MECHANICAL VENTILATION

This study tests whether a device that automatically controls the pressure of the breathing tube cuff can reduce the risk of pneumonia in critically ill patients on ventilators. About 54 adults who need a breathing tube for at least 3 days will be randomly assigned to either the …

This study tests whether giving an amino acid infusion during and after heart surgery can lower the risk of acute kidney injury in children. About 30 children at high risk for kidney problems will receive either the amino acid or a placebo for up to 72 hours. Researchers will als…

This study tests a new approach to prevent ventilator-associated pneumonia (VAP), a common and serious lung infection in ICU patients on breathing machines. Researchers will use a rapid test (about 4 hours) to identify harmful bacteria in the airway, then give a targeted inhaled …

This study tests whether a procedure using a thin, flexible tube (bronchoscopy) to clear mucus from the lungs can improve lung function in patients on breathing machines who have collapsed lung areas. About 104 adults will be randomly assigned to either standard care or standard …

This study tests whether adding ketamine to standard sedation helps ICU patients on breathing machines. Ketamine treats both pain and anxiety, potentially reducing side effects like confusion and dependence on narcotics. About 54 adults in Canadian ICUs will be randomly assigned …

This study looks at how different levels of ventilator pressure affect blood flow congestion in the abdomen of patients with acute respiratory distress syndrome (ARDS). Researchers will use ultrasound to grade congestion in the liver, kidneys, and portal vein as absent, moderate,…

This study looks at whether a special breathing technique (lung volume optimization maneuver) can improve heart and lung function in 80 children having heart surgery. The approach involves adjusting ventilator settings to find the best lung volume. Researchers will measure blood …

This study observes 100 ICU patients on breathing machines to see if measuring diaphragm movement can predict when they are ready to breathe on their own. The goal is to improve weaning success, avoid re-intubation, and shorten hospital stays. No new treatments are tested—only me…

This study reviews medical records of 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems occur and compare doctors' ventilator settings with a computer algorithm's suggestions. No new treatments a…

This study looks back at medical records from 2,000 adults on breathing machines in the ICU. Researchers want to understand how nutrition-related blood tests change over time and how they relate to patient outcomes like survival and length of hospital stay. The goal is to create …

This study uses a realistic simulator to see if a special 3D lung display, called a 'Digital Twin,' helps ICU doctors feel less stressed and find breathing problems faster. About 34 doctors will try both the standard monitor and the new display during four emergency scenarios. Th…

This study looks at how air moves in the lungs of brain-injured patients when doctors are trying to remove their breathing tube. Researchers will use a special imaging belt (electrical impedance tomography) to see if certain lung ventilation patterns can predict whether the tube …

This study surveys 200 healthcare professionals (doctors, nurses, and students) to find out which techniques they use when removing breathing tubes from patients after surgery or in intensive care. The goal is to describe current practices, not to test a new treatment. Results wi…

This study looks at whether a special ultrasound test, called VExUS, can help doctors know if a patient in the ICU is ready to have their breathing tube removed. About 350 adults who have been on a breathing machine for more than 48 hours will be checked with ultrasound before a …

This study looks at whether a coordinated rehab program in a high-dependency unit (a step-down from the ICU) can improve physical, mental, and thinking skills in 250 adults with post-intensive care syndrome. Participants will receive medical, nursing, and rehab care together. The…

This study tests three different methods of setting breathing machine pressure during robotic surgery to find which one best protects the lungs and improves oxygen levels afterward. About 120 adults having elective robotic surgery will take part. The goal is to see if adjusting p…