Scientists decode genetic clues in rare bone marrow cancer
NCT ID NCT05710211
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how specific genetic changes (ASXL1 mutations) affect the course of myelofibrosis, a rare bone marrow cancer. Researchers will analyze blood and bone marrow samples from 50 adults to identify different patterns of these mutations. The goal is to better predict how the disease will progress and guide future treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2023
- Expected to finish
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Apr 2031
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults (age ≥18 years), * Affiliated to the national social security system, * ASXL1 mutated primary or secondary myelofibrosis, * Signed the consent to participate in the study, * Included, or consenting to be included, in the national clinical-biological database of France Intergroupe Syndrome Myéloprolifératifs (FIM). Exclusion Criteria: * Patient with another active hematological disease or cancer at the time of diagnosis, * Person subject to legal protection scheme or incapable of giving consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
13 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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AP-HP Hôpital Saint Louis
NOT_YET_RECRUITINGParis, 75010, France
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CH Cholet
NOT_YET_RECRUITINGCholet, France
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CH de Cornouaille
NOT_YET_RECRUITINGQuimper, France
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CH de Vannes
NOT_YET_RECRUITINGVannes, France
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CHRU Brest
NOT_YET_RECRUITINGBrest, France
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CHRU Tours - Hôpital Bretonneau
RECRUITINGTours, France
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CHU Angers
RECRUITINGAngers, France
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CHU Henri MONDOR
RECRUITINGCréteil, 94010, France
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CHU Lyon
RECRUITINGPierre-Bénite, 69495, France
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CHU Nantes
NOT_YET_RECRUITINGNantes, France
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CHU de Bordeaux
RECRUITINGPessac, 33604, France
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Hôpital Bicêtre
RECRUITINGParis, France
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Institut Paoli Calmettes
RECRUITINGMarseille, 13009, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Half-Matched stem cells tested as cure for myelofibrosis
- Can blood tests predict transplant complications?
- Can a new daily pill shrink the spleen and ease myelofibrosis symptoms?
- Can a new pill tame myelofibrosis?
- MRI as a window into bone marrow disease: a new biomarker test?
- Can a menin inhibitor tame myelofibrosis when standard drugs fall short?