New hope for rare kidney cancer: targeted drug shows promise in Late-Stage trial

NCT ID NCT03091192

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 24 times

Summary

This study tests a new drug called savolitinib against a standard treatment (sunitinib) in people with a rare type of kidney cancer (papillary renal cell carcinoma) that has spread and cannot be removed by surgery. The cancer must have a specific genetic change (MET-driven). The goal is to see if savolitinib works better at stopping the cancer from growing and to check its side effects. About 60 adults are taking part in this advanced-stage trial.

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Contacts and locations

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Locations

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La Jolla, California, 92093, United States
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Atlanta, Georgia, 30322, United States
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Chicago, Illinois, 60637, United States
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Iowa City, Iowa, 52242, United States
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Boston, Massachusetts, 02215, United States
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Kansas City, Missouri, 64132, United States
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New York, New York, 10021, United States
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Nashville, Tennessee, 37203, United States
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Barretos, 14784-400, Brazil
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Curitiba, 81520-060, Brazil
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Passo Fundo, 99010-080, Brazil
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Pelotas, 096015-280, Brazil
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Porto Alegre, 90050-170, Brazil
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Porto Alegre, 90610-000, Brazil
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Porto Alegre, 91350-200, Brazil
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Rio de Janeiro, 22793-080, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01323-903, Brazil
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Bordeaux, 33000, France
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Vandœuvre-lès-Nancy, 54519, France
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Villejuif, 94805, France
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Arezzo, 52100, Italy
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Meldola, 47014, Italy
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Milan, 20133, Italy
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Modena, 41100, Italy
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Orbassano, 10043, Italy
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Pavia, 27100, Italy
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Roma, 00152, Italy
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Krasnoyarsk, 660133, Russia
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Moscow, 105077, Russia
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Moscow, 115478, Russia
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Moscow, 115522, Russia
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Moscow, RU-121356, Russia
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Murmansk, 183047, Russia
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Nizhny Novgorod, 603109, Russia
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Obninsk, 249036, Russia
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Omsk, 644013, Russia
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Saint Petersburg, 194017, Russia
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Saint Petersburg, 195271, Russia
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Saint Petersburg, 196603, Russia
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Volgograd, 400138, Russia
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Daejeon, 35015, South Korea
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Goyang-si, 10408, South Korea
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Hwasun-gun, 58128, South Korea
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Incheon, 21565, South Korea
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Seoul, 03080, South Korea
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Seoul, 05505, South Korea
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Seoul, 06273, South Korea
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Seoul, 120-752, South Korea
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Seoul, 6351, South Korea
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Dnipro, 49005, Ukraine
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Dnipro, 49102, Ukraine
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Ivano-Frankivsk, 76018, Ukraine
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Kharkiv Region, 61070, Ukraine
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Kyiv, 03022, Ukraine
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Kyiv, 03115, Ukraine
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Odesa, 65055, Ukraine
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Sumy, 40022, Ukraine

Conditions

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CARCINOMA CARCINOMA, RENAL CELL ENZYME INHIBITORS KIDNEY DISEASES KIDNEY NEOPLASMS NEOPLASMS BY SITE NEOPLASMS BY SITE PROTEIN KINASE INHIBITORS UROLOGIC NEOPLASMS UROLOGIC NEOPLASMS