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Ventilator study aims to Fine-Tune breathing support for surgery patients

NCT ID NCT07199881

Knowledge-focused Sponsor: Mahidol University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the breathing drive and effort of patients in the ICU change when the ventilator pressure support is adjusted. Forty adults who had major abdominal surgery and are on a breathing machine will have their ventilator settings changed in small steps. Researchers will measure breathing effort using non-invasive tests to find the best support level and reduce complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors set ventilators more precisely for patients after abdominal surgery, potentially reducing breathing complications.
What could go wrong
This is a small, early observational study with only 40 participants, so findings may not apply to all patients. It measures breathing patterns but does not test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (≥18 years) admitted to the surgical ICU * Recent major abdominal surgery (intra-peritoneal operation without primary thoracic involvement, including luminal resection and/or resection of a gastrointestinal solid organ) requiring postoperative ICU care * Receiving invasive mechanical ventilation in pressure support ventilation (PSV) mode at the time of enrollment * Duration of invasive mechanical ventilation \>48 hours * Clinically stable, with no plan for extubation within 6 hours of study enrollment, defined by all of the following: Respiratory rate \<35 breaths/min, SpO₂ ≥90%, Heart rate \<140 bpm, No visible accessory muscle use, Hemodynamically stable without escalation of vasopressor support during the past hour, Able to tolerate short-term adjustments in PSV level as per protocol Exclusion Criteria: * Known neuromuscular disease affecting respiratory muscle function * Hemodynamic instability requiring escalation of vasopressor support * Severe hypoxemic respiratory failure requiring Positive End-Expiratory Pressure (PEEP) \>10 cmH₂O or FiO₂ \>60% * Deep sedation (Richmond Agitation-Sedation Scale \[RASS\] score \< -3) or ongoing neuromuscular blockade * History of chronic obstructive pulmonary disease (COPD) or other obstructive lung disease

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inspiratory effort Major abdominal surgeries Mechanical ventilation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Medicine, Siriraj Hospital, Mahidol University

    RECRUITING

    Bangkok, Bangkoknoi, 10700, Thailand

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