New stem cell trick may help kids fight tough cancers
NCT ID NCT01625351
First seen Feb 06, 2026 · Last updated Jun 23, 2026 · Updated 20 times
Summary
This early-phase study tested a new way to do stem cell transplants in 23 children whose solid tumors or lymphomas had come back. The method uses a special filter to remove certain immune cells from the donor's stem cells, aiming to help the child's body recover faster. The main goal was to see if the transplant was even possible, with researchers also tracking survival and infection rates.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
stem cell transplant with immune-suppressing drugs (alemtuzumab, fludarabine, sirolimus)
What this could lead to
If successful, this approach could make stem cell transplants safer and more effective for children with hard-to-treat cancers, potentially improving survival.
What could go wrong
This is a very early (phase I) and small study (23 children). The main goal is just to see if the transplant is feasible, not to prove it works. There are serious risks like infection and graft failure.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.