CARCINOMA

This study tests the drug vorolanib in people with advanced kidney cancer that cannot be removed by surgery or has spread. It is for patients who need a second treatment after the first one stopped working. The goal is to see how long the drug controls the cancer and what side ef…

This study tests a precise type of radiation called carbon ion radiotherapy for people with liver cancer that still has active tumors after a prior treatment called TARE. The goal is to see if this approach can safely shrink or control those remaining tumors. About 48 adults with…

This study tests whether a blood test that detects HPV DNA can help doctors tailor the intensity of chemotherapy and radiation after surgery for HPV-positive throat cancer. About 50 participants will receive treatment based on their blood test results and standard risk factors. T…

This study tests an experimental oral drug (NRC-2694-A) combined with a standard chemotherapy (paclitaxel) in people with advanced head and neck cancer that has returned or spread and no longer responds to immunotherapy. About 46 adults will receive the combination to see if it c…

This study is for people with advanced liver cancer that cannot be removed by surgery. It combines a precise type of radiation (carbon ion radiotherapy) with two standard drugs (atezolizumab and bevacizumab) to see if the radiation helps control the tumor better. About 52 adults …

This early-stage trial tests a personalized cell therapy for children and young adults (up to age 21) with solid tumors that have come back or not responded to standard treatment. Doctors take the patient's own immune cells, modify them to recognize a protein called B7-H3 on tumo…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women whose gynecologic carcinosarcoma has returned after at least one prior chemotherapy. The goal is to see if the combination can keep the cancer from growing for at least 6 months. Participants w…

This early-stage study tests a new PET imaging agent, 18F-Clofarabine, to measure an enzyme (DCK) activity in metastatic cancers. The goal is to see if this scan can predict whether drugs like gemcitabine will be taken up by cancer cells. About 4 adults with metastatic cancer wil…

This study is testing whether an artificial intelligence tool can help match cancer patients to clinical trials they might be eligible for. Researchers will enroll up to 50,000 people with various types of cancer and use the AI to suggest trials. The goal is to see if this approa…

This study is a large registry that will follow about 2,000 people in Germany with advanced ovarian or endometrial cancer. Researchers will collect information on treatments, side effects, and quality of life over time. The goal is to understand what really happens in everyday me…

This study is testing a French version of a questionnaire called the Nasal Reconstruction FACE-Q. It is for people who had surgery to rebuild their nose after skin cancer. The goal is to see if the questionnaire reliably measures how patients feel about their appearance, quality …

This study looks at whether a blood test that detects tiny bits of tumor DNA can help monitor kidney cancer after surgery. Researchers will follow 450 people with newly diagnosed kidney cancer who have surgery to remove the tumor. The goal is to see if this test can predict cance…

This study is creating a large collection of tumor samples and medical information from 1,500 people with pancreatic cancer. The goal is to provide resources for future research, not to test a new treatment. Participants will donate tissue and data during their standard care.