CONGENITAL HEART DISEASE

This study tests a heart-lung support device (Cardiohelp) in 50 children with severe heart failure to see if it is safe and effective for up to 30 days. It also compares two blood thinners (heparin vs. bivalirudin) to find which causes fewer bleeding or clotting problems. The goa…

This study tests whether a drug called sacubitril-valsartan can improve heart structure and function in adults with congenital heart disease. About 45 participants will be randomly assigned to receive the drug or a placebo. The goal is to see if the drug helps the heart pump bett…

This study tests whether a home-based digital exercise program can increase physical activity and fitness in children aged 10-17 with Fontan circulation, a heart condition from single-ventricle defects. Two hundred participants will wear activity trackers for 12 months and be ran…

This early-stage trial tests whether heart cells grown from a patient's own stem cells can be safely given to people with severe congenital heart disease. About 50 participants will receive the cells or be in a comparison group. The main goal is to check for serious side effects …

This study tests a special stent designed to keep a small heart vessel open in babies under 6 months old who have a congenital heart defect. The stent helps blood flow to the lungs, reducing the need for immediate open-heart surgery. Researchers will check if the stent is safe an…

This study tests whether a high-energy formula helps infants with congenital heart disease grow and develop their brains better after open-heart surgery. About 160 babies aged 0-6 months will receive either high-energy or standard nutrition. The goal is to see if the extra calori…

This study tests if a home-based video game exercise bike can improve fitness in 44 teens (ages 10-18) with repaired congenital heart disease. Participants use the MedBIKE for high-intensity interval training, guided remotely by a coach. The goal is to see if this fun, telemedici…

This study tests whether a 12-week home-based high-intensity interval training program can improve exercise capacity in people aged 12 to 45 with a congenital heart defect that required a surgical connection between the right heart chamber and lung artery. Participants will be as…

This study looks at 200 infants under 1 year old who had heart surgery for congenital heart disease. After their breathing tube is removed, they will get one of two standard breathing supports: high flow nasal cannula or non-invasive positive pressure ventilation. The goal is to …

This study tests an online program that helps parents of children with congenital heart disease (ages 3-9) improve their parenting skills and manage child behavior. About 382 families from SickKids in Ontario will take part. The program is designed to be convenient and supportive…

This study looks at how growing up with a heart condition can affect mental health, specifically post-traumatic stress disorder (PTSD). Researchers will survey 1,000 adults with congenital heart disease to find out what experiences (like painful surgeries or bullying) raise the r…

This study tests whether wrist-worn devices can safely monitor pregnant women with congenital heart disease at home. Researchers will track heart rhythms and other data from 50 participants to see if early warning signs of complications can be detected. The goal is to improve car…

This study looks at how certain immune cells (monocytes) change during heart surgery that uses a heart-lung machine. Researchers will measure these cells and related chemicals in the blood before, during, and after surgery. The goal is to understand links between inflammation and…

This study tests whether a personalized lung inflation technique can improve heart and lung function in two groups of children on breathing machines: those recovering from heart surgery and those with severe respiratory failure. Researchers will measure how well the lungs and hea…

This study collects heart pressure and blood flow data from 50 healthy adults to create a comparison group for a larger registry of people with congenital heart disease. Participants must have no heart conditions, not take heart medications, and meet health criteria. The goal is …

This study tests whether a Parent Navigator Program helps Latino/x parents of babies with congenital heart disease connect to developmental follow-up services. About 40 families will be randomly assigned to either the navigator program or standard care. Researchers will track cli…

This study looks at whether special pacemakers can safely and effectively stop rapid atrial arrhythmias in people with congenital heart disease. Researchers will review medical records from up to 300 patients over 5 years before and after pacemaker placement. The goal is to see w…

This study is testing a smartphone app called Empower My Congenital Health (EmpowerMyCH) designed to help adults with congenital heart disease feel more confident managing their own healthcare. The app includes a digital medical passport, educational information, community suppor…

This study is collecting information from 400 adults with congenital heart disease who are taking a type of diabetes drug called SGLT2 inhibitors. Researchers want to see how doctors prescribe these drugs, whether they cause side effects, and if they help with heart failure sympt…

This study creates a cooperative registry for 500 adults with congenital heart disease, their caregivers, or family members of deceased patients. Members share their medical journey data to help researchers design better future trials. The goal is to advance care by putting patie…

This study follows 150 fetuses diagnosed with a rare heart condition where the pulmonary valve is blocked or very narrow. Researchers aim to create a tool that predicts whether a baby can have a two-sided heart repair after birth, which leads to better survival and quality of lif…

This study aims to discover hidden heart electrical problems in high-risk pregnancies that might lead to fetal death. Researchers will use a new, non-invasive monitor called fetal magnetocardiography (fMCG) on 30 pregnant women with conditions like congenital heart disease or twi…

This study looks at how a mother's mental health during pregnancy affects the brain development of babies born with serious heart defects. Researchers will follow 174 mothers and their babies from the third trimester until the child's first birthday. The goal is to understand if …

This study looks at better ways to help teenagers with congenital heart disease switch from pediatric to adult healthcare. Researchers will compare education led by nurses versus doctors. About 450 patients, their supporters, and providers will take part to see which approach wor…

This study tests whether using a video laryngoscope helps doctors place a breathing tube through the nose more successfully on the first try compared to a standard direct laryngoscope. It includes 180 infants under 1 year old with congenital heart disease who need surgery. The go…

This study tests a new ultrasound technology called NeoDoppler that can continuously monitor blood flow in the brains of sick and premature infants. Researchers will enroll 180 newborns, including healthy preterm and term babies as well as those with conditions like heart defects…

This study is testing a new 3D ultrasound technique to see if it can accurately measure heart size and pumping ability in children and young adults born with a single ventricle (one pumping chamber). About 100 participants will get a standard heart ultrasound and/or MRI, and the …

This study aims to find the genetic causes of congenital heart disease, the most common birth defect. Researchers will use whole genome sequencing to analyze DNA from up to 5,000 people with the condition and their relatives. No treatment is offered; the goal is to better underst…

This study tests a new, non-invasive mapping system that creates a 3D electrical map of the heart to find abnormal heart rhythm sources in people with congenital heart disease. Researchers will compare this system's accuracy against standard invasive methods in 15 participants. T…

This study looks at oxygen levels in the kidneys of very premature babies (born before 32 weeks) who have a heart condition called patent ductus arteriosus (PDA). Researchers want to see how kidney oxygen relates to the severity of the PDA and whether it can predict kidney injury…

This study aims to find out why people with certain congenital heart conditions, like Tetralogy of Fallot, develop symptoms such as shortness of breath and palpitations, and how their heart structure changes over time. Researchers will use imaging and exercise tests in 300 partic…

This study looks at why newborns with severe congenital heart disease are more likely to develop dangerous blood clots after heart surgery. Researchers will collect blood samples from 10 babies to study tiny molecules called microRNAs that control inflammation and clotting. The g…

This study is a registry that will collect health information from 5,000 adults with congenital heart disease who are treated at specialized Swiss centers. The goal is to learn about long-term complications and what treatments work best. Participants simply allow their medical da…

This study is for children aged 10-18 with certain heart conditions or who have had a heart transplant. Researchers will use special MRI scans taken during exercise to see how the heart and skeletal muscles work together. The goal is to learn more about what affects fitness in th…

This study looks at why some adults who had Fontan surgery for a heart defect develop serious liver scarring. Researchers will use blood tests, imaging, and liver biopsies to track changes over time. The goal is to find early signs of liver disease and understand what causes it. …

This study aims to improve how we detect and understand heart disease using a new type of MRI that looks at the heart's microscopic structure. Researchers will compare these advanced scans with standard tests and blood work in 1,000 adults, both healthy volunteers and those with …

This study looks at how well the heart works during exercise compared to rest in people with congenital heart disease. Researchers will use special catheters to measure blood flow and pressures while participants exercise. The goal is to find hidden heart issues that standard res…

This study looks at 3,000 people with complex congenital heart disease who had or will have heart surgery. Researchers will analyze medical records and follow-up data to find key risk factors for recovery. The goal is to build a national database and quality control system to imp…

This study uses small pieces of heart tissue removed during necessary heart surgery in children with congenital heart disease. Researchers want to learn how calcium helps heart cells control their contraction force and how this differs between infants and adults. They also aim to…

This study looks at whether using a 3D-printed model of a child's heart helps surgeons better plan a procedure to place a mechanical pump (VAD) in children with congenital heart disease and heart failure. About 36 children weighing over 3 kilograms will take part. Researchers wil…

This study tests a computer program that helps doctors decide when to remove a breathing tube from children after heart surgery. About 330 children under 12 who have been on a ventilator for at least 48 hours will take part. The goal is to see if the tool shortens the time they n…

This study looks at whether pulse oximeters—the clips placed on fingers to measure oxygen levels—work equally well for children with different skin tones who have congenital heart disease. Researchers will enroll 92 children under 18 undergoing heart surgery and compare the oxime…