University Hospital, Angers

This study tests whether giving stroke patients a personalized nutrition plan within two days of their stroke can lower the chance of dying within 30 days. About 3,000 adults with moderate to severe stroke will take part. A dietitian will check each patient's swallowing and eatin…

This study tests whether a custom mouthpiece (mandibular advancement device) can help control sleep apnea symptoms and heart risks when people temporarily stop using their CPAP machine. About 40 adults who have used CPAP for over a year will be randomly assigned to use the mouth …

This study compares two blood thinners—rivaroxaban (a pill) and low-molecular-weight heparin (a daily shot)—in people with leg injuries that require a cast or brace. About 1,400 high-risk participants will be randomly assigned to one treatment and followed for 90 days. The goal i…

This study aims to see which of two blood tests, eLIFT or FibroMeter, is better at finding advanced liver scarring (fibrosis) in people with fatty liver disease or alcohol-related liver disease. About 1,788 adults from primary care clinics will take both tests. The goal is to imp…

This study compares two step-by-step approaches to diagnose advanced liver fibrosis in people with NAFLD (fatty liver disease). Both methods start with a simple blood test, then use a more advanced test only if needed, aiming to avoid invasive liver biopsies. About 1,045 particip…

This study tests a new way to diagnose knee sprains using a quick scan called Automated Dynamic Laximetry (LDA) instead of the usual MRI. About 80 adults with suspected ACL injuries will be split into two groups: one gets LDA first, the other gets MRI. The goal is to see if LDA c…

This study tests whether people with liver cancer can receive a treatment that goes through an artery (like chemo or radiation beads) as an outpatient instead of staying in the hospital. About 206 adults with liver cancer will be randomly assigned to either outpatient or standard…

This study tests a new home-based program that uses a special treadmill and virtual reality to help children with conditions like cerebral palsy, muscle diseases, or obesity improve their walking. About 30 children aged 6 to 17 will try the program at home for at least 3 sessions…

This study looks at whether a coordinated care team—including general practitioners, physiotherapists, and occupational health services—can help people with subacute or recurrent low back pain avoid long-term disability. About 500 adults with active jobs will be assigned to eithe…

This study tests whether doing special visual exercises on a computer can improve attention and thinking speed in older adults with mild cognitive impairment. About 40 people aged 60 and older will either do the exercises or watch TV for 30 days. Researchers will compare changes …

This study compares two different exercise programs using video games (exergames) to see if they can improve balance, thinking, and behavior in people with Huntington's disease. The study will involve 40 adults with early-stage Huntington's. Each program combines physical activit…

This study looks at whether regular karate practice can boost the quality of life, self-esteem, and sleep of medical students, who often face high stress and anxiety. Researchers will enroll 90 third- or fourth-year health students at the University of Angers. Participants will p…

This study tests whether medical honey can help heal wounds faster and with less pain in intensive care patients. About 60 adults with fresh wounds will be randomly assigned to receive either honey dressings or standard care. The main goal is to measure wound size reduction after…

This study tests whether adding immersive virtual reality (VR) to standard rehabilitation can improve arm function and reduce pain in people with Complex Regional Pain Syndrome (CRPS). Twelve adults with chronic upper-limb pain will use VR during occupational therapy sessions. Re…

This study looks at whether giving extra oxygen through a mask (normobaric oxygen therapy) can help people with critical limb ischemia, a severe lack of blood flow to the legs that can lead to amputation. Researchers will compare the health and treatments of 200 patients who do o…

This study looks at blood flow in the back of the eye in people with pseudoxanthoma elasticum (PXE), a rare genetic disease that can cause vision loss. Researchers will compare eye scans from 60 participants (30 with PXE and 30 healthy volunteers) to see if early changes in blood…

This study looks at whether regularly measuring the amount of pembrolizumab (an immunotherapy drug) in the blood can help doctors better treat non-small cell lung cancer. The goal is to see if this monitoring can improve how well the drug works and reduce side effects. About 75 a…

This study looks at how specific genetic changes (ASXL1 mutations) affect the course of myelofibrosis, a rare bone marrow cancer. Researchers will analyze blood and bone marrow samples from 50 adults to identify different patterns of these mutations. The goal is to better predict…

This study looks at whether people with a rare inherited movement disorder called spinocerebellar ataxia have trouble recognizing emotions or understanding social situations. Researchers will compare 160 patients to healthy volunteers using tests like recognizing facial expressio…

This study looks at whether people with chronic insomnia have trouble recognizing emotions on others' faces. Researchers will compare a group with insomnia to a group without, using special eye-tracking tests. The goal is to understand social difficulties linked to poor sleep and…

This study looks at whether changes in a gene called CALR can help doctors predict if a type of blood cancer (myeloproliferative neoplasm) will get worse. Researchers will track 260 adults diagnosed between 2006 and 2020. No new treatment is given; the goal is to learn if monitor…

This study follows children and teens who had radiation to the brain before age 16 to check for hormone problems. Researchers will measure hormone levels and track fatigue to create better follow-up guidelines. About 230 participants in remission from cancer will be monitored for…

This study looks at whether new MRI techniques can detect NASH, the serious form of fatty liver disease, without needing a liver biopsy. Researchers will compare MRI results with biopsy findings in 60 adults already scheduled for both tests. If successful, this could lead to a sa…

This study aims to see if a common blood test (FIB4) can help find people with advanced liver scarring who don't yet know they have it. About 500 adults aged 18-70 with a high FIB4 result will get a liver stiffness scan and, if needed, a biopsy to confirm the diagnosis. The goal …

This study looks at a type of immune cell called monocytes in people with certain blood cancers (polycythemia vera, essential thrombocythemia, and myelofibrosis). Researchers want to see if these cells have unique features that could help diagnose or understand the diseases bette…

This study looks at how two different levels of breathing support (called PEEP) affect lung function in patients with a severe lung condition called ARDS. The researchers want to see if the response differs based on the patient's lung stiffness. They will use a special imaging te…

This study is testing a new, simple questionnaire called SAPHIR that measures how active people are. Researchers will ask 118 adults to fill out the questionnaire and wear an activity monitor for a week. The goal is to see if the quick quiz gives the same results as the monitor, …

This study looks at whether adding specific nutrients to cells from septic shock patients can restore mitochondrial function—the cell's energy factories. Researchers will collect blood cells from 55 adults in the ICU and test these nutrients in the lab. The goal is to understand …

This study looks at whether changing the tubes that deliver medicine through a central line every 7 days is just as safe as changing them every 4 days for ICU patients. The goal is to see if a longer interval can prevent infections while also reducing the workload on nurses and c…

This study looks at whether increasing blood pressure can improve kidney function in people with shock who also have high pressure in their veins near the heart. About 30 adults on strong blood pressure medication will be monitored. The goal is to see if a higher blood pressure t…

This study looks at two ways doctors decide when to put a breathing tube in patients with severe low oxygen levels. One approach is to intubate early to prevent harm from low oxygen, while the other waits longer to avoid risks of the breathing machine. The goal is to find which s…

This study looks at whether a special brain-mapping technique (HR-ESI) can predict if epilepsy surgery will work for children with hard-to-control seizures. About 120 kids aged 2 to 17 will get this test before surgery. The goal is to see if the test can tell which children will …

This study looks at why women often have worse outcomes than men after a heart attack. Researchers think it may be due to differences in how the heart changes shape and size during recovery. They will follow 1,650 people who had their first major heart attack, using imaging to tr…

This study looks at whether using telemedicine and care plans tailored to a patient's age and symptoms can help more people with the rare genetic condition PXE get the follow-up care they need. Researchers will compare the number of patients properly monitored before and after th…

This study looks at whether measuring oxygen levels in urine can help predict kidney injury or recovery in patients with shock. Shock is a life-threatening condition where organs don't get enough oxygen. The study will include 55 intensive care unit patients, some with shock and …

This study is testing a new questionnaire called PETRA for people with suspected thoracic outlet syndrome, a condition that affects the nerves and blood vessels between the neck and shoulder. The questionnaire uses pictures to ask about which daily tasks people avoid and how ofte…

This study is for adults with polycythemia vera, essential thrombocythemia, or pre-myelofibrosis who are starting their first treatment. Researchers want to find out why some patients respond well to standard drugs while others do not. They will look at genetic and immune system …

This study looks at whether the amount and type of gas a person passes after abdominal surgery can help predict complications. Researchers will track 200 adults before and after surgery, asking them to record details about their gas. The goal is to see if gas quality can serve as…

This study aims to learn more about a newly described condition called FIRE (Food Induced Immediate Response of the Esophagus) in children aged 6 to 17 who already have eosinophilic esophagitis. Researchers want to find out how common FIRE is and what symptoms it causes, like pai…

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study follows 9 healthy young adults living for one year on the remote Kerguelen Islands to understand how extreme isolation and stress affect the immune system. Researchers will collect blood, saliva, stool, urine, and hair samples every three months to track changes in imm…

This study looks at whether using a simple early warning score (called NEWS) can help doctors spot when blood cancer patients on strong chemotherapy are getting sicker, and then move them to the intensive care unit (ICU) sooner. The goal is to see if this approach reduces deaths …

This study looks at memory, concentration, and language problems caused by chemotherapy in people with blood cancers like leukemia and lymphoma. Researchers will compare 120 patients to their healthy relatives using tests and questionnaires before and after treatment. The goal is…

This study aims to find biological markers in the blood that can predict whether a child with acute disseminated encephalomyelitis (ADEM) will have relapses. ADEM is a rare brain inflammation that can cause coma and long-term problems. Researchers will analyze immune cells from 2…

This study looks at whether giving special simulation training to medical interns helps them break the news of an early pregnancy loss more gently. About 1,000 women who had a miscarriage before 14 weeks will take part. The goal is to see if better communication from doctors can …

This study looks at how ALS (Lou Gehrig's disease) affects social thinking, like recognizing emotions in faces and voices. Researchers will compare 74 ALS patients to healthy volunteers using video-based tests. The goal is to better understand these challenges, which can impact d…

This study tests whether a treatment called extracorporeal phototherapy (ECP) can help kidney transplant patients whose bodies are slowly rejecting the new kidney. ECP involves taking some of the patient's blood cells, treating them with ultraviolet light, and returning them to t…