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Blood pressure breakthrough: new strategy may shield young leukemia patients from crippling bone damage

NCT ID NCT04401267

First seen Nov 01, 2025 · Last updated Jun 16, 2026 · Updated 38 times

Summary

This study looked at whether keeping blood pressure very well controlled (lower than usual) could reduce the risk of a painful bone condition called osteonecrosis in children and young adults being treated for leukemia or lymphoma. 51 participants were randomly assigned to either intensive or standard blood pressure management. The goal was to see if the intensive approach led to fewer bone injuries seen on MRI scans.

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Contacts and locations

Locations

  • St. Jude Affiliate Clinic - Novant Health Hemby Children's Hospital

    Charlotte, North Carolina, 28204, United States

  • St. Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia hypertensive disorder osteonecrosis Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.