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Can a pacemaker for the diaphragm save more donor lungs?

NCT ID NCT07505589

Knowledge-focused Sponsor: Fraser Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small study tested a device that paces the diaphragm in brain dead organ donors whose lungs were too damaged for transplant. The goal was to see if this approach could improve lung function enough to make the lungs usable. Only 3 people took part, so the results are very early and mainly show that the procedure is possible and safe.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

3 people

The number who actually took part.

Started

Jan 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Designated as brain dead according to BC provincial guidelines, and * Are 19 years or older, and * Are mechanically ventilated, and * TSDM consented for organ donation, and * TSDM consented to study participation, and * Accepted by BC transplant team to donate at least 1 organ system, and * Declined by BC transplant team for lung donation based on hypoxia with the PaO2/FiO2ratio \< 300 mmHg or other criterion that precludes lung donation as requested by the organ donation team. Exclusion Criteria: * Greater than 8 hours from time declined for lung donation and initiation of LAPS-PNS, * Inability to place a central venous catheter in the left internal jugular or left subclavian vein, * Neuromuscular disease (e.g., Amyotrophic Lateral Sclerosis, Guillain-Barre), * Previous phrenic nerve injury, * Spinal cord injury above the 6th cervical spine level, * Implanted electronic cardiac or neurostimulation device in situ * 2nd or 3rd degree heart block on at least 2 EKGs conducted during routine care, * Treating physician deems enrollment not clinically appropriate for other reason

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Conditions

The condition(s) this trial relates to.

lung neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG Mechanical ventilation Organ donation

Contacts and locations

Locations

  • Royal Columbian Hospital

    New Westminster, B.C., V3L 3W7, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.