University Hospital, Angers

This study looks back at 90 children treated for pilonidal sinus disease to see which surgical technique works best. The goal is to find the method that leads to the fastest healing and lowest chance of the problem coming back. Results will help doctors choose the best surgery fo…

This study looks at different surgical techniques for treating Hirschsprung disease, a rare condition where part of the colon lacks nerve cells, causing bowel blockages. Researchers will compare a newer single-port laparoscopic method with traditional approaches in 70 children un…

This early study tests whether high-dose vitamin B3 (nicotinamide) can help preserve or improve vision in people with Leber's hereditary optic neuropathy (LHON), a rare genetic disease that causes sudden vision loss. Researchers will give 13 participants 2 grams of vitamin B3 dai…

This study tests a simple 10-item checklist that parents can use during a video call to help doctors figure out if a child's belly pain is appendicitis. About 1,500 children aged 3 to 16 with stomach pain will try the checklist with a medical student, then get standard care. The …

This study tests whether a short, one-on-one talk with a specially trained nurse in the pediatric emergency room can help parents of babies under 6 months follow safe sleep guidelines. About 100 parents will be interviewed to understand why some babies sleep in unsafe positions o…

This study looks at whether people with a moderate-risk blood clot in the lungs can be safely treated at home instead of staying in the hospital. About 568 adults will be randomly assigned to either go home early or receive standard hospital care. The goal is to see if home treat…

This study looks at two methods to control pain after hindfoot surgery: a single nerve block injection versus a small tube (catheter) that delivers numbing medicine continuously for days. The goal is to see which approach reduces pain, cuts down on opioid use, and helps people re…

This study looks at how changing the pressure in a ventilator affects blood flow congestion in the abdomen of people with acute respiratory distress syndrome (ARDS). Researchers will use ultrasound to grade congestion in the liver, kidneys, and portal vein as absent, moderate, or…

This study looks at whether dangerous blood clots in the lungs (pulmonary embolism) are often missed in people hospitalized with acute heart failure. About 740 adults will take part across multiple hospitals. Half the hospitals will test everyone for clots; the other half will us…

This study looks at whether the force of mechanical ventilation used in acute respiratory distress syndrome (ARDS) can cause brain injury. Researchers will measure a brain-damage marker called S100B in 150 adults and test their memory and thinking skills 3 and 12 months later. Th…

This study aims to measure how human seminal plasma allergy (HSPA) affects the quality of life of affected women. Researchers will use existing questionnaires to assess physical, mental, and sexual health in 20 adult patients. The goal is to better understand the condition's impa…

This study looks at the best way to remove a temporary brain drain (external ventricular drain) in patients who had a brain bleed. The drain helps relieve pressure, but keeping it in too long raises infection risk. Researchers will compare two weaning methods—direct clamping vers…

This study looks at how to safely test for allergic reactions to biotherapies (special drugs used to treat cancer and other diseases). Researchers will test different concentrations of these drugs on the skin of 70 cancer patients who have not had allergic reactions, to find the …

This study looks at how people with Huntington's disease remember personal events and imagine future ones. Researchers will use eye-tracking technology alongside memory tests to find patterns linked to memory difficulties. The goal is to better understand these cognitive challeng…

This study looks at children with spinal dysraphism (a spine defect present at birth) to better understand how it affects their bladder and bowel function. Researchers will review medical records of 210 children treated at one hospital over 10 years. The goal is to learn more abo…

This study looks at children who had surgery for a blocked duodenum (the first part of the small intestine) at birth. The goal is to find out how often bile duct and pancreas problems happen after that surgery. Researchers will review medical records from the past 20 years across…

This study looks at how certain thinking skills, called executive functions, are linked to suicidal thoughts and actions in teenagers. Researchers will test 100 adolescents aged 11 to 16 who are in the hospital for suicidal behavior. The goal is to find patterns that could lead t…