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New study to reveal hidden impact of ventilator settings on veins

NCT ID NCT07452952

Knowledge-focused Sponsor: University Hospital, Angers Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how different levels of breathing support (PEEP) affect blood flow congestion in the veins of patients with acute respiratory distress syndrome (ARDS). Researchers will use ultrasound to grade congestion in the liver, kidney, and portal veins as absent, moderate, or severe. The goal is to understand the relationship between ventilator settings and vein congestion, which may help guide better care in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients hospitalized in the Medical Intensive Care and Hyperbaric Medicine Unit of Angers University Hospital, receiving mechanical ventilation in assist-control mode (A/C ventilation), and presenting with ARDS

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients hospitalized in the Medical Intensive Care and Hyperbaric Medicine Unit of Angers University Hospital, receiving mechanical ventilation in assist-control mode (A/C ventilation), and presenting with ARDS as defined by the following criteria (1): * Hypoxemia with a PaO₂ (mmHg)/FiO₂ (0.21 to 1.0) ratio \<300 mmHg with a positive end-expiratory pressure (PEEP) ≥5 cmH₂O; * Pulmonary edema not fully explained by cardiac failure or fluid overload; * Presence of bilateral pulmonary opacities on chest imaging not fully explained by pleural effusions, atelectasis, or pulmonary nodules. Exclusion Criteria: * Minor patient (\<18 years old) * ECMO (Extracorporeal Membrane Oxygenation) * Hemodynamic instability (mean arterial pressure \<60 mmHg) * Respiratory instability (SpO₂ \<90% under FiO₂ \>90%) * Severe organic tricuspid regurgitation * Congenital heart disease * Pneumothorax * Renal or hepatic transplant recipient * Liver cirrhosis Child-Pugh C * Portal vein thrombosis or Budd-Chiari syndrom * Abdominal compartment syndrome documented by intra-abdominal pressure ≥20 mmHg * Pregnant, breastfeeding, or peripartum women * Persons deprived of liberty by judicial or administrative decision * Persons subject to compulsory psychiatric care * Persons under legal protective measures

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome heart failure Hyperemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome (ARDS) Mechanical ventilation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospital of Angers

    Angers, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.