. It tests whether taking the drug regorafenib for up to 12 months can help keep the cancer from returning, compared to just being watched. About 168 participants will be randomly assigned…

This study tests a new way of giving radiation therapy for Ewing sarcoma, a type of bone or soft tissue cancer. The radiation dose is tailored to each patient's tumor size and features, with higher doses given over a shorter time. The goal is to better control the tumor at its or…

This early-stage trial tests an experimental drug called xaluritamig in about 50 people (adults, teens, and children) whose Ewing sarcoma has returned or stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers will…

This study tests a drug called lurbinectedin in children and young adults (ages 2 to 30) with solid tumors, especially Ewing sarcoma that has returned or not responded to prior treatment. The first part finds the safest dose; the second part checks if the drug shrinks tumors. Abo…

This early-phase trial is testing whether combining two drugs, cabozantinib and high-dose ifosfamide, is safe and effective for people with sarcomas (a type of cancer) that have returned or not improved after standard treatment. The study includes both children and adults. The ma…

This study tests a new oral drug, AMXT 1501, combined with another drug called DFMO for children and young adults (up to age 21) with certain cancers like neuroblastoma, brain tumors, and sarcomas. The first part finds the safest dose, and the second part checks if the combo help…

This early-stage study tests a new type of stem cell transplant for children whose blood cancer or solid tumor has returned or is hard to treat. Doctors use a special method to remove certain immune cells from the donor's stem cells, then give a drug called zoledronate after tran…

This early-stage study is testing whether a new type of immune cell therapy, called HER2-CAR T cells, combined with drugs that boost the immune system (pembrolizumab or nivolumab), is safe for people with advanced sarcoma. About 25 participants will receive chemotherapy before th…

This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma or sarcoma) have come back or not responded to treatment. The goal is to find a safe dose and see if the c…

This early-stage trial tests a personalized cell therapy for children and young adults (up to age 21) with solid tumors that have come back or not responded to standard treatment. Doctors take the patient's own immune cells, modify them to recognize a protein called B7-H3 on tumo…

This study tests a new drug called zilovertamab vedotin in children and young adults (up to age 30) whose blood cancers or solid tumors have come back or not responded to treatment. The goal is to see if the drug is safe and can shrink or control the cancer. About 90 participants…

This early-stage study tests a new drug, DXC008, for safety and the right dose in people with prostate cancer or other solid tumors like Ewing sarcoma. About 110 adults who have not responded to standard treatments will take part. The goal is to see if the drug is safe and to get…

This study is testing a drug called lurbinectedin in people aged 10 and older whose solid tumors (like Ewing sarcoma) have come back or not responded to standard treatment. The goal is to see if the drug is safe and can shrink tumors or delay their growth. Participants must have …

This study looks at how well people with bone cancer follow a personalized home exercise program after having surgery to remove a tumor from their leg. About 50 patients will track their daily exercises for six months. The goal is to understand what helps or hinders them from sti…

This study looks at children with neuroblastoma or Ewing sarcoma who had ovarian or testicular tissue frozen to preserve their fertility before cancer treatment. The problem is that this tissue might contain hidden cancer cells that could cause the cancer to return if the tissue …