Hope for infants with leukemia: new drug combo trial launches
NCT ID NCT02553460
First seen Jan 09, 2026 · Last updated Jun 22, 2026 · Updated 30 times
Summary
This study tests whether adding two adult cancer drugs, bortezomib and vorinostat, to standard chemotherapy is safe and effective for infants with acute lymphoblastic leukemia (ALL). About 50 newly diagnosed infants will receive the combination. The goal is to see if it reduces leukemia cells and improves survival, while monitoring side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Alberta Children's Hospital
Calgary, Alberta, T3A 6A8, Canada
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Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, H3T 1C5 CAN, Canada
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Centre Hospitalier Universitaire de Quebec
Québec, Quebec, G1V 4G2, Canada
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Children's & Women's Health Centre of British Columbia
Vancouver, British Columbia, V6H 3V4, Canada
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital and Clinics of Minnesota
Minneapolis, Minnesota, 55404, United States
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Children's Hospital of Orange County
Orange, California, 92868, United States
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Children's Hospital of the King's Daughters (CHKD)
Norfolk, Virginia, 23507, United States
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Cincinnati Children's Hospital
Cincinnati, Ohio, 45229, United States
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Lucile Packard Children's Hospital Stanford University
Palo Alto, California, 94304, United States
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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St. Jude Affiliate-Charlotte
Charlotte, North Carolina, 28204, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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Stollery Children's Hospital
Edmonton, Alberta, T6G 2B7, Canada
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The Montreal Children's Hospital (MUHC-McGill)
Montreal, Quebec, H4A 3J1, Canada
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bortezomib and vorinostat (cancer drugs) added to standard chemotherapy
What this could lead to
If it works, this could lead to a more effective treatment for infant leukemia, potentially improving survival rates.
What could go wrong
This is an early-phase trial with only 50 infants, so results are uncertain. The added drugs may cause severe side effects or not improve outcomes.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.