CARCINOMA

This early-phase study tests a new way to deliver chemotherapy directly into the abdomen for people whose appendix or colon cancer has spread to the lining of the belly. After surgery to remove visible tumors, participants receive a combination of drugs: one given through a port …

This program gives adults with advanced or spreading ROS1-positive non-small cell lung cancer access to taletrectinib when they cannot use approved treatments or join ongoing studies. It is for patients who, in their doctor's opinion, might benefit from the drug. The goal is to p…

This study tests whether adding savolitinib to osimertinib can help people with a specific type of advanced lung cancer (EGFR-mutated, MET-positive) whose cancer has worsened despite osimertinib treatment. About 345 adults will be randomly assigned to receive either the drug comb…

This early-phase study tests a new treatment for children and young adults (up to age 26) with solid tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein c…

This early-phase study tests a personalized cell therapy for children and young adults (ages 1–30) whose solid tumors have come back or not responded to standard treatment. Researchers take a patient's own immune T cells, modify them to recognize and attack cancer cells that carr…

This study tests whether adding a second drug (savolitinib) to the standard drug osimertinib can shrink tumors in people with a specific type of advanced lung cancer (EGFR-mutant, MET-positive) that has stopped responding to osimertinib alone. About 367 adults whose cancer worsen…

This study tests a new drug, savolitinib, against a standard treatment, sunitinib, for people with a specific type of advanced kidney cancer called MET-driven papillary renal cell carcinoma. The goal is to see if savolitinib works better at slowing cancer growth and to check its …

This study tests a computer program that analyzes colonoscopy images to help doctors decide if a growth (polyp) is likely cancerous (adenoma) or not. About 1,178 adults with confirmed polyps will have their images reviewed by the software. The goal is to see if the AI can accurat…

This study looks at whether a urine test called BladMetrix can reliably detect bladder cancer recurrence in 500 adults with non-muscle invasive bladder cancer. Participants provide extra urine samples during routine follow-up visits over two years. The goal is to see if this test…

This study compares two treatments for early-stage oropharyngeal (throat) cancer: robotic surgery or radiation therapy. The goal is to see which approach leads to better swallowing function and overall quality of life. About 138 patients will be randomly assigned to one of the tw…

This study tests a pre-surgical toolkit (OPTI-Surg) designed to help older cancer patients recover faster and better after major surgery. The toolkit provides recommendations before surgery to improve physical function and reduce complications. About 325 participants with planned…

This study collects blood and urine samples from 1,000 adults who are getting radiation therapy for cancer. Researchers want to see how radiation changes genes in white blood cells, damages red blood cells, and alters hormone levels. Samples are taken before, during, and after tr…