New hope for tough childhood cancers: targeted drug combo under study
NCT ID NCT01946529
First seen Nov 01, 2025 · Last updated Jun 02, 2026 · Updated 35 times
Summary
This study tests a new combination of drugs (temsirolimus, temozolomide, and irinotecan) for children and young adults with high-risk Ewing sarcoma or desmoplastic small round cell tumors. Participants are split into standard-risk and high-risk groups, with high-risk patients receiving the experimental therapy first. The goal is to see if this approach shrinks tumors and improves long-term survival, with follow-up lasting 10 years.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.