OSTEOSARCOMA

This study tests whether the drug regorafenib, taken for up to 12 months, can help control high-grade bone sarcomas (a type of bone cancer) in patients whose tumors did not fully disappear after standard treatments. About 36 participants aged 12 and older will receive regorafenib…

This early-phase study tests a new treatment called DIT309, which uses a patient's own immune cells engineered to fight cancer. It is for people with advanced bone or soft tissue sarcoma who have not responded to standard treatments. The main goals are to check safety, find the b…

This early-phase trial tests a combination of two drugs, losartan and sunitinib, in people aged 10 and older with osteosarcoma (a type of bone cancer) that has returned or stopped responding to standard treatments. The main goals are to find the safest dose and check for early si…

This study tests a new treatment called afamitresgene autoleucel in children and young adults aged 2 to 21 with certain advanced cancers (synovial sarcoma, MPNST, neuroblastoma, or osteosarcoma). The treatment uses the patient's own immune cells, which are modified in a lab to be…

This study tests a combination of two drugs, pembrolizumab and cabozantinib, in people with advanced sarcomas that have not responded to standard treatments. The goal is to see if this combo can stop or shrink tumors for at least 6 months. About 119 adults with specific sarcoma t…

This study compares two surgical methods to remove osteosarcoma that has spread to the lungs: open surgery (one large cut) and keyhole surgery (several small cuts with a camera). About 62 people under age 50 with up to 4 lung nodules will take part. The goal is to see which appro…

This early-phase study tests a new treatment called B7-H3 CAR T cells in children and young adults whose solid tumors (like neuroblastoma, sarcoma, or osteosarcoma) have come back or not responded to standard therapies. The treatment involves taking a patient's own immune cells, …

This study tests a combination of two drugs—apatinib and liposomal irinotecan—in people with advanced osteosarcoma (bone cancer) that has spread or come back after standard treatments. The goal is to find the safest and most effective dose and see if the combo can shrink tumors o…

This early-phase study tests a new treatment called PeptiCRAd-1, a virus designed to train the immune system to attack cancer cells, combined with the immunotherapy drug pembrolizumab. About 15 adults with certain advanced solid tumors (like melanoma, lung cancer, or sarcoma) wil…

This study tests a stem cell transplant that removes certain immune cells (alpha/beta T cells and CD19+ B cells) and adds a drug called zoledronic acid to help the donor cells fight solid tumors that have come back or not responded to treatment. It includes children and young adu…

This study is for people with bone sarcomas who have finished their first round of treatment. It tests whether taking the drug regorafenib for up to 12 months can help keep the cancer from returning, compared to just being watched. About 168 participants will be randomly assigned…

This early-phase study is for people whose osteosarcoma has come back in the lungs. It combines an immunotherapy drug (atezolizumab) with precise radiation and surgery to remove tumors. The main goal is to see if this approach is safe and tolerable, with a secondary focus on cont…

This early-phase study tests a new treatment for children whose neuroblastoma or osteosarcoma has returned or not responded to standard therapy. The treatment uses the patient's own T-cells, which are modified in a lab to better recognize and attack cancer cells. The main goals a…

This early-phase trial is testing whether combining two drugs, cabozantinib and high-dose ifosfamide, is safe and effective for people with sarcomas (a type of cancer) that have returned or not improved after standard treatment. The study includes both children and adults. The ma…

This study looks at whether a drug called dexrazoxane can help prevent heart problems in children and teens who have been treated for certain cancers like leukemia or lymphoma. Researchers will check blood samples and heart scans from about 420 survivors to see how well the drug …

This study tests a new oral drug, AMXT 1501, combined with another drug called DFMO for children and young adults (up to age 21) with certain cancers like neuroblastoma, brain tumors, and sarcomas. The first part finds the safest dose, and the second part checks if the combo help…

This early-stage study tests a new type of stem cell transplant for children whose blood cancer or solid tumor has returned or is hard to treat. Doctors use a special method to remove certain immune cells from the donor's stem cells, then give a drug called zoledronate after tran…

This study tests a new drug called PEEL-224 combined with two standard chemotherapy drugs (vincristine and temozolomide) in adolescents and young adults whose sarcomas have returned or not responded to prior treatment. The goal is to find the safest dose and see if the combinatio…

This early-stage study is testing whether a new type of immune cell therapy, called HER2-CAR T cells, combined with drugs that boost the immune system (pembrolizumab or nivolumab), is safe for people with advanced sarcoma. About 25 participants will receive chemotherapy before th…

This study tests an experimental pill called silmitasertib combined with standard chemotherapy in children and young adults (under 30) whose solid tumors (like neuroblastoma or sarcoma) have come back or not responded to treatment. The goal is to find a safe dose and see if the c…

This early-stage trial tests a personalized cell therapy for children and young adults (up to age 21) with solid tumors that have come back or not responded to standard treatment. Doctors take the patient's own immune cells, modify them to recognize a protein called B7-H3 on tumo…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control tumors for at least 12 months. About 28 adults who have not responded to standard treatments will take part.

This study is for people with solid tumors (like lung, ovarian, or pancreatic cancer) that have stopped responding to standard treatments. It tests a new drug called AOH1996, which works by blocking certain enzymes that cancer cells need to grow. The main goals are to find the be…

This program provides access to an experimental drug called L-MTP-PE for people with osteosarcoma, a type of bone cancer. The drug works by activating white blood cells to help the immune system kill cancer cells. It is available to patients of any age who have had surgery to rem…

This study tests whether adding four drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy helps people with osteosarcoma that has spread live longer. About 45 participants with newly diagnosed or advanced disease will be enrolled. Researchers will als…

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This study follows 300 people who had surgery to remove bone tumors and then had reconstruction using bone grafts or artificial parts. Researchers will measure how well the bone heals and how much function returns over 3 years. The goal is to learn more about recovery after these…

This study follows 150 people whose high-grade osteosarcoma returned near the original tumor site. Researchers will look at medical records to find factors that affect how long patients live after the cancer comes back. The goal is to learn more about the disease, not to test a n…

This study looks at how well people with bone cancer follow a personalized home exercise program after having surgery to remove a tumor from their leg. About 50 patients will track their daily exercises for six months. The goal is to understand what helps or hinders them from sti…

This study looks at different types of scans (MRI, PET/MR, and PET/CT) to see which one works best for finding tumors in children and young adults. About 100 participants with solid tumors or suspected tumors will be enrolled. The goal is to compare how well each scan detects tum…

This pilot study looks at 10 people with a new diagnosis of high-grade osteosarcoma in an arm or leg. The goal is to see if removing the tumor with surgery before starting chemotherapy leads to better movement and quality of life. Participants and their surgeons will fill out que…

This early-phase study tests whether a new radioactive tracer can help doctors see tumors on PET/CT scans. About 32 adults with different solid tumors will receive a single injection of the tracer. The goal is to understand where the tracer goes in the body, how it is cleared, an…

This study explores whether growing a patient's tumor cells in the lab (as organoids) can help doctors predict which chemotherapy drugs will work best for that individual. Researchers will collect tissue from biopsies or surgeries of 40 people with suspected or confirmed osteosar…

This study looks at whether using 3D printed models of a patient's bones helps surgeons plan and perform tumor removal surgery. About 150 people with bone tumors will be randomly assigned to have their surgeon use either 3D models plus regular scans, or just scans alone. The main…

This study tests whether a smartwatch can track changes in walking and daily activities in 60 people with bone cancer (osteosarcoma or metastatic bone disease) in the legs or pelvis. Participants wear the watch at least 12 hours a day and complete weekly questionnaires for 12 wee…