EWING SARCOMA

This early-phase study tests an experimental drug called CLR 131 in children, adolescents, and young adults (ages up to 30) with certain cancers that have come back or not responded to standard treatments. The cancers include solid tumors (like neuroblastoma and sarcomas), lympho…

This early-stage study tests whether a treatment made from a patient's own tumor-fighting immune cells (TIL) is safe for children, teenagers, and young adults with solid tumors that have come back or stopped responding to standard treatments. About 40 participants will receive th…

This early-phase study tests a new treatment for children and young adults (up to age 26) with solid tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein c…

This study tests a daily pill called cabozantinib in children and young adults (up to age 30) with rare cancers like sarcomas, Wilms tumor, and others that have come back or not responded to treatment. The drug works by blocking signals that help tumors grow and form blood vessel…

This early-stage study tests a flavored, drinkable chemotherapy called VAL-413 (Orotecan) for children and young adults (ages 1-30) whose solid tumors have come back. The drug is given by mouth along with another chemo, temozolomide, for 5 days. The main goal is to find the safes…

This early-phase study tests a personalized cell therapy for children and young adults (ages 1–30) whose solid tumors have come back or not responded to standard treatment. Researchers take a patient's own immune T cells, modify them to recognize and attack cancer cells that carr…

This early-phase trial tests whether adding the targeted drug regorafenib to standard chemotherapy is safe for people with newly diagnosed, widespread Ewing sarcoma. The study enrolls about 23 patients aged 2 to 49 whose cancer has spread beyond the lungs. The goal is to find a s…

This study looks at whether a special PET scan using a natural amino acid called methionine can help doctors see tumors in children and young adults with cancer. About 500 participants will get the scan to check if it can find tumors at diagnosis and tell the difference between a…

This study looks at whether a blood test (liquid biopsy) can help predict how well children and young adults with Ewing sarcoma or osteosarcoma will do. Researchers will check for tumor DNA in the blood at diagnosis and see if it relates to cancer returning. The goal is to better…