University Hospital, Angers

This study tests whether using a National Early Warning Score (NEWS) to quickly send high-risk blood cancer patients to the ICU can improve survival. About 2,200 adults receiving intensive chemotherapy or stem cell transplants will be enrolled across ten centers. Half the centers…

This study tests whether a custom mouthpiece (mandibular advancement device) can help people with obstructive sleep apnea when they temporarily stop using their CPAP machine. Forty adults who normally use CPAP will either use the mouthpiece or nothing during a two-week CPAP break…

This study compares two blood thinners in people with leg injuries that require a cast or brace. About 1,400 high-risk participants will receive either a daily pill (rivaroxaban) or daily injections (LMWH) for several weeks. The goal is to see if the pill is as good or better at …

This study tests whether coordinated care between general practitioners, physiotherapists, and occupational health services can reduce long-term disability in people with subacute or recurrent acute low back pain. About 500 participants will receive either standard care or a coor…

This study tests whether giving stroke patients a personalized nutrition plan within 2 days of their stroke can lower the risk of death within the first month. About 3,084 adults with moderate to severe stroke will take part. A dietitian will check for swallowing problems and adj…

This study tests a treatment called extracorporeal phototherapy (ECP) for people whose kidney transplants are failing due to chronic antibody-mediated rejection. ECP involves taking a patient's blood cells, treating them with a light-activated drug and UVA light, then returning t…

This study aims to see which of two blood tests, eLIFT or FibroMeter, is better at finding advanced liver scarring (fibrosis) in people with fatty liver disease or alcohol-related liver disease. About 1,788 adults from primary care clinics will take both tests. The goal is to imp…

This study compares two step-by-step approaches to diagnose advanced liver fibrosis in people with NAFLD (fatty liver disease). Both methods start with a simple blood test, then use a more advanced test only if needed, aiming to avoid invasive liver biopsies. About 1,045 particip…

This study tests a new way to diagnose knee sprains using a quick scan called Automated Dynamic Laximetry (LDA) instead of the usual MRI. About 80 adults with suspected ACL injuries will be split into two groups: one gets LDA first, the other gets MRI. The goal is to see if LDA c…

This study tests two different exercise programs using exergames (video games that require physical movement) in 40 adults with early-stage Huntington's disease. One program combines physical and mental tasks at the same time, while the other does them separately. The goal is to …

This pilot study tests whether doing visual brain exercises on a touchscreen for 30 minutes every other day can improve attention and thinking speed in older adults with mild cognitive impairment. Forty participants aged 60 and older will either do the exercises or watch a TV pro…

This study looks at whether medical honey can help heal wounds in intensive care patients better than standard care. About 60 adults with fresh wounds (like pressure sores or cuts) will be randomly assigned to get either honey dressings or usual treatment. The main goal is to see…

This study tests a 10-week treadmill training program combined with blood flow restriction (BFR) to see if it can improve walking speed in children aged 8 to 18 with cerebral palsy. The goal is to make rehabilitation more effective and less time-consuming. The study will enroll 1…

This study tests whether people with liver cancer can receive a treatment that goes through an artery (like chemo or radiation beads) as an outpatient instead of staying in the hospital. About 206 adults with liver cancer will be randomly assigned to either outpatient or standard…

This study tests a new home-based program that uses a special treadmill and virtual reality to help children with conditions like cerebral palsy, muscle diseases, or obesity improve their walking. About 30 children aged 6 to 17 will try the program at home for at least 3 sessions…

This study looks at whether regular karate practice can boost the quality of life, self-esteem, and sleep of medical students, who often face high stress and anxiety. Researchers will enroll 90 third- or fourth-year health students at the University of Angers. Participants will p…

This study aims to find blood-based biomarkers that can predict whether a child with acute disseminated encephalomyelitis (ADEM) will experience relapses. Researchers will analyze immune cells from blood samples of 20 children aged 1-18 with a first demyelinating event. The goal …

This study compares how people with chronic insomnia and healthy controls recognize facial emotions. Using eye-tracking, researchers will look for subtle differences in attention and emotional processing. The goal is to better understand social challenges linked to insomnia and i…

This study looks at a newly identified condition called FIRE (Food Induced Immediate Response of the Esophagus) in children with eosinophilic esophagitis. Researchers want to find out how common FIRE is and describe its symptoms, like chest pain or choking within minutes of eatin…

This study looks at whether a special eye scan can detect early blood flow changes in the retina of people with pseudoxanthoma elasticum (PXE), a rare genetic disease that can cause vision loss. Researchers will compare 30 PXE patients with 30 healthy volunteers matched by age an…

This study is collecting blood, urine, and stool samples from 300 people with cirrhosis to build a biobank. Researchers will later use these samples to understand how factors like nutrition, physical activity, smoking, alcohol, and pollution influence the development of the most …

This study is testing a brain-mapping technique called high-resolution electrical source imaging (HR-ESI) to see if it can predict which children with hard-to-treat epilepsy will become seizure-free after surgery. Researchers will enroll 120 children aged 2 to 17 who are candidat…

This study looks at whether new MRI techniques can spot NASH, the serious form of fatty liver disease, without needing a liver biopsy. Researchers will scan 110 adults who already need a biopsy to see if the MRI can match the biopsy results. If successful, it could lead to a safe…

This study looks at two different approaches to deciding when to place a breathing tube in patients with acute hypoxemic respiratory failure (dangerously low oxygen levels). One strategy is more liberal (intubate earlier to prevent complications from low oxygen), while the other …

This study looks at whether raising blood pressure to a higher target (80-85 mmHg) improves kidney function in adults with shock and high central venous pressure. About 30 participants will be monitored. The goal is to learn if personalized blood pressure targets can protect the …

This study is testing how to safely perform skin allergy tests in people receiving biotherapies for cancers and blood disorders. Researchers will find the highest concentration of each biotherapy that does not cause a skin reaction in 9 out of 10 patients. The goal is to establis…

This study looks at whether adding certain natural substances (metabolites) to blood cells from septic shock patients can improve the function of mitochondria, the cell's power plants. Researchers will collect blood samples from 55 adults in the ICU and test different metabolites…

This study is testing a new questionnaire called PETRA that uses pictures to help people with suspected thoracic outlet syndrome describe which daily tasks they avoid because of their symptoms. The questionnaire also asks how often they face those tasks, giving doctors a clearer …

This study follows 9 healthy young adults living for a year on the remote Kerguelen Islands to see how extreme isolation and stress affect their immune systems. Researchers collect blood, saliva, stool, urine, and hair samples every three months to track immune cells, hidden viru…

This study looks at whether measuring CALR gene mutation levels over time can help predict when a type of blood cancer (myeloproliferative neoplasm) gets worse. Researchers will follow 260 adults diagnosed between 2006 and 2020, using stored blood samples and new tests. No new tr…

This study is testing a new, simple questionnaire called SAPHIR to see if it can accurately measure how physically active people are. Researchers will compare the questionnaire results with data from an activity monitor worn by 118 adults. The goal is to create an easy tool for d…

This study looks at whether giving extra oxygen through a mask (normobaric oxygen therapy) can help people with critical limb ischemia, a severe lack of blood flow to the legs that can lead to amputation. Researchers will compare the health and treatments of 200 patients who do o…

This study looks at whether regularly measuring the amount of pembrolizumab (an immunotherapy drug) in the blood can help doctors better treat non-small cell lung cancer. The goal is to see if this monitoring can improve how well the drug works and reduce side effects. About 75 a…

This study looks at how specific genetic changes (ASXL1 mutations) affect the course of myelofibrosis, a rare bone marrow cancer. Researchers will analyze blood and bone marrow samples from 50 adults to identify different patterns of these mutations. The goal is to better predict…

This study looks at whether people with a rare inherited movement disorder called spinocerebellar ataxia have trouble recognizing emotions or understanding social situations. Researchers will compare 160 patients to healthy volunteers using tests like recognizing facial expressio…

This study follows children and teens who had radiation to the brain before age 16 to check for hormone problems. Researchers will measure hormone levels and track fatigue to create better follow-up guidelines. About 230 participants in remission from cancer will be monitored for…

This study aims to see if a common blood test (FIB4) can help find people with advanced liver scarring who don't yet know they have it. About 500 adults aged 18-70 with a high FIB4 result will get a liver stiffness scan and, if needed, a biopsy to confirm the diagnosis. The goal …

This study looks at a type of immune cell called monocytes in people with certain blood cancers (polycythemia vera, essential thrombocythemia, and myelofibrosis). Researchers want to see if these cells have unique features that could help diagnose or understand the diseases bette…

This study looks at how two different levels of breathing support (called PEEP) affect lung function in patients with a severe lung condition called ARDS. The researchers want to see if the response differs based on the patient's lung stiffness. They will use a special imaging te…

This study looks at whether changing the tubes that deliver medicine through a central line every 7 days is just as safe as changing them every 4 days for ICU patients. The goal is to see if a longer interval can prevent infections while also reducing the workload on nurses and c…

This study looks at why women often have worse outcomes than men after a heart attack. Researchers think it may be due to differences in how the heart changes shape and size during recovery. They will follow 1,650 people who had their first major heart attack, using imaging to tr…

This study looks at whether using telemedicine and care plans tailored to a patient's age and symptoms can help more people with the rare genetic condition PXE get the follow-up care they need. Researchers will compare the number of patients properly monitored before and after th…

This study looks at whether measuring oxygen levels in urine can help predict kidney injury or recovery in patients with shock. Shock is a life-threatening condition where organs don't get enough oxygen. The study will include 55 intensive care unit patients, some with shock and …

This study is for adults with polycythemia vera, essential thrombocythemia, or pre-myelofibrosis who are starting their first treatment. Researchers want to find out why some patients respond well to standard drugs while others do not. They will look at genetic and immune system …

This study looks at whether the amount and type of gas a person passes after abdominal surgery can help predict complications. Researchers will track 200 adults before and after surgery, asking them to record details about their gas. The goal is to see if gas quality can serve as…

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study looks at memory, concentration, and language problems caused by chemotherapy in people with blood cancers like leukemia and lymphoma. Researchers will compare 120 patients to their healthy relatives using tests and questionnaires before and after treatment. The goal is…

This study looks at whether giving special simulation training to medical interns helps them break the news of an early pregnancy loss more gently. About 1,000 women who had a miscarriage before 14 weeks will take part. The goal is to see if better communication from doctors can …

This study looks at how ALS (Lou Gehrig's disease) affects social thinking, like recognizing emotions in faces and voices. Researchers will compare 74 ALS patients to healthy volunteers using video-based tests. The goal is to better understand these challenges, which can impact d…