Blood pressure drug may shield young cancer patients from crippling bone disease
NCT ID NCT04401267
First seen Jun 25, 2026 · Last updated Jul 21, 2026 · Updated 3 times
Summary
This study tested whether keeping blood pressure in a lower, healthier range could prevent a painful bone condition called osteonecrosis in children and young adults being treated for leukemia. Fifty-one participants were randomly assigned to either intensive or standard blood pressure control. The goal was to see if tighter blood pressure management could reduce bone damage seen on MRI scans.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Intensive Antihypertensive Therapy
- What this could lead to
- If successful, this could lead to a simple way to prevent painful bone damage in children undergoing leukemia treatment.
- What could go wrong
- This is a small, early-phase trial (51 participants) and results may not apply to all patients. Intensive blood pressure control also carries its own risks, like dizziness or low blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
St. Jude Affiliate Clinic - Novant Health Hemby Children's Hospital
Charlotte, North Carolina, 28204, United States
-
St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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