University Hospital, Angers

This study is testing whether starting personalized nutrition support within two days of a severe stroke can help reduce deaths in the first month. In the test group, a dietitian will assess each patient and create a feeding plan, which may include special foods or tube feeding i…

This study compares a new automated test (LDA) to MRI for diagnosing knee sprains. Researchers want to see if LDA can confirm injuries faster and at lower cost, while reserving MRI for complex cases. About 80 adults with suspected ACL tears will be enrolled.

This study compares two step-by-step strategies that use simple blood tests first, then more advanced scans only if needed, to accurately diagnose advanced liver fibrosis in people with NAFLD. Over 1,000 participants will be enrolled to see which approach works best. The goal is …

This study tests whether a coordinated care team—including general practitioners, physiotherapists, and occupational health services—can reduce long-term disability in people with subacute or recurrent acute low back pain. About 500 adults with jobs will either receive standard c…

This study aims to find biological markers that can predict whether a child with acute disseminated encephalomyelitis (ADEM) will have a relapse. Researchers will analyze blood samples from 20 children using advanced genetic sequencing. The goal is to identify children at high ri…

This study looks at whether adding specific nutrients to cells from septic shock patients can fix damaged mitochondria, the cell's energy factories. Researchers will take blood samples from 55 adults in the ICU and test these nutrients in the lab. The goal is to understand if thi…

This study looks at blood flow in the back of the eye in people with pseudoxanthoma elasticum (PXE), a rare genetic disease that can cause vision loss. Researchers will compare eye scans from 60 participants — half with PXE and half healthy — to see if reduced blood flow can serv…

This study looks at why women often have worse outcomes than men after a heart attack. Researchers will track changes in heart size and shape in 1,650 participants using imaging tests. The goal is to understand these differences and improve future care.

This study looks at how people with a rare inherited brain condition called spinocerebellar ataxia (SCA) understand emotions and social situations. Researchers will test 160 adults using face-recognition tasks, story-based tests, and video scenarios. The goal is to identify speci…

This study looks at whether measuring oxygen levels in urine can help predict kidney injury or recovery in people with shock. Shock is a life-threatening condition where organs don't get enough oxygen. The study will include 55 intensive care patients, some with shock and some wi…

This study is testing a new questionnaire called PETRA for people with suspected thoracic outlet syndrome, a condition that affects the nerves and blood vessels between the neck and shoulder. The questionnaire asks about how often people do everyday tasks and how much they avoid …

This study looks at whether special training for doctors-in-training, using simulated scenarios, can help them break the news of an early pregnancy loss more sensitively. Researchers will compare the emotional well-being of 1000 patients who received the news from trained versus …

This study looks at whether changes in a gene called CALR can help doctors predict when certain blood cancers (myeloproliferative neoplasms) get worse. Researchers will follow 260 adults diagnosed between 2006 and 2020, using stored blood samples to track the gene over time. The …

This study follows 9 healthy young adults living for one year on the remote Kerguelen Islands in the sub-Antarctic. Researchers will collect blood, saliva, stool, urine, and hair samples every three months to see how isolation, stress, and disrupted sleep affect the immune system…

This study looks at whether raising blood pressure to a higher target can improve kidney function in people with shock and high pressure in the veins near the heart. About 30 adults on strong blood pressure medication will be tested. The goal is to learn how to better personalize…

This study looks at how people with ALS (Lou Gehrig's disease) understand social situations, like reading facial expressions and tone of voice. Researchers will compare 74 ALS patients to healthy volunteers using video-based tests. The goal is to learn more about how social think…

This study looks at whether using telemedicine and care plans tailored to a patient's age and symptoms can help more people with the rare genetic disorder PXE get the follow-up care they need. Researchers will track 650 patients over several years to see if this new approach impr…

This study looks at whether using a simple early warning score (based on vital signs like heart rate and breathing) can help doctors spot problems sooner in blood cancer patients receiving strong chemotherapy. About 2,200 adults will take part across 10 hospitals. Half the hospit…

This study compares facial emotion recognition between 128 adults with chronic insomnia and healthy controls. Participants complete emotion recognition tests while eye-tracking measures attention. The goal is to understand if insomnia causes subtle social perception problems, whi…

This study looks at 75 adults with non-small cell lung cancer who are receiving pembrolizumab (Keytruda). Researchers want to see if the amount of drug in a patient's blood is linked to how well the cancer shrinks or if side effects occur. By monitoring drug levels over time, the…

This study looks at 120 adults with certain blood cancers (polycythemia vera, essential thrombocythemia, or pre-myelofibrosis) who are starting their first treatment. Researchers want to find out why some patients respond well to standard drugs (hydroxyurea or pegylated interfero…

This study aims to find better ways to diagnose NASH, a serious liver condition, using MRI scans instead of a liver biopsy. Researchers will enroll 60 adults with fatty liver disease who already need an MRI. The goal is to see if new MRI measurements can accurately detect NASH, p…

This study looks at how changes in the ASXL1 gene affect myelofibrosis, a rare bone marrow disorder. Researchers will study 50 adults to find different patterns of these gene changes and see how they relate to patient outcomes. The goal is to better understand the disease and imp…